公开(公告)号：US20230233768A1

公开(公告)日：2023-07-27

申请号：US18003643

申请日：2021-06-11

Applicant: DAICEL CORPORATION

Inventor： Yuzo YAMAMOTO ,  Hiromitsu IGA

IPC: A61M5/30 ,  A61M5/20

CPC classification number: A61M5/30 ,  A61M5/2046 ,  A61M2205/3331

Abstract: A needleless injector that ejects an injection substance to a target region without using an injection needle, the needleless injector includes: an injector body formed by a resin member; an igniter; a housing part in which the injection substance is accommodated; and a piston that is configured to be moved by ejection energy in a predetermined path, communicating with the combustion chamber, to pressurize the injection substance. A reinforcing member is provided inside the injector body, formed by a metal member to be a tubular member, and extends in an axial direction of the injector body while surrounding at least the igniter and the combustion chamber, the reinforcing member being disposed to be sandwiched between parts of the injector body in a radial direction of the injector body.

公开(公告)号：US20220072232A1

公开(公告)日：2022-03-10

申请号：US17418552

申请日：2019-12-27

Applicant: DAICEL CORPORATION

Inventor： Takamasa SUZUKI ,  Takashi HASEGAWA ,  Shingo ATOBE ,  Yuzo YAMAMOTO ,  Hiromitsu IGA

IPC: A61M5/30

Abstract: A needleless injector according to the present disclosure includes a housing part including an accommodating space in which an intended injection substance is accommodated. The housing part includes: a housing part main body incorporating the accommodating space; a protrusion including a distal end surface in which an ejection port is formed, the protrusion having an outer diameter that is smaller than an outer diameter of the housing part main body, the distal end surface having an outer circumference edge represented by an intersection point between a first straight line and a second straight line; and a connection part connecting the protrusion and the housing part main body to each other, and having an outer surface forming an annular inclined surface that is inclined with respect to a center axis of the housing part.

公开(公告)号：US20240017011A1

公开(公告)日：2024-01-18

申请号：US18251522

申请日：2021-09-15

Applicant: DAICEL CORPORATION

Inventor： Yasunori IWAI ,  Takamasa SUZUKI ,  Yuzo YAMAMOTO

IPC: A61M5/30

CPC classification number: A61M5/30 ,  A61M2202/0007

Abstract: A device assembly for a needleless injector including a gas generating agent formed such that a combustion rate thereof is lower than a combustion rate of an ignition agent and a combustion duration thereof is longer than a combustion duration of the ignition agent. The device assembly may be configured to pressurize the injection objective substance such that an ejection pressure of the injection objective substance, defined as a pressure of the injection objective substance ejected from an ejection port, increases to a first peak pressure after pressurization is started, decreases to a pressure lower than the first peak pressure, and then increases again to a second peak pressure. The device assembly may be configured to activate an igniter and cause the ejection pressure of the injection objective substance to reach the first peak pressure by a pressure of a combustion gas of the ignition agent.

公开(公告)号：US20220062556A1

公开(公告)日：2022-03-03

申请号：US17423239

申请日：2019-12-27

Applicant: DAICEL CORPORATION

Inventor： Hiromitsu IGA ,  Yuzo YAMAMOTO

IPC: A61M5/30

Abstract: A needleless injector includes a housing part that has an accommodating space that accommodates the intended injection substance, a nozzle portion that defines a flow path for guiding the intended injection substance accommodated in the housing part to the ejection port, a driving part that imparts ejection energy for ejecting the intended injection substance, a pressurizing portion that pressurizes the intended injection substance accommodated in the accommodating space via a propellant disposed to move or deform in a predetermined direction inside the needleless injector by imparting the ejection energy, and a notification unit that, after the ejection energy is imparted by the driving part and the intended injection substance is delivered into the target region, makes a predetermined notification regarding a first timing for canceling a contact state between the ejection port and the surface of the target region to a user.

公开(公告)号：US20220062555A1

公开(公告)日：2022-03-03

申请号：US17418335

申请日：2019-12-27

Applicant: DAICEL CORPORATION

Inventor： Yayoi HIRAYAMA ,  Hiromitsu IGA ,  Yuzo YAMAMOTO

IPC: A61M5/30 ,  A61M5/31 ,  A61M5/315 ,  A61M5/20

Abstract: A needleless injector includes a first switch and a second switch that is provided to an injector enclosure for activation of a driving part. The first switch is arranged to be slidable in a predetermined direction different from a contact direction of a palm of the user, in a first region on a side surface that is a part of a surface of the injector enclosure positioned on side of the user, the first region being covered by the palm of the user in a holding state of the user, and the second switch has an upper side surface with at least a part inclined toward the side of the user to be visible from the user in a holding state of the user, and is arranged on an upper side of the injector enclosure to be able to be pressed.

