公开(公告)号：US20140311891A1

公开(公告)日：2014-10-23

申请号：US14322113

申请日：2014-07-02

Applicant: DREXEL UNIVERSITY

Inventor： GREGORY FRIDMAN ,  ALEXANDER FRIDMAN ,  ALEXANDER F. GUTSOL ,  GENNADY FRIEDMAN ,  DAVID STAACK

IPC: B01J19/08

CPC classification number: A61L2/14 ,  A61L2/0011 ,  B01J19/087 ,  H05H1/2406 ,  H05H2001/245 ,  H05H2001/2456 ,  H05H2245/122

Abstract: Disclosed is a device and method for contacting a biological substrate. A non-thermal plasma device delivers a non-thermal plasma discharge using a dielectric conduit, an igniter electrode and a RF electrode. The dielectric conduit fluidicly communicates a gas therethrough and an igniter electrode ionizes at least a portion of the gas. The RF electrode, disposed circumferentially proximate to the exterior of the dielectric conduit, generates non-thermal plasma from the ionized gas. The non-thermal plasma is discharged from the dielectric conduit and contacts a biological substrate. The non-thermal plasma discharge may be suitable for tissue bonding and sterilization applications.

Abstract translation: 公开了一种用于接触生物底物的装置和方法。 非热等离子体装置使用电介质导管，点火器电极和RF电极来传送非热等离子体放电。 电介质导管使气体通过其流体连通，并且点火器电极使至少一部分气体电离。 沿电介质导管的外部周向设置的RF电极从电离气体产生非热等离子体。 非热等离子体从电介质导管排出并与生物基板接触。 非热等离子体放电可适用于组织粘合和灭菌应用。

公开(公告)号：US20170202218A1

公开(公告)日：2017-07-20

申请号：US15421918

申请日：2017-02-01

Applicant: DREXEL UNIVERSITY

Inventor： GREGORY FRIDMAN ,  SIN PARK ,  NATALIE SHAINSKY ,  DANIL V. DOBRYNIN ,  ALEXANDER RABINOVICH ,  GENNADY FRIEDMAN ,  ALEXANDER FRIDMAN ,  MOOGEGA COOPER ,  ARI D. BROOKS ,  SURESH G. JOSHI ,  ALEXANDER E. POOR ,  UTKU K. ERCAN ,  MARK INGERMAN

IPC: A01N37/46 ,  A61L2/00 ,  A01N43/16 ,  A61L2/22 ,  A61L2/14

CPC classification number: A01N37/46 ,  A01N37/30 ,  A01N43/16 ,  A01N61/00 ,  A61L2/0011 ,  A61L2/14 ,  A61L2/16 ,  A61L2/22 ,  A61L2202/24 ,  A01N25/02 ,  A01N25/34

Abstract: Aspects of the present subject matter are directed to a method comprising contacting an fluid, optionally containing an added organic material, with a non-thermal plasma to form a disinfection composition, wherein the disinfection composition is a liquid, and contacting a surface with the disinfection composition, wherein the surface is at least partially disinfected upon contact with the disinfection composition. Additional aspects of the present subject matter are directed to a method comprising forming a disinfection composition by contacting an organic material with a non-thermal plasma, wherein the disinfection composition is a liquid. A further aspect of the present subject matter is directed to a disinfection composition comprising an organic material contacted by a non-thermal plasma, wherein the disinfection composition is a liquid.

公开(公告)号：US20140314621A1

公开(公告)日：2014-10-23

申请号：US14322131

申请日：2014-07-02

Applicant: DREXEL UNIVERSITY

Inventor： GREGORY FRIDMAN ,  ALEXANDER FRIDMAN ,  ALEXANDER F. GUTSOL ,  GENNADY FRIEDMAN

IPC: A61L2/03

CPC classification number: A61L2/03 ,  A61L2/14 ,  A61L2202/24

Abstract: Methods and devices for treating surfaces of objects using a non-thermal plasma are disclosed herein. The non-thermal plasma is generated through the use of an apparatus configured to generate a non-thermal plasma on its surface. The apparatus is comprised of a substrate that contains one or more electrodes of different polarity. The electrodes are placed within a layer of the substrate acting as a dielectric layer. The apparatus may also have additional layers to contain the dielectric layer. When an appropriate potential, being either an alternating current or pulsed high voltage potential, is applied and removed from the one or more electrodes, the gas on at least one surface of the apparatus becomes ionized and forms a non-thermal plasma. The electrodes can be configured to be of various shapes and sizes to modify or tune the plasma.

