公开(公告)号：US20220331209A1

公开(公告)日：2022-10-20

申请号：US17639998

申请日：2020-09-10

Applicant: DENTSPLY SIRONA Inc.

Inventor： Joachim E. KLEE ,  Florian SZILLAT ,  Jacques LALEVÉE ,  Julie KIRSCHNER ,  Fabrice MORLET-SAVARY

IPC: A61K6/887 ,  A61K6/62 ,  A61K8/20 ,  A61K8/46 ,  A61K6/19 ,  A61K6/40

Abstract: The present invention is related to a dental composition comprising: (a) at least one polymerizable monomer having at least one ethylenically unsaturated group; (b) a radical initiator system comprising (i) a photosensitizer having an absorption maximum ranging from 400 nm to 800 nm; (ii) a coinitiator; and (iii) a compound of the following formula (1): wherein R1 and R2, which may be the same or different, independently represent a hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R3 and R4, which may be the same or different, independently represent a hydrogen atom, or a C1-6 alkyl group, or R3 and R4 may represent a bond so that the carbon atoms to which R3 and R4 are bonded are linked by a double bond; R5 and R6, which may be the same or different, independently represent a hydrogen atom, or a C1-6 alkyl group, or R5 and R6 may represent a bond so that the carbon atoms to which R5 and R6 are bonded are linked by a double bond; L represents a single bond or a group —CRH—, wherein R may be a hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; n and m, independently are integers of 1 to 6.

公开(公告)号：US20180303722A1

公开(公告)日：2018-10-25

申请号：US15766382

申请日：2016-10-07

Applicant: DENTSPLY SIRONA Inc.

Inventor： Joachim E. KLEE ,  Florian SZILLAT ,  Maximilian MAIER ,  Helmut RITTER ,  Jacques LALEVEE ,  Jean Pierre FOUASSIER ,  Fabrice MORLET-SAVARY ,  Celine DIETLIN ,  Mariem BOUZRATI-ZERELLI ,  Christoph P FIK

IPC: A61K6/00 ,  A61K6/083

Abstract: The present invention relates to a dental composition comprising a specific polymerization initiator system comprising a compound having an acylsilyl- or acylgermanyl-group. The present invention also relates the use of the compound having an acylsilyl- or acylgermanyl group for the preparation of a dental composition.

公开(公告)号：US20180228701A1

公开(公告)日：2018-08-16

申请号：US15951319

申请日：2018-04-12

Applicant: DENTSPLY SIRONA Inc.

Inventor： Joachim E. KLEE ,  Helmut RITTER ,  Maximilliam MAIER ,  Julia GANSEL ,  Andreas FACHER ,  Oliver ELSNER ,  Sven POHLE

IPC: A61K6/083 ,  C08F8/12 ,  C08F8/00 ,  C08F8/46 ,  C08F220/06 ,  C08F220/18 ,  C08F220/12 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26

CPC classification number: A61K6/0835 ,  C08F8/00 ,  C08F8/12 ,  C08F8/46 ,  C08F220/06 ,  C08F220/18 ,  C08F220/12 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26

Abstract: A process for producing a water-soluble, hydrolysis-stable, polymerizable polymer, comprising a) a step of copolymerizing a mixture comprising (i) a first copolymerizable monomer comprising at least one optionally protected carboxylic acid group and a first polymerizable organic moiety, and (ii) a second copolymerizable monomer comprising one or more optionally protected primary and/or secondary amino groups and a second polymerizable organic moiety, for obtaining an amino group containing copolymer; b) a step of coupling to the amino group containing copolymer a compound having a polymerizable moiety and a functional group reactive with an amino group of repeating units derived from the second copolymerizable monomer in the amino group containing copolymer obtained in the first step wherein the optionally protected amino group is deprotected, so that polymerizable pendant groups are linked to the backbone by hydrolysis-stable linking groups, and, optionally, a step of deprotecting the protected carboxylic acid group after step (a) or step (b), for obtaining a polymerizable polymer.

公开(公告)号：US20200157266A1

公开(公告)日：2020-05-21

申请号：US16555217

申请日：2019-08-29

Applicant: DENTSPLY SIRONA Inc.

Inventor： Xiaoming JIN ,  Christian Scheufler ,  Joachim E. KLEE ,  Hui LU

IPC: C08F220/60 ,  C08F293/00 ,  C08J3/075 ,  A61K6/083

Abstract: Described herein are a polymerizable antibacterial nanogel and hydrolytically stable antibacterial nanogel composition and methods of preparing such compositions, use of polymerizable antibacterial nanogels and hydrolytically stable antibacterial nanogels as additives to a dental product, such as a resin monomer, a cement, an adhesive and composite formulations. Methods and compositions for forming hydrolytically stable antibacterial monomers are also described.

公开(公告)号：US20180289592A1

公开(公告)日：2018-10-11

申请号：US15766397

申请日：2016-10-10

Applicant: DENTSPLY SIRONA Inc.

