公开(公告)号：US20190388558A1

公开(公告)日：2019-12-26

申请号：US16174902

申请日：2018-10-30

Applicant: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： GUN IL IM ,  MI LAN KANG

IPC: A61K47/69 ,  A61K31/728 ,  A61K47/60 ,  A61K9/00 ,  A61P19/02

Abstract: The present invention relates to a polymeric micelle including a kartogenin derivative, a hyaluronic acid hydrogel including the same, a method for producing the same, and a use thereof, and the polymeric micelle and the hyaluronic acid derivative hydrogel including the polymeric micelle slowly release kartogenin, and thus may be usefully used for the purpose of preventing or treating various cartilage disorder-related diseases such as degenerative arthritis because an effect of regenerating chondrocytes while protecting chondrocytes is excellent.

公开(公告)号：US20240082309A1

公开(公告)日：2024-03-14

申请号：US18002101

申请日：2021-06-18

Applicant: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： GUN IL IM ,  EU GENE LEE

IPC: A61K35/28 ,  A61P19/08 ,  C12N9/10 ,  C12N15/85

CPC classification number: A61K35/28 ,  A61P19/08 ,  C12N9/1007 ,  C12N15/85 ,  C12Y201/01251 ,  C12N2800/107

Abstract: The present invention relates to a composition for bone regeneration comprising METTL7A-overexpressing stem cells, a method for preparing the same, and a cell therapy product comprising the same. According to the invention, it is possible to enhance the osteogenic differentiation ability and viability of stem cells compared to conventional stem cell therapy products for bone regeneration.

公开(公告)号：US20190224241A1

公开(公告)日：2019-07-25

申请号：US16097698

申请日：2017-06-16

Applicant: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： GUN IL IM ,  JONG MIN LEE ,  JI YUN KO

IPC: A61K35/28 ,  C07K14/47 ,  C12N15/85 ,  A61K48/00

Abstract: The present invention relates to a non-viral minicircle vector expressing a SOX gene, a stem cell into which the vector is introduced, a pharmaceutical composition for preventing or treating a cartilage disease, including the stem cell, and a method for constructing the vector. The transformation of mesenchymal stem cells with MC/SOX-Trio or MC/SOX-Duo, which is a non-viral minicircle vector according to the present invention, can completely exclude the necessity of expensive growth factors that have been indispensably used in inducing the differentiation of mesenchymal stem cells into chondrocytes. Accordingly, the mesenchymal stem cells transformed therewith, when implanted in vivo, can differentiate into chondrocytes by themselves, and thus have an advantage capable of simplifying the existing complicated steps of culturing cells to induce differentiation and then transplanting the cells.Further, unlike existing vector systems in which antibiotic-resistant genes and other bacteria-derived exogenous genes are simultaneously transferred to cells even after transformation, the vector of the present invention minimizes transfer of unnecessary genes into target cells by allowing two or three SOX genes necessary only for differentiation into chondrocytes to be regulated under one promoter, and thus can be utilized as a non-viral vector system in the most advantageous form for use in clinical application of stem cell-gene therapeutic agents.