公开(公告)号：US20230084707A1

公开(公告)日：2023-03-16

申请号：US17714032

申请日：2022-04-05

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Narihiro TODA ,  Yusuke OTA ,  Fuminao DOI ,  Masaki MEGURO ,  Ichiro HAYAKAWA ,  Shinji ASHIDA ,  Takeshi MASUDA ,  Takashi NAKADA ,  Mitsuhiro IWAMOTO ,  Naoya HARADA ,  Tomoko TERAUCHI ,  Daisuke OKAJIMA ,  Kensuke NAKAMURA ,  Hiroaki UCHIDA ,  Hirofumi HAMADA

IPC分类号： A61K47/68 ,  A61P35/00 ,  C07K16/30 ,  C07D487/04

摘要： The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.

公开(公告)号：US20220125943A1

公开(公告)日：2022-04-28

申请号：US17543697

申请日：2021-12-06

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Narihiro TODA ,  Yusuke OTA ,  Fuminao DOI ,  Masaki MEGURO ,  Ichiro HAYAKAWA ,  Shinji ASHIDA ,  Takeshi MASUDA ,  Takashi NAKADA ,  Mitsuhiro IWAMOTO ,  Naoya HARADA ,  Tomoko TERAUCHI ,  Daisuke OKAJIMA ,  Kensuke NAKAMURA ,  Hiroaki UCHIDA ,  Hirofumi HAMADA

IPC分类号： A61K47/68 ,  A61P35/00 ,  C07D487/04 ,  C07K16/30

摘要： The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.

公开(公告)号：US20190225686A1

公开(公告)日：2019-07-25

申请号：US16330085

申请日：2018-01-16

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Kenji IIDA ,  Takehiro HIRAI ,  Tomoko TERAUCHI ,  Kensuke NAKAMURA

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61K31/4745 ,  A61K47/64 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

摘要： It is an object of the present invention to provide an antibody specifically binding to GPR20-positive tumor cells such as GIST, a pharmaceutical product comprising the antibody and having therapeutic effects on a tumor, a method for treating a tumor using the aforementioned pharmaceutical product, and the like. It is another object of the present invention to provide an anti-GPR20 antibody having internalization activity, an antibody-drug conjugate containing the antibody, and the like.

公开(公告)号：US20220395579A1

公开(公告)日：2022-12-15

申请号：US17849688

申请日：2022-06-26

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Narihiro TODA ,  Yusuke OTA ,  Fuminao DOI ,  Masaki MEGURO ,  Ichiro HAYAKAWA ,  Shinji ASHIDA ,  Takeshi MASUDA ,  Takashi NAKADA ,  Mitsuhiro IWAMOTO ,  Naoya HARADA ,  Tomoko TERAUCHI ,  Daisuke OKAJIMA ,  Kensuke NAKAMURA ,  Hiroaki UCHIDA ,  Hirofumi HAMADA

IPC分类号： A61K47/68 ,  A61P35/00 ,  C07D487/04 ,  C07K16/30

摘要： The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.

公开(公告)号：US20200261594A1

公开(公告)日：2020-08-20

申请号：US16651501

申请日：2018-09-28

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Narihiro TODA ,  Yusuke OTA ,  Fuminao DOI ,  Masaki MEGURO ,  Ichiro HAYAKAWA ,  Shinji ASHIDA ,  Takeshi MASUDA ,  Takashi NAKADA ,  Mitsuhiro IWAMOTO ,  Naoya HARADA ,  Tomoko TERAUCHI ,  Daisuke OKAJIMA ,  Kensuke NAKAMURA ,  Hiroaki UCHIDA ,  Hirofumi HAMADA

IPC分类号： A61K47/68 ,  C07D487/04 ,  C07K16/30 ,  A61P35/00

摘要： The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.