公开(公告)号：US20170233480A1

公开(公告)日：2017-08-17

申请号：US15393534

申请日：2016-12-29

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： JIANN-SHIUN LAI ,  LI-SHUANG AI ,  YAN-DA LAI ,  YEN-YU WU ,  YI-SAN TSAI ,  YI-JIUE TSAI ,  JUO-YU HUANG ,  CHENG-CHOU YU ,  CHUAN-LUNG HSU ,  CHIEN-TSUN KUAN ,  SZU-LIANG LAI ,  LI-YA WANG

IPC: C07K16/28 ,  G01N33/74 ,  C07K16/30 ,  A61K31/4439 ,  A61K51/10

CPC classification number: C07K16/2863 ,  A61K31/4439 ,  A61K47/6803 ,  A61K47/6849 ,  A61K51/1027 ,  A61K51/1096 ,  A61K2039/505 ,  A61K2039/507 ,  C07K14/71 ,  C07K16/005 ,  C07K16/2818 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/74 ,  G01N2333/71

Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.