Inventor： Joachim E. KLEE ,  Florian SZILLAT ,  Maximilian MAIER ,  Helmut RITTER ,  Jacques LALEVEE ,  Jean Pierre FOUASSIER ,  Fabrice MORLET-SAVARY ,  Celine DIETLIN ,  Mariem BOUZRATI-ZERELLI ,  Christoph P. FIK

IPC: A61K6/083 ,  A61K6/00

CPC classification number: A61K6/083 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0052 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26

Abstract: The present invention relates to a dental composition comprising an initiator system comprising a sensitizer compound having an acylsilyl- or acylgermyl-group and a specific coinitiator compound. The present invention also relates to an initiator system consisting essentially of the sensitizer compound having an acylsilyl- or acylgermyl-group and a coinitiator compound wherein a C—H bond dissociation energy is less than 95 Kcal/mol. Furthermore, the present invention relates to the use of this initiator system for the preparation of a dental composition.

公开(公告)号：US20250161169A1

公开(公告)日：2025-05-22

申请号：US18921646

申请日：2024-10-21

Applicant: DENTSPLY SIRONA Inc.

Inventor： Joachim E. KLEE ,  Matthias WORM ,  Christian SCHEUFLER ,  Oilver ELSNER ,  Thomas TIGGES

IPC: A61K6/893 ,  A61K6/30 ,  A61K6/62 ,  A61K6/889 ,  C08L35/02

Abstract: Described herein is a dental composition containing a polymerizable compound having at least one optionally derivatized β-hydroxy urethane unit. The polymerizable compound having at least one optionally derivatized β-hydroxy urethane unit is obtained without use of organo-metal catalysts and isocyanates and by a reaction between an at least one component A having at least one cyclic carbonate group with an at least one component B having at least one of primary amine functional group and secondary amine functional group. The present disclosure relates to use of the polymerizable compound having at least one optionally derivatized β-hydroxy urethane unit for the preparation of a dental composition, in particular a dental composite, a glass ionomer, a dental cement, a dental sealant, and a dental adhesive.

公开(公告)号：US20240180791A1

公开(公告)日：2024-06-06

申请号：US18436539

申请日：2024-02-08

Applicant: DENTSPLY SIRONA Inc.

Inventor： Christoph FIK ,  Maximilian MAIER ,  Joachim E. KLEE ,  Christian SCHEUFLER

IPC: A61K6/838 ,  A61K6/79

CPC classification number: A61K6/838 ,  A61K6/79

Abstract: The present invention relates to a dental composition comprising a specific radically polymerizable compound and a radical initiator system. Furthermore, the present invention relates to the specific radically polymerizable compound and its use in a dental composition. The specific radically polymerizable compound of the present invention has an allyl (meth)acrylamide group and a phosphoric acid ester group.

公开(公告)号：US20210069070A1

公开(公告)日：2021-03-11

申请号：US16642259

申请日：2018-08-30

Applicant: DENTSPLY SIRONA INC.

Inventor： Maximilian MAIER ,  Joachim E. KLEE ,  Christian SCHEUFLER ,  Caroline RENN ,  Florian SZILLAT

IPC: A61K6/889 ,  C08F220/64 ,  A61K6/62 ,  C08F8/32

Abstract: The present invention relates to an initiator modified polyacidic polymer having a covalently bonded initiator compound, and to a dental resin-modified glass ionomer composition comprising this polyacidic polymer. Furthermore, the present invention relates to a use of the initiator modified polyacidic polymer for the preparation of a dental composition.
The covalently bonded initiator compound of the initiator modified polyacidic polymer may be any compound of a redox initiator system, a photoinitiator system, for example a Norrish type I or II photoinitiator, an electron donor component, a sensitizer component or a coinitiator component.

公开(公告)号：US20200069530A1

公开(公告)日：2020-03-05

申请号：US16554695

申请日：2019-08-29

Applicant: DENTSPLY SIRONA Inc.

Inventor： Xiaoming JIN ,  Bassam USTA ,  Christian Scheufler ,  Joachim E. KLEE ,  Thomas TIGGES ,  Kira NEUHAUS ,  Jörg Brenneisen ,  Hui LU

IPC: A61K6/00 ,  A61K6/083 ,  C08L33/14

Abstract: The present disclosure relates to methods and compositions to stabilize a nanogel and use of such nanogel as additives in dental compositions.

公开(公告)号：US20190224081A1

公开(公告)日：2019-07-25

申请号：US15898933

申请日：2018-02-19

Applicant: DENTSPLY SIRONA INC.

Inventor： Hui LU ,  Xiaoming JIN ,  Joachim E. KLEE ,  Bernard KOLTISKO

IPC: A61K6/083 ,  A61K6/00 ,  C07D295/24

Abstract: A method of forming a dental composite includes photopolymerizing a dental composition. The dental composition includes a free-radically polymerizable (meth)acrylate resin, 75 percent by weight or greater of filler particles, and about 0.005 percent to about 5 percent by weight of at least one polymerizable stable radical. The photopolymerizing forms the dental composite such that the dental composite has a flexural modulus of about 9500 MPa or greater and the polymerizable stable radical reduces shrinkage stress of the dental composite caused by the photopolymerizing by 10% or greater. A method of forming a dental composite composition includes combining a free-radically polymerizable (meth)acrylate resin, 75 percent by weight or greater of filler particles, and about 0.005 percent to about 5 percent by weight of at least one polymerizable stable radical to form the dental composite composition.