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公开(公告)号：US20230133132A1
公开(公告)日：2023-05-04
申请号：US17798296
申请日：2021-02-05
申请人： Cytokinetics, Inc.
IPC分类号： C07D295/073 , C07D211/60 , C07D233/64 , C07D231/12 , C07C275/42 , C07C275/40 , C07D487/04 , C07D241/12 , C07D241/38 , C07D207/08 , C07D207/06 , C07D307/16 , C07D309/14 , C07D487/08 , C07D305/08 , C07D335/02 , C07D205/04 , C07D491/107 , C07D333/08 , C07D331/04 , C07D471/08 , C07D487/10 , C07D271/10 , C07D261/08 , C07D401/04 , C07D471/10 , C07D405/04 , C07D209/52 , C07D401/06 , C07D403/06 , C07D243/08 , C07D237/08 , C07D275/02 , C07D305/14 , C07D497/10 , C07D498/10 , C07D263/30 , C07D491/08 , C07D279/12 , C07D249/08
摘要： Provided are compounds of Formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20230348369A1
公开(公告)日：2023-11-02
申请号：US17923167
申请日：2021-05-05
申请人： Cytokinetics, Inc.
发明人： Antonio ROMERO , Aroop CHANDRA , Christopher EVANS , Minxing SHEN
IPC分类号： C07C275/26 , C07D401/12 , C07D211/58 , C07D213/40 , C07D231/12 , C07D261/08 , C07D211/26 , C07D413/12 , C07D213/74 , C07D221/20 , C07D213/38 , C07C275/18 , C07D205/12 , C07D207/06 , C07D205/04 , C07D401/04 , C07D295/16 , C07D215/08 , C07D217/04 , C07D209/44 , C07D209/08 , C07D307/22 , C07D209/54 , C07D265/36 , C07D471/04 , C07D305/08 , C07C311/13 , C07C311/20 , C07D241/04 , C07D215/06 , C07D403/12 , C07D231/56 , C07D401/06 , C07D403/04 , C07D403/10 , C07D213/82 , C07D213/81 , C07C317/32 , C07D213/87 , C07D295/182 , C07D207/08 , C07D241/08 , C07D207/267 , C07D249/06 , C07D335/02 , C07D231/14 , C07D309/08 , C07D211/78 , C07D213/75 , C07D213/56 , C07D405/06 , C07D413/06 , C07D271/10 , C07D263/56 , C07D241/12 , C07D249/08 , C07D239/26 , C07D213/68 , C07D213/65 , C07C317/30 , C07D213/71 , C07D401/14
CPC分类号： C07C275/26 , C07D401/12 , C07D211/58 , C07D213/40 , C07D231/12 , C07D261/08 , C07D211/26 , C07D413/12 , C07D213/74 , C07D221/20 , C07D213/38 , C07C275/18 , C07D205/12 , C07D207/06 , C07D205/04 , C07D401/04 , C07D295/16 , C07D215/08 , C07D217/04 , C07D209/44 , C07D209/08 , C07D307/22 , C07D209/54 , C07D265/36 , C07D471/04 , C07D305/08 , C07C311/13 , C07C311/20 , C07D241/04 , C07D215/06 , C07D403/12 , C07D231/56 , C07D401/06 , C07D403/04 , C07D403/10 , C07D213/82 , C07D213/81 , C07C317/32 , C07D213/87 , C07D295/182 , C07D207/08 , C07D241/08 , C07D207/267 , C07D249/06 , C07D335/02 , C07D231/14 , C07D309/08 , C07D211/78 , C07D213/75 , C07D213/56 , C07D405/06 , C07D413/06 , C07D271/10 , C07D263/56 , C07D241/12 , C07D249/08 , C07D239/26 , C07D213/68 , C07D213/65 , C07C317/30 , C07D213/71 , C07D401/14 , C07C2602/50 , C07C2601/14 , C07C2601/04 , C07C2601/02 , C07C2602/08 , C07C2602/10 , C07B2200/05
摘要： Provided are compounds of Formula (II): or a pharmaceutically acceptable salt thereof, wherein R1, n, and Y1 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240158372A1
公开(公告)日：2024-05-16
申请号：US18451757
申请日：2023-08-17
申请人： Amgen Inc. , Cytokinetics, Inc.
发明人： Luke ASHCRAFT , Alessandro BOEZIO , John BUTLER , Aroop CHANDRA , Chihyuan CHUANG , Scott E. COLLIBEE , Mikkel DEBENEDETTO , Vincent DIMASSA , Russell GRACEFFA , Justin MALINOWSKI , David MOEBIUS , Bradley P. MORGAN , Joshua PAYETTE , Antonio ROMERO , David ST. JEAN, JR. , Richard VARGAS , John YEOMAN , Hanmo ZHANG , Alan CHENG , Felix GONZALEZ LOPEZ DE TURISO , Michael Garrett JOHNSON
IPC分类号： C07D403/12 , A61P9/00 , C07D207/16 , C07D209/02 , C07D209/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/14
CPC分类号： C07D403/12 , A61P9/00 , C07D207/16 , C07D209/02 , C07D209/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US20220332708A1
公开(公告)日：2022-10-20
申请号：US17713946
申请日：2022-04-05
申请人： Cytokinetics, Inc.
发明人： Jeffrey GARDINA , Aroop CHANDRA , Luke W. ASHCRAFT , Scott COLLIBEE , Chihyuan CHUANG , Alex MUCI - DECEASED , Bradley P. MORGAN , Antonio ROMERO , Michael JOHNSON , David MOEBIUS , Hanmo ZHANG , Felix GONZALEZ
IPC分类号： C07D405/14 , C07D403/12 , C07D403/14 , C07D239/96 , C07D401/12 , C07D401/14
摘要： The present disclosure relates to sulfonamide compounds and pharmaceutically acceptable salts thereof as cardiac sarcomere activators.
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公开(公告)号：US20220281850A1
公开(公告)日：2022-09-08
申请号：US17672594
申请日：2022-02-15
申请人： Amgen Inc. , Cytokinetics, Inc.
发明人： Luke ASHCRAFT , Alessandro BOEZIO , John BUTLER , Aroop CHANDRA , Chihyuan CHUANG , Scott E. COLLIBEE , Mikkel DEBENEDETTO , Vincent DIMASSA , Russell GRACEFFA , Justin MALINOWSKI , David MOEBIUS , Bradley P. MORGAN , Joshua PAYETTE , Antonio ROMERO , David ST. JEAN, JR. , Richard VARGAS , John YEOMAN , Hanmo ZHANG , Alan CHENG , Felix GONZALEZ LOPEZ DE TURISO , Michael Garrett JOHNSON
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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