公开(公告)号：US20190077736A1

公开(公告)日：2019-03-14

申请号：US16084285

申请日：2017-03-14

申请人： BASF SE

发明人： Martine DEHN ,  Bernhard BRUNNER ,  Klaus EBEL ,  Sabine HUBER

IPC分类号： C07C29/56 ,  C07C45/38 ,  B01J23/44 ,  B01J23/52 ,  B01J21/04 ,  B01J21/08

CPC分类号： C07C29/56 ,  B01J21/04 ,  B01J21/08 ,  B01J23/44 ,  B01J23/52 ,  C07C33/03 ,  C07C45/38 ,  C07C47/21

摘要： The present invention relates to a process for preparing 3-methyl-2-butenol (prenol) and 3-methyl-2-butenal (prenal) from 3-methyl-3-butenol (isoprenol), in which 3-methyl-3-butenol is subjected to a catalytic isomerization over a carbon-supported Pd catalyst in the presence of a gas mixture comprising 1% to 15% by volume of oxygen to obtain a first product mixture, and the first product mixture is subjected to an oxidative dehydrogenation over a Pd catalyst comprising SiO2 and/or Al2O3 as support material, or over a carbon-supported Pd/Au catalyst in the presence of a gas mixture comprising 5% to 25% by volume of oxygen.

公开(公告)号：US09975837B2

公开(公告)日：2018-05-22

申请号：US15536524

申请日：2015-12-18

申请人： BASF SE

发明人： Mathias Schelwies ,  Rocco Paciello ,  Gunnar Heydrich ,  Günter Wegner ,  Gerd-Dieter Tebben ,  Martin Haubner ,  Andreas Keller ,  Oliver Bey ,  Stephanie Renz ,  Georg Seeber

IPC分类号： C07C45/62 ,  C07C29/56 ,  C07C29/17

CPC分类号： C07C45/62 ,  C07B2200/07 ,  C07C29/172 ,  C07C29/56 ,  C07C2601/14 ,  C07C47/21 ,  C07C47/02 ,  C07C35/12 ,  C07C35/17

摘要： The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I): in which R1, R2: are identical or different and are C6- to C10-aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino; Z is a group CHR3R4 or aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino, wherein R3 and R4 are as defined in the claims and the description.

公开(公告)号：US20150274763A1

公开(公告)日：2015-10-01

申请号：US14730623

申请日：2015-06-04

申请人： Apeiron Sythesis S.A.

发明人： Krzysztof Skowerski ,  Lukasz Gulajski ,  Michal Bieniek ,  Stefan Czarnocki ,  Grzegorz Szczpaniak ,  Celina Wierzbicka

IPC分类号： C07F15/00 ,  B01J31/22

CPC分类号： C07F15/0046 ,  B01J31/2204 ,  B01J31/2273 ,  B01J31/2278 ,  B01J31/2295 ,  B01J2231/543 ,  B01J2531/821 ,  B01J2531/825 ,  B01J2531/96 ,  B01J2540/42 ,  B01J2540/64 ,  C07B2200/09 ,  C07C29/32 ,  C07C29/56 ,  C07C67/333 ,  C07C209/68 ,  C07C2601/10 ,  C07D307/28 ,  C08G61/08 ,  C08G2261/3324 ,  C08G2261/418 ,  C07C211/63 ,  C07C69/74 ,  C07C33/035

摘要： Disclosed herein is a general method for the preparation of complexes containing a quaternary onium group in an inert ligand. Some of these complexes may be represented by formula 1: Methods for the preparation of complexes of formula 1, the preparation of intermediates and the use of complexes of formula 1 in metathesis reactions and a method for conducting an olefin metathesis reaction are also described.

