公开(公告)号：US20240158372A1

公开(公告)日：2024-05-16

申请号：US18451757

申请日：2023-08-17

申请人： Amgen Inc. ,  Cytokinetics, Inc.

发明人： Luke ASHCRAFT ,  Alessandro BOEZIO ,  John BUTLER ,  Aroop CHANDRA ,  Chihyuan CHUANG ,  Scott E. COLLIBEE ,  Mikkel DEBENEDETTO ,  Vincent DIMASSA ,  Russell GRACEFFA ,  Justin MALINOWSKI ,  David MOEBIUS ,  Bradley P. MORGAN ,  Joshua PAYETTE ,  Antonio ROMERO ,  David ST. JEAN, JR. ,  Richard VARGAS ,  John YEOMAN ,  Hanmo ZHANG ,  Alan CHENG ,  Felix GONZALEZ LOPEZ DE TURISO ,  Michael Garrett JOHNSON

IPC分类号： C07D403/12 ,  A61P9/00 ,  C07D207/16 ,  C07D209/02 ,  C07D209/52 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D403/12 ,  A61P9/00 ,  C07D207/16 ,  C07D209/02 ,  C07D209/52 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

公开(公告)号：US20220332708A1

公开(公告)日：2022-10-20

申请号：US17713946

申请日：2022-04-05

申请人： Cytokinetics, Inc.

发明人： Jeffrey GARDINA ,  Aroop CHANDRA ,  Luke W. ASHCRAFT ,  Scott COLLIBEE ,  Chihyuan CHUANG ,  Alex MUCI - DECEASED ,  Bradley P. MORGAN ,  Antonio ROMERO ,  Michael JOHNSON ,  David MOEBIUS ,  Hanmo ZHANG ,  Felix GONZALEZ

IPC分类号： C07D405/14 ,  C07D403/12 ,  C07D403/14 ,  C07D239/96 ,  C07D401/12 ,  C07D401/14

摘要： The present disclosure relates to sulfonamide compounds and pharmaceutically acceptable salts thereof as cardiac sarcomere activators.

公开(公告)号：US20220281850A1

公开(公告)日：2022-09-08

申请号：US17672594

申请日：2022-02-15

申请人： Amgen Inc. ,  Cytokinetics, Inc.

发明人： Luke ASHCRAFT ,  Alessandro BOEZIO ,  John BUTLER ,  Aroop CHANDRA ,  Chihyuan CHUANG ,  Scott E. COLLIBEE ,  Mikkel DEBENEDETTO ,  Vincent DIMASSA ,  Russell GRACEFFA ,  Justin MALINOWSKI ,  David MOEBIUS ,  Bradley P. MORGAN ,  Joshua PAYETTE ,  Antonio ROMERO ,  David ST. JEAN, JR. ,  Richard VARGAS ,  John YEOMAN ,  Hanmo ZHANG ,  Alan CHENG ,  Felix GONZALEZ LOPEZ DE TURISO ,  Michael Garrett JOHNSON

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  A61P9/00 ,  C07D413/14 ,  C07D207/16 ,  C07D209/52 ,  C07D405/12 ,  C07D417/14 ,  C07D401/06 ,  C07D403/14 ,  C07D209/02 ,  C07D413/12

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.