公开(公告)号：US20060092273A1

公开(公告)日：2006-05-04

申请号：US10795963

申请日：2004-03-07

申请人： David Gere ,  Christopher Burns ,  John Stern ,  Michael Tierney

发明人： David Gere ,  Christopher Burns ,  John Stern ,  Michael Tierney

IPC分类号： H04N13/00 ,  H04N15/00 ,  A61B1/04

CPC分类号： G02B23/2415 ,  A61B1/00183 ,  A61B1/00193 ,  H04N13/10 ,  H04N13/239 ,  H04N13/246 ,  H04N13/296 ,  H04N13/327 ,  H04N2005/2255

摘要： This invention relates to a stereo imaging system for use in telerobotic systems. A method of imaging a target site in a stereo imaging system is provided. The method typically includes capturing a right and a left optical image of the target site and transforming the right and the left optical images preferably into digital information. The method further includes converting the digital information into opposed images of the target site displayed on a stereo display of the stereo imaging system, one of the opposed images being associated with the right optical image and the other of the opposed images being associated with the left optical image. The method further includes regulating the digital information to cause the positions of the target site displayed on the opposed images to change relative to each other. The invention further provides for a method of aligning the opposed images, to a method of adjusting the stereo working distance of an image capture device, such as an endoscope and to a stereo imaging system.

摘要翻译： 本发明涉及一种用于远程遥控系统的立体成像系统。 提供了一种在立体成像系统中成像目标部位的方法。 该方法通常包括捕获目标站点的右光学图像和左光学图像，并将左右光学图像优选地变换为数字信息。 该方法还包括将数字信息转换为立体成像系统的立体显示器上显示的目标站点的相对图像，相对图像中的一个与右光学图像相关联，另一个相对的图像与左侧 光学图像。 所述方法还包括调节所述数字信息以使所述相对图像上显示的所述目标站点的位置相对于彼此改变。 本发明还提供了一种将相对图像对准的方法，一种调整诸如内窥镜和立体成像系统的图像捕获装置的立体声工作距离的方法。

公开(公告)号：US20070285508A1

公开(公告)日：2007-12-13

申请号：US11843871

申请日：2007-08-23

申请人： DAVID GERE ,  Christopher Burns ,  John Stern ,  Michael Tierney

发明人： DAVID GERE ,  Christopher Burns ,  John Stern ,  Michael Tierney

IPC分类号： H04N15/00

CPC分类号： G02B23/2415 ,  A61B1/00183 ,  A61B1/00193 ,  H04N13/10 ,  H04N13/239 ,  H04N13/246 ,  H04N13/296 ,  H04N13/327 ,  H04N2005/2255

摘要： This invention relates to a stereo imaging system for use in telerobotic systems. A method of imaging a target site in a stereo imaging system is provided. The method typically includes capturing a right and a left optical image of the target site and transforming the right and the left optical images preferably into digital information. The method further includes converting the digital information into opposed images of the target site displayed on a stereo display of the stereo imaging system, one of the opposed images being associated with the right optical image and the other of the opposed images being associated with the left optical image. The method further includes regulating the digital information to cause the positions of the target site displayed on the opposed images to change relative to each other. The invention further provides for a method of aligning the opposed images, to a method of adjusting the stereo working distance of an image capture device, such as an endoscope and to a stereo imaging system.

摘要翻译： 本发明涉及一种用于远程遥控系统的立体成像系统。 提供了一种在立体成像系统中成像目标部位的方法。 该方法通常包括捕获目标站点的右光学图像和左光学图像，并将左右光学图像优选地变换为数字信息。 该方法还包括将数字信息转换为立体成像系统的立体显示器上显示的目标站点的相对图像，相对图像中的一个与右光学图像相关联，另一个相对的图像与左侧 光学图像。 所述方法还包括调节所述数字信息以使所述相对图像上显示的所述目标站点的位置相对于彼此改变。 本发明还提供了一种将相对图像对准的方法，一种调整诸如内窥镜和立体成像系统的图像捕获装置的立体声工作距离的方法。

公开(公告)号：US20140156421A1

公开(公告)日：2014-06-05

申请号：US13705838

申请日：2012-12-05

申请人： Christopher Burns ,  John Woolley

发明人： Christopher Burns ,  John Woolley

IPC分类号： G06Q30/02

CPC分类号： G06Q30/0277

摘要： The invention described here is a system and method for efficiently presenting sponsored messages to the user of a participating information site or service, based on the level of interest recently expressed in those messages by other visitors to the same site. Presentation of sponsored messages may also be based on the level of interest expressed by other visitors across the network who are in the individual user's geographic region.

