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    TUBULAR FLOATING ELECTRODE DIELECTRIC BARRIER DISCHARGE FOR APPLICATIONS IN STERILIZATION AND TISSUE BONDING
    1.
    发明申请
    TUBULAR FLOATING ELECTRODE DIELECTRIC BARRIER DISCHARGE FOR APPLICATIONS IN STERILIZATION AND TISSUE BONDING 有权
    用于灭菌和组织结合的管状浮动电极介质阻挡放电

    公开(公告)号：US20140311891A1

    公开(公告)日：2014-10-23

    申请号：US14322113

    申请日：2014-07-02

    Applicant: DREXEL UNIVERSITY

    Inventor： GREGORY FRIDMAN ,  ALEXANDER FRIDMAN ,  ALEXANDER F. GUTSOL ,  GENNADY FRIEDMAN ,  DAVID STAACK

    IPC: B01J19/08

    CPC classification number: A61L2/14 ,  A61L2/0011 ,  B01J19/087 ,  H05H1/2406 ,  H05H2001/245 ,  H05H2001/2456 ,  H05H2245/122

    Abstract: Disclosed is a device and method for contacting a biological substrate. A non-thermal plasma device delivers a non-thermal plasma discharge using a dielectric conduit, an igniter electrode and a RF electrode. The dielectric conduit fluidicly communicates a gas therethrough and an igniter electrode ionizes at least a portion of the gas. The RF electrode, disposed circumferentially proximate to the exterior of the dielectric conduit, generates non-thermal plasma from the ionized gas. The non-thermal plasma is discharged from the dielectric conduit and contacts a biological substrate. The non-thermal plasma discharge may be suitable for tissue bonding and sterilization applications.

    Abstract translation: 公开了一种用于接触生物底物的装置和方法。 非热等离子体装置使用电介质导管，点火器电极和RF电极来传送非热等离子体放电。 电介质导管使气体通过其流体连通，并且点火器电极使至少一部分气体电离。 沿电介质导管的外部周向设置的RF电极从电离气体产生非热等离子体。 非热等离子体从电介质导管排出并与生物基板接触。 非热等离子体放电可适用于组织粘合和灭菌应用。

    METHODS AND DEVICES FOR TREATING SURFACES WITH SURFACE PLASMA
    2.
    发明申请
    METHODS AND DEVICES FOR TREATING SURFACES WITH SURFACE PLASMA 审中-公开
    用表面等离子体处理表面的方法和装置

    公开(公告)号：US20140314621A1

    公开(公告)日：2014-10-23

    申请号：US14322131

    申请日：2014-07-02

    Applicant: DREXEL UNIVERSITY

    Inventor： GREGORY FRIDMAN ,  ALEXANDER FRIDMAN ,  ALEXANDER F. GUTSOL ,  GENNADY FRIEDMAN

    IPC: A61L2/03

    CPC classification number: A61L2/03 ,  A61L2/14 ,  A61L2202/24

    Abstract: Methods and devices for treating surfaces of objects using a non-thermal plasma are disclosed herein. The non-thermal plasma is generated through the use of an apparatus configured to generate a non-thermal plasma on its surface. The apparatus is comprised of a substrate that contains one or more electrodes of different polarity. The electrodes are placed within a layer of the substrate acting as a dielectric layer. The apparatus may also have additional layers to contain the dielectric layer. When an appropriate potential, being either an alternating current or pulsed high voltage potential, is applied and removed from the one or more electrodes, the gas on at least one surface of the apparatus becomes ionized and forms a non-thermal plasma. The electrodes can be configured to be of various shapes and sizes to modify or tune the plasma.

    Abstract translation: 本文公开了使用非热等离子体处理物体表面的方法和装置。 通过使用被配置为在其表面上产生非热等离子体的装置来产生非热等离子体。 该装置由含有一个或多个不同极性的电极的基板组成。 电极被放置在用作电介质层的衬底的层内。 该装置还可以具有附加层以容纳电介质层。 当从一个或多个电极施加或移除作为交流或脉冲高电压电位的适当电位时，装置的至少一个表面上的气体被离子化并形成非热等离子体。 电极可以被配置为具有各种形状和尺寸以修改或调谐等离子体。

    NANO DISCHARGES IN LIQUIDS
    4.
    发明申请
    NANO DISCHARGES IN LIQUIDS 审中-公开
    纳米在液体中的排放

    公开(公告)号：US20150141986A1

    公开(公告)日：2015-05-21

    申请号：US14604918

    申请日：2015-01-26

    Applicant: DREXEL UNIVERSITY

    Inventor： DAVID STAACK ,  ALEXANDER FRIDMAN ,  ALEXANDER F. GUTSOL ,  YURY GOGOTSI ,  GENNADY FRIEDMAN

    IPC: A61B18/04

    CPC classification number: A61B18/042 ,  A61B2018/00125 ,  B82Y15/00 ,  G01N21/67 ,  G01N27/68

    Abstract: The present invention is direct to a nano-probe corona tool and uses thereof A nano-probe corona tool is disclosed having a tip with a diameter in the nano-scale, typically around 100 nm. The nano-probe corona tool is constructed of electrically conductive material. On the other end of the tool, a pulsed voltage source outputs a pulsed voltage to generate a pulsed electrical potential at the tip. The pulsed electrical potential at the tip causes a plasma discharge corona to occur. Uses of the corona discharge include, but are not limited to, optical emission spectroscopy, in the enhancement of deposition of coatings and nanoscale welding, e.g., nanotube or nanowires to a contact pad and welding two nanowires together, and in nanoscale surgery. For example, a nano-probe comprising CNTs may be inserted into cell membranes. The resulting corona discharge may be used to destroy tumors within the cell.

