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    Method for the identification of a metabolic pathway family by means of positive selection
    1.
    发明申请
    Method for the identification of a metabolic pathway family by means of positive selection 有权
    通过阳性选择鉴定代谢途径家族的方法

    公开(公告)号：US20070184449A1

    公开(公告)日：2007-08-09

    申请号：US10591087

    申请日：2005-03-22

    申请人： Pierre Monsan ,  Claude Bensoussan ,  Philippe Reulet ,  Renaud Nalin ,  Patrick Robe ,  Karine Tuphile ,  Benjamin Gillet ,  Pierre Pujic

    发明人： Pierre Monsan ,  Claude Bensoussan ,  Philippe Reulet ,  Renaud Nalin ,  Patrick Robe ,  Karine Tuphile ,  Benjamin Gillet ,  Pierre Pujic

    IPC分类号： C40B40/02 ,  C40B40/08 ,  C40B50/06

    CPC分类号： C12P7/40 ,  C12N2503/02 ,  C12P7/02 ,  C12P13/02 ,  C12P33/00

    摘要： The invention relates to the direct selection of metabolic pathways having a determined function in the transformation of a substrate {Ai} into a target product {B}, which is of interest in the industrial, pharmaceutical or agri-food sectors. More specifically, the invention relates to the detection, within metagenomic libraries, of novel biosynthesis pathways involved in a biochemical reaction having a known product {B}. The selection and characterisation of said novel metabolic pathways enables {B} to be produced enzymatically. The invention provides an alternative to the chemical synthesis of the molecule in question {B}. Moreover, and above all, the invention can be used specifically to target and exploit the only metabolic pathways enabling the transformation of {Ai} into {B}, while eliminating the associated metabolic pathways that can catabolise the target product {B}.

    摘要翻译： 本发明涉及在将底物{Ai}转化为目标产物{B}中具有确定功能的代谢途径的直接选择，其在工业，制药或农业食品领域是感兴趣的。 更具体地，本发明涉及在宏基因组文库中检测参与具有已知产物{B}的生化反应的新生物合成途径。 所述新型代谢途径的选择和表征使得{B}可以酶促产生。 本发明提供了所述分子的化学合成（B）的替代方案。 此外，最重要的是，本发明可以专门用于靶向和利用唯一能够将{Ai}转化为{B}的代谢途径，同时消除可能分解目标产物{B}的相关代谢途径。

    WATER SOLUBLE AND ACTIVABLE PHENOLICS DERIVATIVES WITH DERMOCOSMETIC AND THERAPEUTIC APPLICATIONS AND PROCESS FOR PREPARING SAID DERIVATIVES
    2.
    发明申请
    WATER SOLUBLE AND ACTIVABLE PHENOLICS DERIVATIVES WITH DERMOCOSMETIC AND THERAPEUTIC APPLICATIONS AND PROCESS FOR PREPARING SAID DERIVATIVES 审中-公开
    具有灭菌和治疗应用的水溶性和活性酚醛衍生物和制备上述衍生物的方法

    公开(公告)号：US20110183930A1

    公开(公告)日：2011-07-28

    申请号：US13052633

    申请日：2011-03-21

    申请人： DANIEL AURIOL ,  Renaud Nalin ,  Patrick Robe ,  Fabrice Lefevre

    发明人： DANIEL AURIOL ,  Renaud Nalin ,  Patrick Robe ,  Fabrice Lefevre

    IPC分类号： A61K31/7048 ,  C12P19/60 ,  C07H17/07 ,  A61P35/00 ,  A61P9/00 ,  A61P31/04 ,  A61P37/08 ,  C12P19/44 ,  C07H15/203 ,  A61K31/7034

    CPC分类号： C07H17/075 ,  C07H15/203 ,  C07H15/24 ,  C07H15/26 ,  C12P17/02 ,  C12P19/02 ,  C12P19/44 ,  C12P19/60

    摘要： The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-α-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic, antimutagenic, antineoplastic, anti-thrombotic and vasodilatory formulations, or in any other field of application.

    摘要翻译： 本发明涉及通过将选自邻苯二酚或其衍生物的酚类与蔗糖的葡萄糖部分的酶缩合制备酚衍生物。 所述酚衍生物的生产通过葡糖基转移酶（EC 2.4.1.5）来实现。 所选择的酚类的这些O-α-葡萄糖苷是新的，在水中的溶解度高于其亲本多酚的溶解度，并且在化妆品和药物组合物中有用，例如抗氧化，抗病毒，抗菌，免疫刺激，抗过敏，抗高血压， 抗血栓形成，抗血栓形成，抗血栓形成，抗血栓形成，血栓形成和抗血栓形成，抗血栓形成，抗血栓形成，抗血栓形成，抗胆固醇血症，抗脂质过氧化物，肝保护，抗炎，抗致癌，​​抗诱变，抗肿瘤，抗血栓形成和血管扩张制剂。