摘要翻译： 这里描述的发明是基于最近在同一站点的其他访问者在这些消息中表达的兴趣水平来有效地向参与信息站点或服务的用户呈现赞助消息的系统和方法。 赞助邮件的呈现也可以基于在个人用户的地理区域中的网络上的其他访问者所表达的兴趣水平。

公开(公告)号：US20070161635A1

公开(公告)日：2007-07-12

申请号：US11711957

申请日：2007-02-27

申请人： Christopher Burns ,  Xianyong Bu ,  Andrew Wilks

发明人： Christopher Burns ,  Xianyong Bu ,  Andrew Wilks

IPC分类号： A61K31/5377 ,  A61K31/497

CPC分类号： C07D401/14 ,  A61K31/497 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04

摘要： Methods using compounds of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof to treat protein kinase-associated disease states is described.

摘要翻译： 描述了使用以下通式的化合物或其药学上可接受的盐，水合物，溶剂合物，结晶形式或非对映异构体来治疗蛋白激酶相关疾病状态的方法。

公开(公告)号：US06173344B2

公开(公告)日：2001-01-09

申请号：US09085671

申请日：1998-05-27

申请人： Abdul Waheed Mohammed ,  Peter K. Cheung ,  Barry Davis ,  Christopher Burns

发明人： Abdul Waheed Mohammed ,  Peter K. Cheung ,  Barry Davis ,  Christopher Burns

IPC分类号： G06F1300

CPC分类号： G06F13/4072

摘要： Disclosed is a SCSI host adapter for use in a computer system. The SCSI host adapter is configured to provide the computer system with interconnection with internal and/or external target devices. The SCSI host adapter includes a low voltage differential connector for interconnecting to a low voltage differential bus, and the low voltage differential bus is configured to communicate a first transaction. The SCSI host adapter also includes a single ended connector for interconnecting to a single ended bus, and the single ended bus is configured to communicate a second transaction. Furthermore, the SCSI host adapter includes a transceiver unit that is configured to interface between the low voltage differential bus and the single ended bus and produce a target information signal. The target information signal is configured to indicate whether the first transaction or the second transaction is occurring between the SCSI host adapter and the low voltage differential bus or the single ended bus.

摘要翻译： 公开了一种用于计算机系统的SCSI主机适配器。 SCSI主机适配器被配置为向计算机系统提供与内部和/或外部目标设备的互连。 SCSI主机适配器包括用于互连到低电压差分总线的低压差分连接器，并且低电压差分总线被配置为传送第一事务。 SCSI主机适配器还包括用于互连到单端总线的单端连接器，并且单端总线被配置为传送第二事务。 此外，SCSI主机适配器包括收发器单元，其被配置为在低电压差分总线和单端总线之间进行接口并产生目标信息信号。 目标信息信号被配置为指示在SCSI主机适配器和低电压差分总线或单端总线之间是否发生第一事务或第二事务。

