公开(公告)号：US20200276392A1

公开(公告)日：2020-09-03

申请号：US16626291

申请日：2018-06-27

Applicant: DAICEL CORPORATION

Inventor： Takamasa SUZUKI ,  Shingo ATOBE ,  Hiroshi MIYAZAKI ,  Hiromitsu IGA ,  Katsuya MIKI

IPC: A61M5/20 ,  A61M5/30

Abstract: A needleless injector pressurizes a substance to be injected having an ejection pressure defined as a pressure of the substance to be injected ejected through an ejection port. The ejection pressure is raised to a first peak pressure after pressurizing is started, is lowered to a pressure lower than the first peak pressure afterward, and then is raised to a second peak pressure again. An on-completion reached depth that is an on-completion reached depth of the substance when the pressurizing portion completes pressurizing is adjustable, the on-completion reached depth being increased along with increase of the first peak pressure and being increased along with reduction of a length between peaks from a first timing at which the ejection pressure reaches the first peak pressure to a second timing at which the ejection pressure reaches the second peak pressure.

公开(公告)号：US20220072232A1

公开(公告)日：2022-03-10

申请号：US17418552

申请日：2019-12-27

Applicant: DAICEL CORPORATION

Inventor： Takamasa SUZUKI ,  Takashi HASEGAWA ,  Shingo ATOBE ,  Yuzo YAMAMOTO ,  Hiromitsu IGA

IPC: A61M5/30

Abstract: A needleless injector according to the present disclosure includes a housing part including an accommodating space in which an intended injection substance is accommodated. The housing part includes: a housing part main body incorporating the accommodating space; a protrusion including a distal end surface in which an ejection port is formed, the protrusion having an outer diameter that is smaller than an outer diameter of the housing part main body, the distal end surface having an outer circumference edge represented by an intersection point between a first straight line and a second straight line; and a connection part connecting the protrusion and the housing part main body to each other, and having an outer surface forming an annular inclined surface that is inclined with respect to a center axis of the housing part.

公开(公告)号：US20240390590A1

公开(公告)日：2024-11-28

申请号：US18796095

申请日：2024-08-06

Applicant: DAICEL CORPORATION

Inventor： Katsuya MIKI ,  Shingo ATOBE ,  Hiroshi MIYAZAKI ,  Ayano SUZUKI ,  Yuko SAKAGUCHI

IPC: A61M5/30 ,  A61M5/20 ,  A61M11/00 ,  A61M11/02 ,  A61M11/06

Abstract: Proposed is an injector in which when a solution containing biomolecules is injected into an injection target, a proportion of biomolecules that function in the injection target with respect to the injected biomolecules is large. This application also relates to a method of injecting a solution containing biomolecules into an injection target using the injector. In one aspect, the injector injects the solution containing biomolecules into the injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target. The injector may include an accommodation unit and a nozzle unit, wherein the injector satisfies a given condition.

公开(公告)号：US20210023302A1

公开(公告)日：2021-01-28

申请号：US16968095

申请日：2019-02-08

Applicant: DAICEL CORPORATION

Inventor： Katsuya MIKI ,  Shingo ATOBE ,  Hiroshi MIYAZAKI ,  Ayano SUZUKI ,  Yuko SAKAGUCHI

IPC: A61M5/20

Abstract: This application relates to an injector that can directly inject a solution containing biomolecules into a cell nucleus of a wide range of injection targets with high efficiency. In one aspect, the injector injects a solution containing biomolecules into an injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target. The injector may include an accommodation unit and a nozzle unit, wherein the injector satisfies given conditions.

公开(公告)号：US20210038818A1

公开(公告)日：2021-02-11

申请号：US16968134

申请日：2019-02-08

Applicant: DAICEL CORPORATION

Inventor： Katsuya MIKI ,  Shingo ATOBE ,  Hiroshi MIYAZAKI ,  Ayano SUZUKI ,  Yuko SAKAGUCHI

IPC: A61M5/30

Abstract: This application relates to an injector and a method that can directly inject a solution containing biomolecules into a cell nucleus of an injection target with high efficiency. In one aspect, the injector injects the solution containing biomolecules into the injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target. The injector may include an accommodation unit for accommodating the solution containing biomolecules and a nozzle unit including an injection port through which the solution containing biomolecules flows and is injected into the injection target, the solution being pressurized. There may be a time at which an injection speed of the solution containing biomolecules is 40 m/s or more between an injection start time of the solution containing biomolecules and a time of 0.20 ms.

公开(公告)号：US20210023314A1

公开(公告)日：2021-01-28

申请号：US16968078

申请日：2019-02-08

Applicant: DAICEL CORPORATION

Inventor： Katsuya MIKI ,  Shingo ATOBE ,  Hiroshi MIYAZAKI ,  Ayano SUZUKI ,  Yuko SAKAGUCHI

IPC: A61M11/02 ,  A61M11/00 ,  A61M11/06

Abstract: This application relates to an injector in which when a solution containing biomolecules is injected into an injection target, a proportion of biomolecules that function in the injection target with respect to the injected biomolecules is large. This application also relates to a method of injecting a solution containing biomolecules into an injection target using the injector. In one aspect, the injector injects the solution containing biomolecules into the injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target. The injector may include an accommodation unit and a nozzle unit, wherein the injector satisfies a given condition.