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公开(公告)号：US11306054B2
公开(公告)日：2022-04-19
申请号：US16770730
申请日：2018-12-11
Applicant: DSM IP ASSETS B.V.
Inventor： Christine Mendrok-Edinger , Peter Riebel , Angela Wildermann
Abstract: The present invention relates to propanediol monoacetate mononitrate as well as the use thereof as antimicrobial agent, in particular for cosmetic applications.
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Patent Agency Ranking
公开(公告)号：US20140378695A1
公开(公告)日：2014-12-25
申请号：US14377095
申请日：2013-02-11
Applicant: DSM IP ASSETS B.V.
Inventor： Angela Wildermann , Werner Bonrath , Raphael Beumer , Silke Dorn
IPC: C07C253/10 , C07C253/34 , C07C253/30
CPC classification number: C07C253/10 , C07C253/30 , C07C253/34 , C07C255/07
Abstract: The present invention is directed to a process for the manufacture of methyl limonitrile comprising a mixture of 3,7-dimethyl-2,6-nonadiene nitrile, 3,7-dimethyl-3,6-nonadiene nitrile and 7-methyl-3-methylene-6-nonene nitrile comprising the following steps: a) reacting 6-methyl-5-octen-2-one with cyano acetic acid and removing carbon dioxide and water, wherein the reaction and the removal of carbon dioxide and water are performed in the presence of a base and a co-base 1 in an organic solvent, and wherein the organic solvent is a solvent which forms a heteroazeotrop with water; b) removing the solvent and the base of the reaction mixture obtained after having performed step a) or step c) by distillation to obtain a reaction mixture, whereby this step may optionally be performed in the presence of a co-base 2; c) isomerizing the reaction mixture obtained after having performed step a) or step b) to obtain an isomerized reaction mixture in the presence of a co-base 2; whereby step b) can be performed before or after step c).
Abstract translation: 本发明涉及一种制备甲基有限公司的方法，该方法包括3,7-二甲基-2,6-壬二烯腈，3,7-二甲基-3,6-壬二烯腈和7-甲基-3- 亚甲基-6-壬烯腈包括以下步骤：a）使6-甲基-5-辛烯-2-酮与氰基乙酸反应并除去二氧化碳和水，其中二氧化碳和水的反应和除去在 在有机溶剂中存在碱和共碱1，其中有机溶剂是与水形成杂合性的溶剂; b）通过蒸馏除去在进行步骤a）或步骤c）之后获得的反应混合物的溶剂和碱，得到反应混合物，由此该步骤可任选地在共碱2存在下进行; c）使在步骤a）或步骤b）中获得的反应混合物异构化，以在共碱2存在下得到异构化反应混合物; 由此步骤b）可以在步骤c）之前或之后进行。
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公开(公告)号：US09458096B2
公开(公告)日：2016-10-04
申请号：US14377095
申请日：2013-02-11
Applicant: DSM IP ASSETS B.V.
Inventor： Angela Wildermann , Werner Bonrath , Raphael Beumer , Silke Dorn
IPC: C07C253/30 , C07C255/07 , C11D3/50 , C07C253/10 , C07C253/34
CPC classification number: C07C253/10 , C07C253/30 , C07C253/34 , C07C255/07
Abstract: The present invention is directed to a process for the manufacture of methyl limonitrile comprising a mixture of 3,7-dimethyl-2,6-nonadiene nitrile, 3,7-dimethyl-3,6-nonadiene nitrile and 7-methyl-3-methylene-6-nonene nitrile comprising the following steps: a) reacting 6-methyl-5-octen-2-one with cyano acetic acid and removing carbon dioxide and water, wherein the reaction and the removal of carbon dioxide and water are performed in the presence of a base and a co-base 1 in an organic solvent, and wherein the organic solvent is a solvent which forms a heteroazeotrop with water; b) removing the solvent and the base of the reaction mixture obtained after having performed step a) or step c) by distillation to obtain a reaction mixture, whereby this step may optionally be performed in the presence of a co-base 2; c) isomerizing the reaction mixture obtained after having performed step a) or step b) to obtain an isomerized reaction mixture in the presence of a co-base 2; whereby step b) can be performed before or after step c).
Abstract translation: 本发明涉及一种制备甲基有限公司的方法，该方法包括3,7-二甲基-2,6-壬二烯腈，3,7-二甲基-3,6-壬二烯腈和7-甲基-3- 亚甲基-6-壬烯腈包括以下步骤：a）使6-甲基-5-辛烯-2-酮与氰基乙酸反应并除去二氧化碳和水，其中二氧化碳和水的反应和除去在 在有机溶剂中存在碱和共碱1，其中有机溶剂是与水形成杂合性的溶剂; b）通过蒸馏除去在进行步骤a）或步骤c）之后获得的反应混合物的溶剂和碱，得到反应混合物，由此该步骤可任选地在共碱2存在下进行; c）使在步骤a）或步骤b）中获得的反应混合物异构化，以在共碱2存在下得到异构化反应混合物; 由此步骤b）可以在步骤c）之前或之后进行。
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4.发明授权Nitrogen monoxide as cis/trans isomerization catalysts for unsaturated compounds 有权一氧化碳作为不饱和化合物的顺式/反式异构化催化剂公开(公告)号：US09434671B2
公开(公告)日：2016-09-06
申请号：US14652286
申请日：2013-12-18
Applicant: DSM IP ASSETS B.V.
