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公开(公告)号：US20230084707A1
公开(公告)日：2023-03-16
申请号：US17714032
申请日：2022-04-05
发明人： Narihiro TODA , Yusuke OTA , Fuminao DOI , Masaki MEGURO , Ichiro HAYAKAWA , Shinji ASHIDA , Takeshi MASUDA , Takashi NAKADA , Mitsuhiro IWAMOTO , Naoya HARADA , Tomoko TERAUCHI , Daisuke OKAJIMA , Kensuke NAKAMURA , Hiroaki UCHIDA , Hirofumi HAMADA
IPC分类号： A61K47/68 , A61P35/00 , C07K16/30 , C07D487/04
摘要： The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.
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公开(公告)号：US20220125943A1
公开(公告)日：2022-04-28
申请号：US17543697
申请日：2021-12-06
发明人： Narihiro TODA , Yusuke OTA , Fuminao DOI , Masaki MEGURO , Ichiro HAYAKAWA , Shinji ASHIDA , Takeshi MASUDA , Takashi NAKADA , Mitsuhiro IWAMOTO , Naoya HARADA , Tomoko TERAUCHI , Daisuke OKAJIMA , Kensuke NAKAMURA , Hiroaki UCHIDA , Hirofumi HAMADA
IPC分类号： A61K47/68 , A61P35/00 , C07D487/04 , C07K16/30
摘要： The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.
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公开(公告)号：US20160297890A1
公开(公告)日：2016-10-13
申请号：US15187179
申请日：2016-06-20
发明人： Toshinori AGATSUMA , Shu TAKAHASHI , Jun HASEGAWA , Daisuke OKAJIMA , Hirofumi HAMADA , Miki YAMAGUCHI
IPC分类号： C07K16/30 , A61K31/4745 , A61K47/48
CPC分类号： C07K16/30 , A61K31/4745 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6865 , A61K47/6869 , A61K47/6889 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/24 , C07K2317/77 , C07K2317/92
摘要： It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(═O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(═O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.
摘要翻译： 旨在提供具有优异治疗效果的抗肿瘤药物，其在抗肿瘤效果和安全性方面是优异的。 提供了一种抗体 - 药物偶联物，其中由下式表示的抗肿瘤化合物通过具有由下式表示的结构的接头与抗TROP2抗体缀合：-L1-L2-LP-NH-（CH2） n1-La-（CH2）n2-C（= O） - 其中抗TROP2抗体连接到L1的末端，并且抗肿瘤化合物连接到 - （CH 2）n 2 -C（= O） - 部分与位置1处的氨基的氮原子作为连接位置。
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公开(公告)号：US20220395579A1
公开(公告)日：2022-12-15
申请号：US17849688
申请日：2022-06-26
发明人： Narihiro TODA , Yusuke OTA , Fuminao DOI , Masaki MEGURO , Ichiro HAYAKAWA , Shinji ASHIDA , Takeshi MASUDA , Takashi NAKADA , Mitsuhiro IWAMOTO , Naoya HARADA , Tomoko TERAUCHI , Daisuke OKAJIMA , Kensuke NAKAMURA , Hiroaki UCHIDA , Hirofumi HAMADA
IPC分类号： A61K47/68 , A61P35/00 , C07D487/04 , C07K16/30
摘要： The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.
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公开(公告)号：US20210238303A1
公开(公告)日：2021-08-05
申请号：US17230543
申请日：2021-04-14
发明人： Toshinori AGATSUMA , Shu TAKAHASHI , Jun HASEGAWA , Daisuke OKAJIMA , Hirofumi HAMADA , Miki YAMAGUCHI
IPC分类号： C07K16/30 , A61K31/4745 , A61K47/68
摘要： It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(═O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(═O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.
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公开(公告)号：US20200261594A1
公开(公告)日：2020-08-20
申请号：US16651501
申请日：2018-09-28
发明人： Narihiro TODA , Yusuke OTA , Fuminao DOI , Masaki MEGURO , Ichiro HAYAKAWA , Shinji ASHIDA , Takeshi MASUDA , Takashi NAKADA , Mitsuhiro IWAMOTO , Naoya HARADA , Tomoko TERAUCHI , Daisuke OKAJIMA , Kensuke NAKAMURA , Hiroaki UCHIDA , Hirofumi HAMADA
IPC分类号： A61K47/68 , C07D487/04 , C07K16/30 , A61P35/00
摘要： The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.
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公开(公告)号：US20180094073A1
公开(公告)日：2018-04-05
申请号：US15821662
申请日：2017-11-22
发明人： Toshinori AGATSUMA , Shu TAKAHASHI , Jun HASEGAWA , Daisuke OKAJIMA , Hirofumi HAMADA , Miki YAMAGUCHI
IPC分类号： C07K16/30 , A61K31/4745
CPC分类号： C07K16/30 , A61K31/4745 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6865 , A61K47/6869 , A61K47/6889 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/24 , C07K2317/77 , C07K2317/92
摘要： It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(═O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(═O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.
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