    Method for extracting DNA from organisms
    3.
    发明申请
    Method for extracting DNA from organisms 审中-公开
    从生物体中提取DNA的方法

    公开(公告)号：US20060188967A1

    公开(公告)日：2006-08-24

    申请号：US11338364

    申请日：2006-01-24

    申请人： Renaud Nalin ,  Patrick Robe ,  Van Van

    发明人： Renaud Nalin ,  Patrick Robe ,  Van Van

    IPC分类号： C12P19/34

    CPC分类号： G01N27/44773 ,  C12N15/1003

    摘要： A method for the indirect extraction of DNA greater than 300 kb in size from non-cultivatable organisms contained in an environmental sample is disclosed. The method comprises isolating the organisms from the sample and embedding the isolated organisms in a block of agarose where the organisms are subsequently lysed and the DNA subjected to a first alternating field electrophoresis to extract DNA fragments which are large in size and separate them from the cell debris. The first electrophoretic migration is followed by an enzymatic restriction step and additional electrophoretic migrations. The invention also encompasses DNA obtained by the method.

    摘要翻译： 公开了一种从环境样品中所含的不可培养生物体间接提取尺寸大于300kb的DNA的方法。 该方法包括从样品中分离生物体并将分离的生物体包埋在琼脂糖块中，随后将生物体裂解，DNA进行第一次交替场电泳以提取尺寸较大的DNA片段并将其与细胞分离 碎片 第一次电泳迁移之后是酶限制步骤和额外的电泳迁移。 本发明还包括通过该方法获得的DNA。

    Method for the Identification of a Metabolic Pathway Family by Means of Positive Selection
    4.
    发明申请
    Method for the Identification of a Metabolic Pathway Family by Means of Positive Selection 审中-公开
    通过正选择鉴定代谢途径家族的方法

    公开(公告)号：US20100323390A1

    公开(公告)日：2010-12-23

    申请号：US12872280

    申请日：2010-08-31

    申请人： Pierre Monsan ,  Claude Bensoussan ,  Philippe Reulet ,  Renaud Nalin ,  Patrick Robe ,  Karine Tuphile ,  Benjamin Gillet ,  Pierre Pujic

    发明人： Pierre Monsan ,  Claude Bensoussan ,  Philippe Reulet ,  Renaud Nalin ,  Patrick Robe ,  Karine Tuphile ,  Benjamin Gillet ,  Pierre Pujic

    IPC分类号： C12Q1/02 ,  C40B30/06 ,  C12P33/02 ,  C12P7/22 ,  C12P7/42 ,  C12P13/02

    CPC分类号： C12P7/40 ,  C12N2503/02 ,  C12P7/02 ,  C12P13/02 ,  C12P33/00

    摘要： The invention relates to the direct selection of metabolic pathways having a determined function in the transformation of a substrate {Ai} into a target product {B}, which is of interest in the industrial, pharmaceutical or agri-food sectors. More specifically, the invention relates to the detection, within metagenomic libraries, of novel biosynthesis pathways involved in a biochemical reaction having a known product {B}. The selection and characterisation of said novel metabolic pathways enables {B} to be produced enzymatically. The invention provides an alternative to the chemical synthesis of the molecule in question {B}. Moreover, and above all, the invention can be used specifically to target and exploit the only metabolic pathways enabling the transformation of {Ai} into {B}, while eliminating the associated metabolic pathways that can catabolise the target product {B}.

    摘要翻译： 本发明涉及在将底物{Ai}转化为目标产物{B}中具有确定功能的代谢途径的直接选择，其在工业，制药或农业食品领域是感兴趣的。 更具体地，本发明涉及在宏基因组文库中检测参与具有已知产物{B}的生化反应的新生物合成途径。 所述新型代谢途径的选择和表征使得{B}可以酶促产生。 本发明提供了所述分子的化学合成（B）的替代方案。 此外，最重要的是，本发明可以专门用于靶向和利用唯一能够将{Ai}转化为{B}的代谢途径，同时消除可能分解目标产物{B}的相关代谢途径。

    Water Soluble and Activable Phenolics Derivatives with Dermocosmetic and Therapeutic Applications and Process for Preparing Said Derivatives
    5.
    发明申请
    Water Soluble and Activable Phenolics Derivatives with Dermocosmetic and Therapeutic Applications and Process for Preparing Said Derivatives 审中-公开
    具有皮肤科学和治疗应用的水溶性和活性酚类衍生物以及用于制备所述衍生物的方法

    公开(公告)号：US20090233876A1

    公开(公告)日：2009-09-17

    申请号：US12304212

    申请日：2007-06-13

    申请人： Daniel Auriol ,  Renaud Nalin ,  Patrick Robe ,  Fabrice Lefevre

    发明人： Daniel Auriol ,  Renaud Nalin ,  Patrick Robe ,  Fabrice Lefevre

    IPC分类号： A61K31/7048 ,  C12P19/60 ,  C07H17/06 ,  A61P35/00

    CPC分类号： C07H17/075 ,  C07H15/203 ,  C07H15/24 ,  C07H15/26 ,  C12P17/02 ,  C12P19/02 ,  C12P19/44 ,  C12P19/60

    摘要： The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-α-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrhythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic antimutagenic, antineoplastic, anti-thrombotic, and vasodilatory formulations, or in any other field of application.