公开(公告)号：US5889053A

公开(公告)日：1999-03-30

申请号：US5154

申请日：1998-01-09

申请人： Bernard Baudoin ,  Christopher Burns ,  Alain Commercon ,  Alain Lebrun

发明人： Bernard Baudoin ,  Christopher Burns ,  Alain Commercon ,  Alain Lebrun

IPC分类号： A61K31/195 ,  A61K31/215 ,  A61P35/00 ,  A61P43/00 ,  C07C323/59 ,  A61K31/235

CPC分类号： C07C323/59

摘要： Novel farnesyl transferase inhibitors of general formula (I), ##STR1## the preparation thereof and pharmaceutical compositions containing said inhibitors, are disclosed. In general formula (I), R.sub.1 is Y--S--A.sub.1 (where Y is a hydrogen atom, an amino acid residue, a fatty acid residue, an alkyl or alkoxycarbonyl radical or a radical R.sub.4 --S-- where R.sub.4 is a C.sub.1-4 alkyl radical optionally substituted by a phenyl radical or a radical of general formula (II) ##STR2## wherein A.sub.1, X, X.sub.1, Y.sub.1, R'.sub.1, R.sub.2, R'.sub.2 and R are defined as below, and A.sub.1 is a C.sub.1-4 alkylene radical optionally alpha-substituted in the >C(X.sub.1)(Y.sub.1) grouping by an amino or alkylamino, dialkylamino, alkanoylamino or alkoxycarbonylamino radical); X.sub.1 and Y.sub.1 are each a hydrogen atom or, taken together with the carbon atom to which they are attached, form a >C.dbd.O grouping; R'.sub.1 is hydrogen or a C.sub.1-6 alkyl radical; X is an oxygen or sulphur atom; R.sub.2 is a C.sub.1-6 alkyl, alkenyl or alkynyl radical optionally substituted by hydroxyl, alkoxy, mercapto, alkylthio, alkylsulphinyl or alkylsulphonyl, with the proviso that when R.sub.2 is an alkyl radical substituted by a hydroxy radical, R.sub.2 can form a lactone with the .alpha.-carboxy radical; and R'.sub.2 is hydrogen or a C.sub.1-6 alkyl radical; and R is a hydrogen atom or an optionally substituted alkyl radical or an optionally substituted pheny radical, with the proviso that radical (a) ##STR3## is in the 3 or 4 position of the naphthyl ring. The novel products have anticancer properties.

摘要翻译： 公开了通式（I）的新型法呢基转移酶抑制剂，其制备方法和含有所述抑制剂的药物组合物。 在通式（I）中，R 1是YS-A1（其中Y是氢原子，氨基酸残基，脂肪酸残基，烷基或烷氧基羰基或基团R 4 -S-，其中R 4是C 1-4烷基 任选被苯基或通式（II）的基团取代的基团其中A1，X，X1，Y1，R'1，R2，R'2和R定义如下，而A1是 通过氨基或烷基氨基，二烷基氨基，烷酰基氨基或烷氧基羰基氨基，在> C（X1）（Y1）组中任意α-取代的C1-4亚烷基; X1和Y1各自为氢原子，或与它们所连接的碳原子一起形成> C = O基团; R 1是氢或C 1-6烷基; X是氧或硫原子; R2是任选被羟基，烷氧基，巯基，烷硫基，烷基亚磺酰基或烷基磺酰基取代的C 1-6烷基，烯基或炔基，条件是当R 2是被羟基取代的烷基时，R 2可以与 α-羧基; 和R'2是氢或C 1-6烷基; 并且R是氢原子或任选取代的烷基或任选取代的苯基，条件是基团（a）（a）在萘环的3或4位。 新产品具有抗癌性能。

公开(公告)号：US20070082894A1

公开(公告)日：2007-04-12

申请号：US10538499

申请日：2003-12-11

申请人： Christopher Burns ,  Andrew Wilks ,  Xianyong Bu ,  Harrison Sikanyika ,  Michael Harte

发明人： Christopher Burns ,  Andrew Wilks ,  Xianyong Bu ,  Harrison Sikanyika ,  Michael Harte

IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/4965 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

CPC分类号： C07D405/12 ,  C07D241/20 ,  C07D401/12 ,  C07D405/04 ,  C07F9/650952

摘要： A compound of general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating a hyperproliferation-related disease state or disorder in a subject using a compound of formula (I) is also described.

摘要翻译： 描述了通式（I）的化合物或其药学上可接受的前药，盐，水合物，溶剂合物，结晶形式或非对映异构体。 还描述了使用式（I）化合物治疗受试者的过度增生相关疾病状态或障碍的方法。

公开(公告)号：US20060148824A1

公开(公告)日：2006-07-06

申请号：US11367248

申请日：2006-03-02

申请人： Christopher Burns ,  Xianyong Bu ,  Andrew Wilks

发明人： Christopher Burns ,  Xianyong Bu ,  Andrew Wilks

IPC分类号： A61K31/4965

CPC分类号： C07D401/12 ,  C07D241/20 ,  C07D405/12

摘要： A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms of diastereomers thereof is described. Method of inhibiting a protein kinase using compounds of Formula I are also described.

