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公开(公告)号：US20240249930A1
公开(公告)日：2024-07-25
申请号：US18156502
申请日：2023-01-19
Inventor： Dmitry Grinfeld , Eric Wapelhorst , Alexander Makarov , Michael Roukes
IPC: H01J49/06
CPC classification number: H01J49/063
Abstract: An ion focusing device comprising an ion collection element comprising a plurality of N curved electrodes extending around an axis of the ion collection element and an aperture on an axis of the ion collection element. A multipole ion guide adjacent the ion collection element and having a plurality of N elongate electrodes extending parallel to and around an axis of the multipole ion guide, wherein the axis of the multipole ion guide coincides with the axis of the ion collection element, wherein each of the N curved electrodes of the ion collection element are configured to receive a radio frequency, RF, signal having the same phase as an RF signal configured to be applied to at least one elongate electrode of the plurality of elongate electrodes of the multipole ion guide, and further wherein at least two of the N electrodes of the ion collection element are configured to receive RF signals of a different phase.
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公开(公告)号：US20240234121A1
公开(公告)日：2024-07-11
申请号：US18610172
申请日：2024-03-19
Applicant: Thermo Fisher Scientific (Bremen) GmbH
Inventor： Jan-Peter Hauschild , Amelia Corinne Peterson , Aivaras Venckus
CPC classification number: H01J49/063 , B08B9/0436 , H01J49/4255
Abstract: A cleaning device for cleaning electrodes of an ion optical multipole device comprises at least one substantially longitudinal cleaning section, at least one handling section extending axially from the at least one cleaning section and at least one direction section extending axially from the at least one cleaning section. The at least one cleaning section has a larger cross section than the at least one handling section. The at least one direction section is capable of allowing a longitudinal movement of the cleaning device in a first axial direction and resisting a longitudinal movement of the cleaning device in a second, opposite axial direction.
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3.发明公开公开(公告)号：US20240162022A1
公开(公告)日：2024-05-16
申请号：US18283109
申请日：2022-03-24
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Yves LE BLANC
CPC classification number: H01J49/0045 , H01J49/022 , H01J49/063 , H01J49/24
Abstract: Systems and methods described herein provide for charge state control of multiply-charged anions in a front end, high pressure ion guide. In some example aspects, a mass spectrometer system is provided comprising a first vacuum chamber (121) maintained at a pressure above about 500 mTorr. At least one ion guide (106) is disposed within the first vacuum chamber, the at least one ion guide comprising a plurality of rods extending along a central longitudinal axis. A controller (193) is configured to adjust an amplitude of an RF voltage signal provided to the plurality of rods so as to alternatively operate the ion guide in a first mode of operation with a lower amplitude of the RF voltage signal so as to reduce the likelihood of charge reduction by electron detachment so as to substantially maintain the isotopic distribution of the ions during transmission of ions through the ion guide, and a second mode of operation with a higher amplitude of the RF voltage signal so as to increase the likelihood of electron detachment from ions being transmitted therethrough.
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公开(公告)号：US11961729B2
公开(公告)日：2024-04-16
申请号：US16875900
申请日：2020-05-15
Applicant: Thermo Fisher Scientific (Bremen) GmbH
Inventor： Jan-Peter Hauschild , Amelia Corinne Peterson , Aivaras Venckus
CPC classification number: H01J49/063 , B08B9/0436 , H01J49/4255
Abstract: A cleaning device for cleaning electrodes of an ion optical multipole device comprises at least one substantially longitudinal cleaning section, at least one handling section extending axially from the at least one cleaning section and at least one direction section extending axially from the at least one cleaning section. The at least one cleaning section has a larger cross section than the at least one handling section. The at least one direction section is capable of allowing a longitudinal movement of the cleaning device in a first axial direction and resisting a longitudinal movement of the cleaning device in a second, opposite axial direction.
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公开(公告)号：US11810771B2
公开(公告)日：2023-11-07
申请号：US16482476
申请日：2018-01-29
Applicant: DH Technologies Development Pte. Ltd.
Inventor： James Hager
CPC classification number: H01J49/0031 , H01J49/063 , H01J49/067 , H01J49/427
Abstract: In one aspect, a mass analyzer is disclosed, which comprises a quadrupole having an input end for receiving ions and an output end through which ions can exit the quadrupole, said quadrupole having a plurality of rods to at least some of which an RF voltage can be applied for generating a quadrupolar field for causing radial confinement of the ions as they propagate through the quadrupole and further generating fringing fields in proximity of said output end. The mass analyzer further includes at least a voltage source for applying a voltage pulse to at least one of said rods so as to excite radial oscillations of at least a portion of the ions passing through the quadrupole at secular frequencies thereof, where the radially-excited ions interact with the fringing fields as they exit the quadrupole such that their radial oscillations are converted into axial oscillations.
