公开(公告)号：US20110183930A1

公开(公告)日：2011-07-28

申请号：US13052633

申请日：2011-03-21

申请人： DANIEL AURIOL ,  Renaud Nalin ,  Patrick Robe ,  Fabrice Lefevre

发明人： DANIEL AURIOL ,  Renaud Nalin ,  Patrick Robe ,  Fabrice Lefevre

IPC分类号： A61K31/7048 ,  C12P19/60 ,  C07H17/07 ,  A61P35/00 ,  A61P9/00 ,  A61P31/04 ,  A61P37/08 ,  C12P19/44 ,  C07H15/203 ,  A61K31/7034

CPC分类号： C07H17/075 ,  C07H15/203 ,  C07H15/24 ,  C07H15/26 ,  C12P17/02 ,  C12P19/02 ,  C12P19/44 ,  C12P19/60

摘要： The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-α-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic, antimutagenic, antineoplastic, anti-thrombotic and vasodilatory formulations, or in any other field of application.

摘要翻译： 本发明涉及通过将选自邻苯二酚或其衍生物的酚类与蔗糖的葡萄糖部分的酶缩合制备酚衍生物。 所述酚衍生物的生产通过葡糖基转移酶（EC 2.4.1.5）来实现。 所选择的酚类的这些O-α-葡萄糖苷是新的，在水中的溶解度高于其亲本多酚的溶解度，并且在化妆品和药物组合物中有用，例如抗氧化，抗病毒，抗菌，免疫刺激，抗过敏，抗高血压， 抗血栓形成，抗血栓形成，抗血栓形成，抗血栓形成，血栓形成和抗血栓形成，抗血栓形成，抗血栓形成，抗血栓形成，抗胆固醇血症，抗脂质过氧化物，肝保护，抗炎，抗致癌，​​抗诱变，抗肿瘤，抗血栓形成和血管扩张制剂。