摘要翻译： 描述了以下通式的化合物或其药学上可接受的盐，水合物，溶剂合物，其非对映异构体的晶体形式。 还描述了使用式I化合物抑制蛋白激酶的方法。

公开(公告)号：US06687322B1

公开(公告)日：2004-02-03

申请号：US09680918

申请日：2000-10-06

申请人： Yuheng Zhang ,  Christopher Burns ,  Martin L. Ngu

发明人： Yuheng Zhang ,  Christopher Burns ,  Martin L. Ngu

IPC分类号： H03D324

CPC分类号： H03L7/081 ,  G06F1/12

摘要： The present invention provides a dual mode clock alignment device including a clock buffer cell, a PLL, and a first set and second set of buffers. The clock buffer cell is arranged to receive a first clock and delays the first clock. The PLL is arranged to receive the delayed first clock from the clock buffer and outputs a second clock. The first and second sets of buffers are arranged to receive the delayed first clock from the clock buffer cell for operating in a first clock mode. The first and second sets of buffers are further arranged to receive the second clock from the PLL for operating in a second clock mode. In this arrangement, the first set of buffers delays the received clock by a first delay to output a third clock and the second set of buffers delays the delayed clock by a second delay to output a fourth clock. When operating in the second clock mode, the first, third, and fourth clocks are all aligned.

摘要翻译： 本发明提供一种双模式时钟对准装置，其包括时钟缓冲器单元，PLL以及第一组和第二组缓冲器。 时钟缓冲单元被布置成接收第一时钟并延迟第一时钟。 PLL被布置为从时钟缓冲器接收延迟的第一时钟并输出第二时钟。 第一和第二组缓冲器被布置成从时钟缓冲器单元接收延迟的第一时钟，以在第一时钟模式下操作。 第一和第二组缓冲器还被布置成从PLL接收第二时钟以在第二时钟模式下操作。 在这种布置中，第一组缓冲器将接收到的时钟延迟第一延迟以输出第三时钟，而第二组缓冲器将延迟时钟延迟第二延迟以输出第四时钟。 当在第二时钟模式下操作时，第一，第三和第四时钟都被对准。

公开(公告)号：US06516366B1

公开(公告)日：2003-02-04

申请号：US09580514

申请日：2000-05-25

申请人： Stillman F. Gates ,  Christopher Burns

发明人： Stillman F. Gates ,  Christopher Burns

IPC分类号： G06F1300

CPC分类号： G06F13/385 ,  G06F13/4295

摘要： A host adapter integrated circuit that contains data transfer modules has a serial port that uses a single serial port pin to communicate with a slave serial port input-output integrated circuit that interfaces to various resources that are included in a support circuit. The serial port forms a packet from each byte of information to be transferred from a module to the slave device by adding a start bit before the byte, followed by a parity bit at the end of the byte and followed by a stop bit. After transmitting the packet, the serial port waits for an acknowledge packet from the slave serial port input-output integrated circuit, for example for two clock cycles after transmission of the packet. For synchronous operation, a common oscillator drives the clock signal on the slave serial port input-output integrated circuit and host adapter integrated circuit. The serial port pin in the host adapter integrated circuit is connected to a shifter circuit in the serial port that serially clocks data from the serial port pin and passes the data parallelly to a bus in the host adapter integrated circuit and vice versa.

摘要翻译： 包含数据传输模块的主机适配器集成电路具有串行端口，该串行端口使用单个串行端口引脚与从属串行端口输入 - 输出集成电路通信，该集成电路与支持电路中包含的各种资源进行接口连接。 串行端口通过在字节之前添加一个起始位，随后是字节结尾处的奇偶校验位，后跟一个停止位，形成从要从模块传送到从器件的信息的每个字节的数据包。 在发送数据包之后，串行端口等待来自从串行端口输入 - 输出集成电路的确认数据包，例如传输数据包后的两个时钟周期。 对于同步操作，公共振荡器驱动从串行端口输入输出集成电路和主机适配器集成电路的时钟信号。 主机适配器集成电路中的串行端口引脚连接到串行端口的移位器电路，用于串行地串行串行端口引脚上的数据，并将数据并行传递到主机适配器集成电路中的总线，反之亦然。