Inventor： René Tobias Stemmler , Nadine Greiner , Angela Wildermann
IPC: C07C45/67 , C07C29/56 , C07C33/02 , C07C43/313 , C07C49/203
CPC classification number: C07C43/313 , C07B2200/09 , C07C29/56 , C07C33/02 , C07C45/67 , C07C49/203
Abstract: The present invention relates to a process of a cis/trans isomerization of an unsaturated compound A being selected from the group consisting of unsaturated ketones, unsaturated ketals, unsaturated aldehydes, unsaturated acetals, unsaturated carboxylic acids, esters of an unsaturated carboxylic acid and amides of an unsaturated carboxylic acid using nitrogen monoxide as cis/trans isomerization catalyst. It has been observed that the isomerization is very efficient and fast.
Abstract translation: 本发明涉及不饱和化合物A的顺式/反式异构化方法，其选自不饱和酮，不饱和缩酮，不饱和醛，不饱和缩醛，不饱和羧酸，不饱和羧酸的酯和酰胺的酰胺 使用一氧化氮作为顺式/反式异构化催化剂的不饱和羧酸。 已经观察到异构化非常有效和快速。
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公开(公告)号：US09340750B2
公开(公告)日：2016-05-17
申请号：US14378551
申请日：2013-02-11
Applicant: DSM IP ASSETS B.V.
Inventor： Raphael Beumer , Werner Bonrath , Silke Dorn , Angela Wildermann
IPC: C11B9/00 , C07C253/30
CPC classification number: C11B9/0023 , C07C253/30 , C07C255/07
Abstract: The present invention is directed to a process for the manufacture of methyl limonitrile comprising a mixture of 3,7-dimethyl-2,6-nonadiene nitrile, 3,7-dimethyl-3,6-nonadiene nitrile and 7-methyl-3-methylene-6-nonene nitrile comprising the following steps: a) reacting 6-methyl-5-octen-2-one with cyano acetic acid and removing carbon dioxide and water, wherein the reaction and the removal of carbon dioxide and water are performed in the presence of a base and a co-base in an organic solvent, wherein the base is pyridine, wherein the co-base is 1,4-diamino butane, and wherein the organic solvent is a solvent which forms a heteroazeotrop with water; b) removing the solvent and pyridine of the reaction mixture obtained after having performed step a) or step c) by distillation to obtain a reaction mixture; c) isomerizing the reaction mixture obtained after having performed step a) or step b) to obtain an isomerized reaction mixture; whereby step b) can be performed before or after step c).
Abstract translation: 本发明涉及一种制备甲基有限公司的方法，该方法包括3,7-二甲基-2,6-壬二烯腈，3,7-二甲基-3,6-壬二烯腈和7-甲基-3- 亚甲基-6-壬烯腈包括以下步骤：a）使6-甲基-5-辛烯-2-酮与氰基乙酸反应并除去二氧化碳和水，其中二氧化碳和水的反应和除去在 在有机溶剂中存在碱和共碱，其中所述碱为吡啶，其中所述共碱为1,4-二氨基丁烷，并且其中所述有机溶剂是与水形成杂合性的溶剂; b）在通过蒸馏进行步骤a）或步骤c）之后，除去反应混合物中的溶剂和吡啶，得到反应混合物; c）使进行步骤a）或步骤b）后得到的反应混合物异构化得到异构化反应混合物; 由此步骤b）可以在步骤c）之前或之后进行。
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公开(公告)号：US20150031597A1
公开(公告)日：2015-01-29
申请号：US14378551
申请日：2013-02-11
Applicant: DSM IP ASSETS B.V.
Inventor： Raphael Beumer , Werner Bonrath , Silke Dorn , Angela Wildermann
IPC: C11B9/00
CPC classification number: C11B9/0023 , C07C253/30 , C07C255/07
Abstract: The present invention is directed to a process for the manufacture of methyl limonitrile comprising a mixture of 3,7-dimethyl-2,6-nonadiene nitrile, 3,7-dimethyl-3,6-nonadiene nitrile and 7-methyl-3-methylene-6-nonene nitrile comprising the following steps: a) reacting 6-methyl-5-octen-2-one with cyano acetic acid and removing carbon dioxide and water, wherein the reaction and the removal of carbon dioxide and water are performed in the presence of a base and a co-base in an organic solvent, wherein the base is pyridine, wherein the co-base is 1,4-diamino butane, and wherein the organic solvent is a solvent which forms a heteroazeotrop with water; b) removing the solvent and pyridine of the reaction mixture obtained after having performed step a) or step c) by distillation to obtain a reaction mixture; c) isomerizing the reaction mixture obtained after having performed step a) or step b) to obtain an isomerized reaction mixture; whereby step b) can be performed before or after step c).
Abstract translation: 本发明涉及一种制备甲基有限公司的方法，该方法包括3,7-二甲基-2,6-壬二烯腈，3,7-二甲基-3,6-壬二烯腈和7-甲基-3- 亚甲基-6-壬烯腈包括以下步骤：a）使6-甲基-5-辛烯-2-酮与氰基乙酸反应并除去二氧化碳和水，其中二氧化碳和水的反应和除去在 在有机溶剂中存在碱和共碱，其中所述碱为吡啶，其中所述共碱为1,4-二氨基丁烷，并且其中所述有机溶剂是与水形成杂合性的溶剂; b）在通过蒸馏进行步骤a）或步骤c）之后，除去反应混合物中的溶剂和吡啶，得到反应混合物; c）使进行步骤a）或步骤b）后得到的反应混合物异构化得到异构化反应混合物; 由此步骤b）可以在步骤c）之前或之后进行。
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