Abstract translation: 本文公开了使用非热等离子体处理物体表面的方法和装置。 通过使用被配置为在其表面上产生非热等离子体的装置来产生非热等离子体。 该装置由含有一个或多个不同极性的电极的基板组成。 电极被放置在用作电介质层的衬底的层内。 该装置还可以具有附加层以容纳电介质层。 当从一个或多个电极施加或移除作为交流或脉冲高电压电位的适当电位时，装置的至少一个表面上的气体被离子化并形成非热等离子体。 电极可以被配置为具有各种形状和尺寸以修改或调谐等离子体。

公开(公告)号：US20160193373A1

公开(公告)日：2016-07-07

申请号：US15067715

申请日：2016-03-11

Applicant: DREXEL UNIVERSITY

Inventor： GREGORY FRIDMAN ,  ALEXANDER FRIDMAN ,  ALEXANDER F. GUTSOL ,  GENNADY FRIEDMAN ,  DAVID STAACK

IPC: A61L2/14 ,  H05H1/24 ,  A61L2/00

CPC classification number: A61L2/14 ,  A61L2/0011 ,  B01J19/087 ,  H05H1/2406 ,  H05H2001/245 ,  H05H2001/2456 ,  H05H2245/122

Abstract: Disclosed is a device and method for contacting a biological substrate. A non-thermal plasma device delivers a non-thermal plasma discharge using a dielectric conduit, an igniter electrode and a RF electrode. The dielectric conduit fluidicly communicates a gas therethrough and an igniter electrode ionizes at least a portion of the gas. The RF electrode, disposed circumferentially proximate to the exterior of the dielectric conduit, generates non-thermal plasma from the ionized gas. The non-thermal plasma is discharged from the dielectric conduit and contacts a biological substrate. The non-thermal plasma discharge may be suitable for tissue bonding and sterilization applications.

Abstract translation: 公开了一种用于接触生物底物的装置和方法。 非热等离子体装置使用电介质导管，点火器电极和RF电极来传送非热等离子体放电。 电介质导管使气体通过其流体连通，并且点火器电极使至少一部分气体电离。 沿电介质导管的外部周向设置的RF电极从电离气体产生非热等离子体。 非热等离子体从电介质导管排出并与生物基板接触。 非热等离子体放电可适用于组织粘合和灭菌应用。

公开(公告)号：US20130310731A1

公开(公告)日：2013-11-21

申请号：US13950614

申请日：2013-07-25

Applicant: DREXEL UNIVERSITY

Inventor： ALEXANDER F. GUTSOL ,  ALEXANDER FRIDMAN ,  GENNADY FRIEDMAN ,  GREGORY FRIDMAN

IPC: A61B18/04

CPC classification number: A61B18/042 ,  A61N1/40 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2240/20 ,  H05H2245/122

Abstract: Method for the non-thermal treatment of human or animal tissue with high-voltage electrical discharge plasma is disclosed. The disclosed method employs current through plasma and through tissue not for the purpose of heating the tissue, but instead to maintain the plasma proximate to the tissue being treated. Also disclosed is a method of limiting the current through plasma and through tissue to minimize tissue heating by placement of an insulator or semiconductor between an electrode and tissue resulting in generation of a high-voltage discharge similar to a dielectric barrier discharge. The disclosed non-thermal plasma treatment can be employed to promote coagulation of blood, sterilization, disinfection, re-connection of tissue, and treatment of tissue disorders without causing significant thermal tissue damage.

Abstract translation: 公开了用高压放电等离子体对人体或动物组织进行非热处理的方法。 所公开的方法采用电流通过等离子体和通过组织而不是用于加热组织的目的，而是将血浆保持在靠近待治疗组织的位置。 还公开了一种限制通过等离子体和通过组织的电流的方法，以通过在电极和组织之间放置绝缘体或半导体来最小化组织加热，导致产生类似于电介质阻挡放电的高压放电。 所公开的非热等离子体处理可用于促进血液凝结，消毒，消毒，组织再连接，以及治疗组织疾病而不引起明显的热组织损伤。