公开(公告)号：US20220000717A1

公开(公告)日：2022-01-06

申请号：US17282721

申请日：2019-10-03

Applicant: DAICEL CORPORATION

Inventor： Yuzo YAMAMOTO ,  Takamasa SUZUKI

IPC: A61J1/20

Abstract: The adapter includes a housing and a filling nozzle provided in communication with a containing portion in the housing and coming into contact with an end surface of the injection device, in which the injection port of the injection nozzle is formed, when the housing is attached to the injection device. An open end of the filling nozzle is set to be smaller than an inner diameter of the containing portion and larger than the injection port. Of an internal space of the housing from a partial region of the containing portion to the open end, at least a predetermined space being continuous and including the partial region is formed in a manner where an inner diameter of the predetermined space decreases toward a side of the open end. According to this configuration, the injection fluid can be suitably transferred from the outside to a needleless injector.

公开(公告)号：US20180168789A1

公开(公告)日：2018-06-21

申请号：US15737268

申请日：2016-06-15

Applicant: MIE UNIVERSITY ,  DAICEL CORPORATION

Inventor： Hiroshi SHIKU ,  Yuzo YAMAMOTO ,  Takaya MASUMOTO

IPC: A61D1/02 ,  A61K39/00 ,  A61K9/00

CPC classification number: A61D1/025 ,  A61D7/00 ,  A61K9/0019 ,  A61K31/7088 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/552 ,  A61M5/2046 ,  A61M5/30

Abstract: A needleless injector which can selectively induce the immune response and a method for introducing DNA including a region coding for an antigen to selectively produce an antibody in a living body of a mammal by using the needleless injector are provided. Disclosed is a needleless injector for injecting a DNA solution into an injection target area without using any injection needle. The needleless injector includes an accommodating unit which accommodates the DNA solution, a predetermined ignition device and a predetermined nozzle unit. A temperature of the predetermined combustion product, which is provided during the pressurization, changes to a neighborhood of ordinary temperature within 20 msec after a pressure, which is applied to the DNA solution on account of the combustion of the igniter powder, reaches an initial peak discharge force during a pressurization process for discharging the DNA solution.

公开(公告)号：US20180036486A1

公开(公告)日：2018-02-08

申请号：US15728354

申请日：2017-10-09

Applicant: DAICEL CORPORATION

Inventor： Yuzo YAMAMOTO

IPC: A61M5/315

CPC classification number: A61M5/315 ,  A61J1/2096 ,  A61M5/30 ,  A61M5/31515 ,  A61M2205/8231

Abstract: A syringe has a syringe main body, a syringe unit, and a piston. An end surface of the piston disposed on a forward end side is brought in contact with an end surface of a plunger disposed on a proximal end side so that the plunger is slidable toward a discharge port in a state in which a rod portion is accommodated in an accommodating hole in an attached state. In the attached state, the syringe unit is attached to the syringe main body, and a position of the plunger in a charging chamber is determined at a predetermined position at which an amount of an injection objective substance in the charging chamber is a predetermined amount on the basis of a position of the piston arranged in a through-hole of the syringe main body. Accordingly, the syringe is easily handled and the injection objective substance can be correctly charged.

公开(公告)号：US20220072231A1

公开(公告)日：2022-03-10

申请号：US17415956

申请日：2019-12-27

Applicant: DAICEL CORPORATION

Inventor： Yuzo YAMAMOTO ,  Hiromitsu IGA

IPC: A61M5/30 ,  A61M5/315 ,  A61M5/20

Abstract: A needleless injector includes a housing part that includes an accommodating space and defines a flow path for ejection, a driving part that imparts ejection energy, and a plunger that defines the accommodating space and is disposed to move in the housing part by the ejection energy and pressurize a substance intended for injection. The plunger includes a weakened part that causes a part of the plunger to deform such that, when force applied to the plunger exceeds predefined force while the driving part is imparting the ejection energy with the accommodating space accommodating the substance intended for injection, a distal end of the plunger does not reach an inner wall surface at a deepest part of the housing part or force received by the inner wall surface falls within a predetermined range until the distal end of the plunger reaches the inner wall surface.

公开(公告)号：US20210162131A1

公开(公告)日：2021-06-03

申请号：US17263310

申请日：2019-08-02

Applicant: DAICEL CORPORATION

Inventor： Takamasa SUZUKI ,  Yuzo YAMAMOTO ,  Yuko SAKAGUCHI

IPC: A61M5/30 ,  A61M5/315

Abstract: A needleless injector configured to inject an injection intended substance to an injection target region, by injecting the injection intended substance includes a nozzle portion and a pressing portion, and a predetermined gap is formed between the nozzle portion and the pressing portion. The nozzle portion is formed to have a portion of the distal end portion that comes into contact with the injection target region and has a width (a) falling within a range from 3.5 mm to 5.5 mm, and a ratio (b/a) defined by an inner diameter (b) of a portion of a distal end portion of the pressing portion that comes into contact with the injection target region by the width (a) falls within a range from 1.5 to 5.0. A part of the injection target region is received in the predetermined gap when the pressing portion presses the injection target region.