摘要翻译： 本文公开了在惰性配体中制备含有季鎓基团的络合物的一般方法。 这些配合物中的一些可以由式1表示：还描述了制备式1的络合物的方法，中间体的制备和式1的络合物在复分解反应中的用途和用于进行烯烃复分解反应的方法。

公开(公告)号：US08692025B2

公开(公告)日：2014-04-08

申请号：US13503515

申请日：2010-10-14

申请人： Andreas Lanver ,  Klaus Ebel ,  Karl Beck ,  Ralf Pelzer ,  Jörg Botzem ,  Ulrich Griesbach

发明人： Andreas Lanver ,  Klaus Ebel ,  Karl Beck ,  Ralf Pelzer ,  Jörg Botzem ,  Ulrich Griesbach

IPC分类号： C07C45/29 ,  C07C29/32

CPC分类号： C07C29/32 ,  C07C29/56 ,  C07C45/29 ,  C07C33/20 ,  C07C47/228

摘要： The invention relates to a process for the preparation of m- or p-substituted phenylalkanols of the formula (I) in which R1 is bonded to the phenyl ring in the m- or p-position and is C1-C5-alkyl, and R2, R3, R4 and R5, independently of one another, are hydrogen or methyl, wherein an unsubstituted phenylalkanol of the formula (II) in which R2, R3, R4 and R5 have the meanings given under formula (I) is alkylated together with a C1-C5-alkyl halide of the formula (III) R1-Hal  (III), in which R1 has the meaning given under formula (I) and Hal is halogen, in the presence of a Friedel-Crafts catalyst to give an m- or p-alkyl-substituted phenylalkanol of the formula (I), then the reaction mixture is worked-up and the desired m- or p-alkyl-substituted phenylalkanol of the formula (I) is separated off, the other formed by-products are returned to the reaction mixture and these are isomerized in the presence of a Friedel-Crafts catalyst to give the desired m- or p-alkyl-substituted phenylalkanol. From the m- or p-alkyl-substituted phenylalkanols of the formula (I), it is possible to form, by oxidation or dehydrogenation, as products of value, the corresponding aldehydes, which play an interesting role as fragrances and aroma chemicals.

摘要翻译： 本发明涉及一种制备式（I）的间 - 或对 - 取代的苯烷醇的方法，其中R 1与m-或p-位上的苯环键合并且是C1-C5-烷基，R2 R 3，R 4和R 5彼此独立地为氢或甲基，其中R 2，R 3，R 4和R 5具有式（I）所示含义的式（II）的未取代的苯基烷醇与 其中R 1具有式（I）所示含义，Hal为卤素的式（III）R1-Hal（Ⅲ）的C1-C5烷基卤化物，在Friedel-Crafts催化剂存在下，得到m- 或式（I）的对烷基取代的苯基链烷醇，然后将反应混合物处理并分离所需的式（I）的间 - 或对 - 烷基取代的苯基烷醇，另一个形成的副产物 返回到反应混合物中，并将它们在Friedel-Crafts催化剂存在下异构化，得到所需的间 - 或对 - 烷基取代的苯基 kanol 从式（I）的间 - 或对 - 烷基取代的苯烷醇，可以通过氧化或脱氢形成作为有价值的产物，相应的醛作为香料和香气化学品起着重要的作用。

公开(公告)号：US08536341B2

公开(公告)日：2013-09-17

申请号：US12526860

申请日：2008-02-15

申请人： Werner Bonrath ,  Jean-Francois Eckhard ,  Manfred L. Eggersdorfer ,  Ramona Hinze ,  Wolfgang F. Hölderich ,  Michael H. Valkenberg

发明人： Werner Bonrath ,  Jean-Francois Eckhard ,  Manfred L. Eggersdorfer ,  Ramona Hinze ,  Wolfgang F. Hölderich ,  Michael H. Valkenberg

IPC分类号： C07D211/94 ,  C07C29/56

CPC分类号： C07C29/56 ,  C07C33/02

摘要： The invention relates to a process of reacting a primary allylic alcohol with a compound containing a) a metal selected from the group consisting of Ag, Au, Ce, Mn, Ni, Ru, Re, Zn and Co preferably Ag and b) an oxidant like TEMPO (2,2′,6,6′-tetra-methylpiperidin-1-oxyl) or its derivates and c) a co-oxidants selected from the group of peroxodisulfates (PDS), H2SO5, H2O2, NaOCl, O2, KOCl, and air.

