公开(公告)号：US12091395B2

公开(公告)日：2024-09-17

申请号：US18501481

申请日：2023-11-03

申请人： Daiichi Sankyo Company, Limited

发明人： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC分类号： C07D307/94 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/4245 ,  C07D405/04 ,  C07D405/10 ,  C07D407/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14

CPC分类号： C07D307/94 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/4245 ,  C07D405/04 ,  C07D405/10 ,  C07D407/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14

摘要： An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof.




wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US11834427B2

公开(公告)日：2023-12-05

申请号：US18046270

申请日：2022-10-13

申请人： Daiichi Sankyo Company, Limited

发明人： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC分类号： C07D307/94 ,  C07D405/04 ,  C07D405/10 ,  C07D407/12 ,  C07D413/04 ,  C07D413/14 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/4245 ,  C07D413/10

CPC分类号： C07D307/94 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/4245 ,  C07D405/04 ,  C07D405/10 ,  C07D407/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14

摘要： An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof.




wherein the symbols in the formula are defined below:

R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group;

A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US11407746B2

公开(公告)日：2022-08-09

申请号：US16648570

申请日：2018-09-28

申请人： Daiichi Sankyo Company, Limited

发明人： Keiji Saito ,  Katsuyoshi Nakajima ,  Yasuyuki Ogawa ,  Mitsuhiro Makino ,  Kaori Ito ,  Seiko Nagata ,  Makoto Hirasawa

IPC分类号： C07D413/14 ,  C07D307/94 ,  C07D405/10 ,  C07D413/10 ,  C07D309/12 ,  C07D407/12 ,  C07D405/14 ,  C07D498/10

摘要： The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R1: a C1-C6 alkyl group or the like, R2: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R3, R3′: a C1-C6 alkyl group or the like.

公开(公告)号：US20200347030A1

公开(公告)日：2020-11-05

申请号：US16646130

申请日：2018-09-13

申请人： Daiichi Sankyo Company, Limited

发明人： Toru Taniguchi ,  Osamu Iwamoto ,  Keiji Saito ,  Katsuyoshi Nakajima ,  Yasuyuki Ogawa ,  Nobuya Kurikawa ,  Seiko Nagata ,  Kaori Ito ,  Eriko Kioi

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D471/04 ,  C07D405/14 ,  C07D413/14 ,  C07D498/10

摘要： An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: A: e.g., Benzene, E: e.g., —CH2—, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R1, R2, R3: e.g., a halogen atom, R4: e.g., a C1-C6 alkyl group, R5: e.g., a hydrogen atom, R6a, R6b, R6c, R6d: e.g., a hydrogen atom, R7: e.g., a hydrogen atom, R8: e.g., a hydrogen atom, n1, n2, n3: e.g., 1.

公开(公告)号：US20190092741A1

公开(公告)日：2019-03-28

申请号：US16088696

申请日：2017-03-29

申请人： Daiichi Sankyo Company, Limited

发明人： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC分类号： C07D307/94 ,  C07D413/14 ,  C07D413/10 ,  C07D405/10 ,  C07D407/12

摘要： An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US11993593B2

公开(公告)日：2024-05-28

申请号：US17845426

申请日：2022-06-21

申请人： Daiichi Sankyo Company, Limited

发明人： Keiji Saito ,  Katsuyoshi Nakajima ,  Yasuyuki Ogawa ,  Mitsuhiro Makino ,  Kaori Ito ,  Seiko Nagata ,  Makoto Hirasawa

IPC分类号： C07D413/14 ,  C07D307/94 ,  C07D309/12 ,  C07D405/10 ,  C07D405/14 ,  C07D407/12 ,  C07D413/10 ,  C07D498/10

CPC分类号： C07D413/14 ,  C07D307/94 ,  C07D309/12 ,  C07D405/10 ,  C07D405/14 ,  C07D407/12 ,  C07D413/10 ,  C07D498/10

摘要： The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R1: a C1-C6 alkyl group or the like, R2: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R3, R3′: a C1-C6 alkyl group or the like].

公开(公告)号：US11512067B2

公开(公告)日：2022-11-29

申请号：US16646130

申请日：2018-09-13

申请人： Daiichi Sankyo Company, Limited

发明人： Toru Taniguchi ,  Osamu Iwamoto ,  Keiji Saito ,  Katsuyoshi Nakajima ,  Yasuyuki Ogawa ,  Nobuya Kurikawa ,  Seiko Nagata ,  Kaori Ito ,  Eriko Kioi

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D498/10

摘要： An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: A: e.g., Benzene, E: e.g., —CH2—, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R1, R2, R3: e.g., a halogen atom, R4: e.g., a C1-C6 alkyl group, R5: e.g., a hydrogen atom, R6a, R6b, R6c, R6d: e.g., a hydrogen atom, R7: e.g., a hydrogen atom, R8: e.g., a hydrogen atom, n1, n2, n3: e.g., 1.

公开(公告)号：US20210292292A1

公开(公告)日：2021-09-23

申请号：US17212373

申请日：2021-03-25

申请人： Daiichi Sankyo Company, Limited

发明人： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC分类号： C07D307/94 ,  C07D405/04 ,  C07D413/04 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/343 ,  C07D405/10 ,  C07D407/12 ,  C07D413/10 ,  C07D413/14

摘要： An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US10975052B2

公开(公告)日：2021-04-13

申请号：US16844621

申请日：2020-04-09

申请人： Daiichi Sankyo Company, Limited

发明人： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC分类号： C07D307/94 ,  C07D405/04 ,  C07D405/10 ,  C07D407/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/4245

摘要： An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US09617232B2

公开(公告)日：2017-04-11

申请号：US14784187

申请日：2014-04-23

申请人： Daiichi Sankyo Company, Limited

发明人： Yoshikazu Uto ,  Mikio Kato ,  Hidenori Takahashi ,  Yasuyuki Ogawa ,  Osamu Iwamoto ,  Hiroko Kono ,  Kazumasa Aoki

IPC分类号： A61K31/196 ,  C07D213/75 ,  A61P3/00 ,  A61K31/40 ,  A61K31/4545 ,  C07D213/82 ,  C07D295/14 ,  A61K31/451 ,  A61P7/00 ,  C07C311/20 ,  C07D295/155

CPC分类号： C07D295/155 ,  C07C311/20 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/16 ,  C07D213/75 ,  C07D213/82 ,  C07D295/14

摘要： It is an object of the present invention to provide a medicament for preventing or treating hyperphosphatemia. Solution: A compound represented by a general formula (I) or a pharmacologically acceptable salt thereof. [In the formula, R1: a methyl group or the like, R2: a hydrogen atom or the like, R3: a hydrogen atom or the like, A: a cyclohexyl ring or the like, X: CH or the like, Y: CH or the like, Z: CH or the like, and n: 2 or the like].