    摘要翻译： 本发明涉及通过将选自邻苯二酚或其衍生物的酚类与蔗糖的葡萄糖部分的酶缩合制备酚衍生物。 所述酚衍生物的生产通过葡糖基转移酶（EC 2.4.1.5）来实现。 所选择的酚类的这些O-α-葡萄糖苷是新的，在水中的溶解度高于其亲本多酚的溶解度，并且在化妆品和药物组合物中有用，例如抗氧化，抗病毒，抗菌，免疫刺激，抗过敏，抗高血压， 抗缺血性，抗心律不齐，抗血栓形成，低胆固醇血症，抗脂质过氧化物，肝保护，抗炎，抗致癌性抗诱发剂，抗肿瘤剂，抗血栓形成和血管扩张制剂，或在任何其他应用领域。

    Method for extracting DNA from organisms
    6.
    发明授权
    Method for extracting DNA from organisms 有权

    公开(公告)号：US06989249B2

    公开(公告)日：2006-01-24

    申请号：US10282190

    申请日：2002-10-28

    申请人： Renaud Nalin ,  Patrick Robe ,  Van Tran Van

    发明人： Renaud Nalin ,  Patrick Robe ,  Van Tran Van

    IPC分类号： C12P19/34 ,  C12N1/08 ,  C07H21/00 ,  C07H1/08

    CPC分类号： G01N27/44773 ,  C12N15/1003

    摘要： A method for the indirect extraction of DNA greater than 300 kb in size from non-cultivatable organisms contained in an environmental sample is disclosed. The method comprises isolating the organisms from the sample and embedding the isolated organisms in a block of agarose where the organisms are subsequently lysed and the DNA subjected to a first alternating field electrophoresis to extract DNA fragments which are large in size and separate them from the cell debris. The first electrophoretic migration is followed by an enzymatic restriction step and additional electrophoretic migrations. The invention also encompasses DNA obtained by the method.

    Method for the identification of a metabolic pathway family by means of positive selection
    7.
    发明授权
    Method for the identification of a metabolic pathway family by means of positive selection 有权
    通过阳性选择鉴定代谢途径家族的方法

    公开(公告)号：US07846874B2

    公开(公告)日：2010-12-07

    申请号：US10591087

    申请日：2005-03-22

    申请人： Pierre Monsan ,  Claude Bensoussan ,  Philippe Reulet ,  Renaud Nalin ,  Patrick Robe ,  Karine Tuphile ,  Benjamin Gillet ,  Pierre Pujic

    发明人： Pierre Monsan ,  Claude Bensoussan ,  Philippe Reulet ,  Renaud Nalin ,  Patrick Robe ,  Karine Tuphile ,  Benjamin Gillet ,  Pierre Pujic

    IPC分类号： C40B30/04 ,  C40B20/04

    CPC分类号： C12P7/40 ,  C12N2503/02 ,  C12P7/02 ,  C12P13/02 ,  C12P33/00

    摘要： The invention relates to the direct selection of metabolic pathways having a determined function in the transformation of a substrate {Ai} into a target product {B}, which is of interest in the industrial, pharmaceutical or agri-food sectors. More specifically, the invention relates to the detection, within metagenomic libraries, of novel biosynthesis pathways involved in a biochemical reaction having a known product {B}. The selection and characterization of said novel metabolic pathways enables {B} to be produced enzymatically. The invention provides an alternative to the chemical synthesis of the molecule in question {B}. Moreover, and above all, the invention can be used specifically to target and exploit the only metabolic pathways enabling the transformation of {Ai} into {B}, while eliminating the associated metabolic pathways that can catabolise the target product {B}.

    摘要翻译： 本发明涉及在将底物{Ai}转化为目标产物{B}中具有确定功能的代谢途径的直接选择，其在工业，制药或农业食品领域是感兴趣的。 更具体地，本发明涉及在宏基因组文库中检测参与具有已知产物{B}的生化反应的新生物合成途径。 所述新型代谢途径的选择和表征使得{B}可以酶促产生。 本发明提供了所述分子的化学合成（B）的替代方案。 此外，最重要的是，本发明可以专门用于靶向和利用唯一能够将{Ai}转化为{B}的代谢途径，同时消除可能分解目标产物{B}的相关代谢途径。