摘要翻译： 本发明涉及使一级烯丙基醇与含有a）选自Ag，Au，Ce，Mn，Ni，Ru，Re，Zn和Co的金属优选Ag和b）氧化剂 例如TEMPO（2,2'，6,6'-四甲基哌啶-1-氧基）或其衍生物，和c）选自过氧二硫酸盐（PDS），H 2 SO 5，H 2 O 2，NaOCl，O 2，KOCl的共氧化剂 ，和空气。

公开(公告)号：US20130225807A1

公开(公告)日：2013-08-29

申请号：US13779602

申请日：2013-02-27

申请人： Apeiron Synthesis Sp. zo.o.

发明人： Krzysztof Skowerski ,  Lukasz Gulajski ,  Michal Bieniek

IPC分类号： B01J31/22

CPC分类号： C07F15/0046 ,  B01J31/2204 ,  B01J31/2273 ,  B01J31/2278 ,  B01J31/2295 ,  B01J2231/543 ,  B01J2531/821 ,  B01J2531/825 ,  B01J2531/96 ,  B01J2540/42 ,  B01J2540/64 ,  C07B2200/09 ,  C07C29/32 ,  C07C29/56 ,  C07C67/333 ,  C07C209/68 ,  C07C2601/10 ,  C07D307/28 ,  C08G61/08 ,  C08G2261/3324 ,  C08G2261/418 ,  C07C211/63 ,  C07C69/74 ,  C07C33/035

摘要： Disclosed herein is a general method for the preparation of complexes containing a quaternary onium group in an inert ligand. Some of these complexes may be represented by formula 1: Methods for the preparation of complexes of formula 1, the preparation of intermediates and the use of complexes of formula 1 in metathesis reactions and a method for conducting an olefin metathesis reaction are also described.

公开(公告)号：US20130210904A1

公开(公告)日：2013-08-15

申请号：US13586687

申请日：2012-08-15

申请人： Jeremy E. Wulff ,  Michael G. Brant ,  Jeremy W. Mason ,  Caleb M. Bromba ,  Martin J. Boulanger

发明人： Jeremy E. Wulff ,  Michael G. Brant ,  Jeremy W. Mason ,  Caleb M. Bromba ,  Martin J. Boulanger

IPC分类号： C07C279/16 ,  C07C215/44 ,  C07C211/41 ,  C07D333/78 ,  C07C35/31

CPC分类号： C07C279/16 ,  C07C29/56 ,  C07C35/31 ,  C07C67/08 ,  C07C67/29 ,  C07C211/41 ,  C07C215/44 ,  C07C233/52 ,  C07C279/22 ,  C07C2602/22 ,  C07D333/78 ,  C07C69/145 ,  C07C69/16

摘要： Disclosed embodiments concern the synthesis and use of therapeutic compounds that for treating emerging flu strains and minimizing resistance to such strains. Methods for making the disclosed compounds concern using a base-mediated addition/cyclization sequence followed by functional group manipulation to develop functionalized compounds that can target neuraminidase, which makes them ideal candidates for treating influenza. Pharmaceutical compositions comprising the therapeutic compounds and biologically-acceptable materials are also described. Methods of inhibiting neuraminidase in subjects that are suspected of containing neuraminidase are also described. The use of metabolites of the disclosed compounds can also be used in diagnostic assays for therapeutic dosing of the disclosed compounds.

摘要翻译： 公开的实施方案涉及用于治疗新出现的流感病毒株并最小化对这些菌株的抗性的治疗化合物的合成和用途。 制备所公开的化合物的方法涉及使用碱介导的加成/环化顺序，随后进行官能团操作以开发可靶向神经氨酸酶的官能化化合物，这使其成为治疗流感的理想候选物。 还描述了包含治疗化合物和生物学上可接受的材料的药物组合物。 还描述了怀疑含有神经氨酸酶的受试者中抑制神经氨酸酶的方法。 所公开化合物的代谢物的使用也可用于所公开化合物的治疗剂量的诊断测定。