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Patent Agency Ranking
公开(公告)号：US20230326729A1
公开(公告)日：2023-10-12
申请号：US18333174
申请日：2023-06-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Benjamin Tiemann , Daniel Intelmann
CPC classification number: H01J49/0009 , H01J49/063 , H01J49/0031 , H01J49/009 , G01N30/724
Abstract: A method for optimizing at least one parameter setting of at least one mass spectrometry device (110) operating at unit resolution is disclosed. The method comprises the following steps:
a) determining at least one analyte detection window for detecting an analyte of interest with the mass spectrometry device (110), wherein the analyte detection window is defined by a central mass to charge ratio value of the analyte and a predefined width, wherein the central mass to charge ratio value of the analyte is set to a theoretical mass to charge ratio value of the analyte of interest having more than one decimal place and/or a mass to charge ratio value of the analyte of interest determined by a high resolution mass spectrometry measurement having more than one decimal place;
b) determining at least one internal standard detection window for detecting an internal standard substance with the mass spectrometry device (110), wherein the internal standard detection window is defined by a central mass to charge ratio value of the internal standard substance and the pre-defined width, wherein the central mass to charge ratio value of the internal standard substance is set to a mass to charge ratio value of the internal standard substance calculated relative to the analyte of interest and having more than one decimal place and/or to a mass to charge ratio value of the internal standard substance determined by a high resolution mass spectrometry measurement having more than one decimal place.-
公开(公告)号：US11756780B2
公开(公告)日：2023-09-12
申请号：US17541086
申请日：2021-12-02
Applicant: Thermo Finnigan LLC
Inventor： Harald Oser , Raman Mathur
CPC classification number: H01J49/063 , H01J49/065 , H01J49/4225
Abstract: A first multipole assembly includes a first plurality of rod electrodes arranged about an axis and configured to confine ions radially about the axis. A second multipole assembly disposed adjacent to the first multipole assembly includes a second plurality of rod electrodes arranged about the axis and configured to confine the ions radially about the axis. An orientation of the first multipole assembly about the axis is rotationally offset relative to an orientation of the second multipole assembly about the axis.
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公开(公告)号：US11728155B2
公开(公告)日：2023-08-15
申请号：US17612502
申请日：2020-05-19
Applicant: Thermo Fisher Scientific (Bremen) GmbH
Inventor： Henning Wehrs , Johannes Schwieters , Gerhard Jung
CPC classification number: H01J49/063 , F16K1/2007 , H01J49/005 , H01J49/0077 , H01J49/022 , H01J49/065 , H01J49/067 , H01J49/068 , H01J49/105 , H01J49/421 , H01J49/4215
Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises electrodes (11, 12, 14) comprising a multipole arrangement defining an ion optical axis, and a voltage source for providing voltages to the electrodes to produce electric fields. The ion optical arrangement is configured for producing a radio frequency electric focusing field for focusing ions on the ion optical axis. The radio frequency electric focusing field has a varying frequency so as to reduce any mass dependence of ion trajectories through the ion optical arrangement. The ion optical arrangement may further be configured for producing a static electric field in response to a DC bias voltage applied to the multipole arrangement. A superimposed varying electric field may be produced by superimposing an AC voltage upon the DC bias voltage.
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公开(公告)号：US20230178354A1
公开(公告)日：2023-06-08
申请号：US17913225
申请日：2021-03-19
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Aaron T. BOOY
IPC: H01J49/06
CPC classification number: H01J49/063 , H01J49/068
Abstract: In one aspect, an ion guide assembly for use in a mass spectrometry system is disclosed, which comprises a first plurality of multipole rods that are arranged to allow passage of ions therebetween, a second plurality of multipole rods that are arranged to allow passage of ions therebetween, and a board disposed between the first and second plurality of rods, the board comprising an ion lens. The first and second plurality of rods are coupled to the board, and the rods of the first plurality of rods are pairwise aligned with, and coupled to, rods of the second plurality of rods.
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公开(公告)号：US11664209B2
公开(公告)日：2023-05-30
申请号：US17516790
申请日：2021-11-02
Applicant: SHIMADZU CORPORATION
Inventor： Matthew Gill , Stephen Bloomfield , Richard Witter
CPC classification number: H01J49/068 , H01J49/063 , H01J49/4215 , H01J49/4225
Abstract: A method of manufacturing a multipole device includes the steps of: (a) forming an intermediate device by assembling a plurality of components including a plurality of precursor multipole electrodes, wherein the plurality of precursor multipole electrodes in the assembled device extend along and are distributed around a central axis; (b) forming a multipole device from the intermediate device by machining the precursor multipole electrodes within the intermediate device to provide a plurality of multipole electrodes having a predetermined spatial relationship; wherein a first component of the multipole device that includes a multipole electrode is attached non-permanently to a second component of the multipole device, the first component including a first alignment formation, and the second component including a second alignment portion configured to engage with the first alignment formation on the first component so as to facilitate alignment of the first component and the second component when the first component and the second component are attached, thereby allowing the first component to be detached from and then reattached to the second component while retaining the predetermined spatial relationship between the plurality of multipole electrodes.
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