    Abstract translation: 本发明直接涉及纳米探针电晕工具及其用途本发明公开了一种纳米级探针电晕工具，其具有直径在纳米级的尖端，通常为约100nm。 纳米探针电晕工具由导电材料构成。 在工具的另一端，脉冲电压源输出脉冲电压以在尖端产生脉冲电位。 尖端处的脉冲电位导致发生等离子体放电电晕。 电晕放电的使用包括但不限于光学发射光谱法，用于增强涂层的沉积和纳米尺度焊接，例如纳米管或纳米线到接触焊盘，并将两个纳米线焊接在一起，以及在纳米级手术中。 例如，可以将包含CNT的纳米探针插入细胞膜。 所产生的电晕放电可用于破坏细胞内的肿瘤。

    Tubular Floating Electrode Dielectric Barrier Discharge For Applications In Sterilization and Tissue Bonding
    5.
    发明申请
    Tubular Floating Electrode Dielectric Barrier Discharge For Applications In Sterilization and Tissue Bonding 审中-公开
    管状浮动电极介质阻挡放电用于灭菌和组织接合

    公开(公告)号：US20160193373A1

    公开(公告)日：2016-07-07

    申请号：US15067715

    申请日：2016-03-11

    Applicant: DREXEL UNIVERSITY

    Inventor： GREGORY FRIDMAN ,  ALEXANDER FRIDMAN ,  ALEXANDER F. GUTSOL ,  GENNADY FRIEDMAN ,  DAVID STAACK

    IPC: A61L2/14 ,  H05H1/24 ,  A61L2/00

    CPC classification number: A61L2/14 ,  A61L2/0011 ,  B01J19/087 ,  H05H1/2406 ,  H05H2001/245 ,  H05H2001/2456 ,  H05H2245/122

    Abstract: Disclosed is a device and method for contacting a biological substrate. A non-thermal plasma device delivers a non-thermal plasma discharge using a dielectric conduit, an igniter electrode and a RF electrode. The dielectric conduit fluidicly communicates a gas therethrough and an igniter electrode ionizes at least a portion of the gas. The RF electrode, disposed circumferentially proximate to the exterior of the dielectric conduit, generates non-thermal plasma from the ionized gas. The non-thermal plasma is discharged from the dielectric conduit and contacts a biological substrate. The non-thermal plasma discharge may be suitable for tissue bonding and sterilization applications.

    Abstract translation: 公开了一种用于接触生物底物的装置和方法。 非热等离子体装置使用电介质导管，点火器电极和RF电极来传送非热等离子体放电。 电介质导管使气体通过其流体连通，并且点火器电极使至少一部分气体电离。 沿电介质导管的外部周向设置的RF电极从电离气体产生非热等离子体。 非热等离子体从电介质导管排出并与生物基板接触。 非热等离子体放电可适用于组织粘合和灭菌应用。

    METHODS FOR NON-THERMAL APPLICATIONS OF GAS PLASMA TO LIVING TISSUE
    6.
    发明申请
    METHODS FOR NON-THERMAL APPLICATIONS OF GAS PLASMA TO LIVING TISSUE 有权
    气体等离子体生物组织非热应用的方法

    公开(公告)号：US20130310731A1

    公开(公告)日：2013-11-21

    申请号：US13950614

    申请日：2013-07-25

    Applicant: DREXEL UNIVERSITY

    Inventor： ALEXANDER F. GUTSOL ,  ALEXANDER FRIDMAN ,  GENNADY FRIEDMAN ,  GREGORY FRIDMAN

    IPC: A61B18/04

    CPC classification number: A61B18/042 ,  A61N1/40 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2240/20 ,  H05H2245/122

    Abstract: Method for the non-thermal treatment of human or animal tissue with high-voltage electrical discharge plasma is disclosed. The disclosed method employs current through plasma and through tissue not for the purpose of heating the tissue, but instead to maintain the plasma proximate to the tissue being treated. Also disclosed is a method of limiting the current through plasma and through tissue to minimize tissue heating by placement of an insulator or semiconductor between an electrode and tissue resulting in generation of a high-voltage discharge similar to a dielectric barrier discharge. The disclosed non-thermal plasma treatment can be employed to promote coagulation of blood, sterilization, disinfection, re-connection of tissue, and treatment of tissue disorders without causing significant thermal tissue damage.

    Abstract translation: 公开了用高压放电等离子体对人体或动物组织进行非热处理的方法。 所公开的方法采用电流通过等离子体和通过组织而不是用于加热组织的目的，而是将血浆保持在靠近待治疗组织的位置。 还公开了一种限制通过等离子体和通过组织的电流的方法，以通过在电极和组织之间放置绝缘体或半导体来最小化组织加热，导致产生类似于电介质阻挡放电的高压放电。 所公开的非热等离子体处理可用于促进血液凝结，消毒，消毒，组织再连接，以及治疗组织疾病而不引起明显的热组织损伤。

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