公开(公告)号：US20220148866A1

公开(公告)日：2022-05-12

申请号：US17427300

申请日：2020-02-03

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. Covey ,  Chang Liu ,  Gary J. Van Berkel

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/06

Abstract: A method for the repeated analysis of a sample bearing location. The sample bearing location may include, for instance, a sampled point in a tissue slice that is spatially and temporally correlated to the original slice. The slice may be in whole, or in part, a complete item or a portion of a complete item such as, for example, a human organ. The method improves the analysis process, such as mass spectrometry analysis, by providing a much more complete characterization of the target. The method also allows for the splitting of the sample and chemical/physical alteration of the aliquots for enhanced chemical analysis.

公开(公告)号：US09176028B2

公开(公告)日：2015-11-03

申请号：US13644941

申请日：2012-10-04

Applicant: UT-BATTELLE, LLC ,  DH Technologies Development Pte. Ltd.

Inventor： Mariam S. ElNaggar ,  Gary J. Van Berkel ,  Thomas R. Covey

IPC: G01N1/14 ,  G01N1/02

CPC classification number: G01N1/14 ,  G01N2001/028

Abstract: A system for sampling a surface includes a sampling probe having a housing and a socket, and a rolling sampling sphere within the socket. The housing has a sampling fluid supply conduit and a sampling fluid exhaust conduit. The sampling fluid supply conduit supplies sampling fluid to the sampling sphere. The sampling fluid exhaust conduit has an inlet opening for receiving sampling fluid carried from the surface by the sampling sphere. A surface sampling probe and a method for sampling a surface are also disclosed.

Abstract translation: 用于对表面进行采样的系统包括具有壳体和插座的采样探针以及插座内的滚动采样球。 壳体具有取样流体供应管道和采样流体排出管道。 采样流体供应管道将采样流体提供给采样球体。 取样流体排出管道具有入口开口，用于接收由取样球体从表面携带的取样流体。 还公开了表面采样探针和用于对表面进行取样的方法。

公开(公告)号：US11990325B2

公开(公告)日：2024-05-21

申请号：US17427300

申请日：2020-02-03

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. Covey ,  Chang Liu ,  Gary J. Van Berkel

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/06

CPC classification number: H01J49/0004 ,  H01J49/0418 ,  H01J49/0431 ,  H01J49/063

Abstract: A method for the repeated analysis of a sample bearing location. The sample bearing location may include, for instance, a sampled point in a tissue slice that is spatially and temporally correlated to the original slice. The slice may be in whole, or in part, a complete item or a portion of a complete item such as, for example, a human organ. The method improves the analysis process, such as mass spectrometry analysis, by providing a much more complete characterization of the target. The method also allows for the splitting of the sample and chemical/physical alteration of the aliquots for enhanced chemical analysis.

公开(公告)号：US20240087865A1

公开(公告)日：2024-03-14

申请号：US18254625

申请日：2021-11-30

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Gary J. Van Berkel

IPC: H01J49/04

CPC classification number: H01J49/0431

Abstract: The disclosure provides systems and methods for segmented flow analysis. More particularly, the disclosure relates to introducing a liquid sample and a segmenting liquid into a transport capillary for segmented flow analysis, wherein the liquid sample and/or the segmenting liquid are dispensed into the transport capillary as discrete droplets.

公开(公告)号：US20240021425A1

公开(公告)日：2024-01-18

申请号：US18254617

申请日：2021-11-30

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Gary J. Van Berkel

IPC: H01J49/04

CPC classification number: H01J49/0431

Abstract: The disclosure provides systems and methods for introducing a sample into an open port interface of an analytical device. More particularly, the disclosure relates to a sampling system that includes a dispenser, a hollow tip that releasably couples to the dispenser, and a gantry for receiving the tip. The gantry can be mounted to the open port interface of an analytical device.