公开(公告)号：US12121879B2

公开(公告)日：2024-10-22

申请号：US17298968

申请日：2019-12-02

Applicant: CytoSorbents Corporation

Inventor： Tamaz Guliashvili ,  Maryann Gruda ,  Thomas Golobish ,  David James ,  Karl-Gustav Ruggeberg ,  Pamela O'Sullivan ,  Sarah Patterson

IPC: B01J20/32 ,  B01D15/38 ,  B01J20/28 ,  C07K1/22 ,  C07K16/06

CPC classification number: B01J20/3274 ,  B01D15/3809 ,  B01J20/28019 ,  B01J20/28078 ,  B01J20/3212 ,  C07K1/22 ,  C07K16/065

Abstract: The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.