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7 条记录 (耗时 0.031 秒)

    ANTI-CDH6 ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE
    1.
    发明申请
    ANTI-CDH6 ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE 有权

    公开(公告)号：US20220016257A1

    公开(公告)日：2022-01-20

    申请号：US17293577

    申请日：2019-11-13

    申请人： DAIICHI SANKYO COMPANY, LIMITED

    发明人： Atsuko SAITO ,  Naoya HARADA ,  Kozo YONEDA ,  Ichiro HAYAKAWA ,  Masaki MEGURO ,  Fuminao DOI

    IPC分类号： A61K47/68 ,  C07K16/28 ,  A61K47/54 ,  A61K47/65 ,  A61P35/00

    摘要： An object of the present invention is to provide an antibody specifically binding to CDH6 and having a high internalization activity, an antibody-drug conjugate comprising the antibody and a high antitumor activity, a pharmaceutical product having the antibody-drug conjugate and having a therapeutic effect on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like.
    According to the present invention, it is possible to provide an anti-CDH6 antibody prepared having internalization activity, an anti-CDH6 antibody-drug conjugate prepared by connecting the anti-CDH6 antibody and a novel PBD derivative and exhibiting high anti-tumor activity, a pharmaceutical product and a therapeutic method for treating tumors using these.

    Phenylxanthene Derivatives
    7.
    发明申请
    Phenylxanthene Derivatives 有权
    苯基呫吨衍生物

    公开(公告)号：US20140343052A1

    公开(公告)日：2014-11-20

    申请号：US14291860

    申请日：2014-05-30

    申请人： Daiichi Sankyo Company, Limited

    发明人： Shigeo YAMANOI ,  Katsuji KAGECHIKA ,  Tsuyoshi SONEDA ,  Yuichi OCHIAI ,  Hidenori NAMIKI ,  Fuminao DOI ,  Madoka HOSHINO ,  Shoko YOSHIDA

    IPC分类号： C07D405/10 ,  C07D413/14 ,  C07D405/14

    CPC分类号： C07D405/10 ,  C07D405/14 ,  C07D413/14

    摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent glucose lowering effect.A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein R1 represents a C1-C3 alkyl group, each substituent R2 may be the same or different and may each represent a C1-C3 alkyl group, R3 represents an optionally substituted pyridyl group or the like, R4 and R5, which are the same or different, each represent a C1-C3 alkyl group, R6 and R7, which are the same or different, each represent a C1-C3 alkyl group, and n represents 0 to 3.

    摘要翻译： 本发明涉及具有优异葡萄糖降低作用的化合物或其药理学上可接受的盐。 由以下通式（I）表示的化合物或其药学上可接受的盐：其中R1表示C1-C3烷基，各取代基R2可以相同或不同，可各自表示C1-C3烷基，R3表示 任选取代的吡啶基等，R 4和R 5相同或不同，各自表示C1-C3烷基，R6和R7相同或不同，分别表示C1-C3烷基，和 n表示0〜3。