公开(公告)号：US20110257412A1

公开(公告)日：2011-10-20

申请号：US13140356

申请日：2009-12-17

申请人： Hisanori Itoh ,  Yoji Hori

发明人： Hisanori Itoh ,  Yoji Hori

IPC分类号： C07C29/141 ,  C07F5/06

CPC分类号： C07F5/069 ,  C07B2200/07 ,  C07C29/56 ,  C07C2601/14 ,  C07C35/17

摘要： To provide a process for increasing the proportion of an optical isomer of not only a compound having a closed ring but also a compound not having a closed ring when an optical isomer mixture of a compound having both a formyl group and a double bond capable of causing a carbonyl-ene ring closing reaction in the same molecule is subjected to a ring closing reaction. A process for increasing the proportion of an optical isomer characterized by subjecting an optical isomer mixture of a compound having both a formyl group and a double bond capable of causing a carbonyl-ene ring closing reaction in the same molecule to a ring closing reaction in the presence of a predetermined aluminum complex represented by the general formula: [Al2(L1)n(L2)3-n]m.

摘要翻译： 为了提供不仅具有封闭环的化合物的光学异构体的比例而且当具有甲酰基和双键的化合物的光学异构体混合物能够引起 在相同分子中的羰基 - 烯环闭合反应进行闭环反应。 一种增加光学异构体比例的方法，其特征在于使具有能够在同一分子中引起羰基 - 烯环闭合反应的甲酰基和双键的化合物的旋光异构体混合物在 由通式[Al2（L1）n（L2）3-n] m表示的预定铝络合物的存在。

公开(公告)号：US07709688B2

公开(公告)日：2010-05-04

申请号：US11720279

申请日：2005-11-24

申请人： Eike Johannes Bergner ,  Klaus Ebel ,  Thorsten Johann ,  Oliver Löber

发明人： Eike Johannes Bergner ,  Klaus Ebel ,  Thorsten Johann ,  Oliver Löber

IPC分类号： C07C29/17 ,  C07C35/12

CPC分类号： C07C29/17 ,  C07B2200/07 ,  C07C29/172 ,  C07C45/002 ,  C07C2601/14 ,  C12C11/02 ,  C07C33/025 ,  C07C35/12 ,  C07C29/56 ,  C07C35/17 ,  C07C47/21

摘要： Processes comprising: (a) enantioselectively hydrogenating a staffing material comprising a component selected from geraniol, nerol and mixtures thereof to form optically active citronellol; (b) converting the optically active citronellol to optically active citronellal; (c) cyclizing the optically active citronellal to form a mixture comprising optically active isopulegol; and (d) subjecting the mixture to further processing comprising: (i) separating the optically active isopulegol from the mixture and hydrogenating the separated optically active isopulegol to form optically active menthol; or (ii) hydrogenating the optically active isopulegol in the mixture to form optically active menthol and separating the optically active menthol from the mixture.

摘要翻译： 方法包括：（a）对对选择性氢化包含选自香叶醇，橙花醇及其混合物的组分的起始材料以形成光学活性香茅醇; （b）将光学活性香茅醇转化为光学活性香茅醛; （c）使光学活性香茅醛环化以形成包含光学活性异ule ol醇的混合物; 和（d）对所述混合物进行进一步处理，包括：（i）从混合物中分离光学活性异胡胶，并将分离的光学活性异胡醇氢化以形成光学活性薄荷醇; 或者（ⅱ）将混合物中的光学活性异ule）醇氢化以形成光学活性薄荷醇，并将该光学活性薄荷醇与混合物分离。

公开(公告)号：US20090143585A1

公开(公告)日：2009-06-04

申请号：US12067790

申请日：2006-09-21

申请人： Douglas Grotjahn

发明人： Douglas Grotjahn

IPC分类号： C07C29/56 ,  C07F15/00

CPC分类号： C07C45/512 ,  B01J31/189 ,  B01J31/2295 ,  B01J31/2404 ,  B01J2231/52 ,  B01J2531/821 ,  C07C5/2593 ,  C07C29/56 ,  C07C41/32 ,  C07C2531/24 ,  C07F17/02 ,  C07C11/02 ,  C07C33/025 ,  C07C47/19 ,  C07C47/02 ,  C07C43/15

摘要： The current invention provides novel bifunctional catalysts. The bifunctional catalysts are prepared from phosphine ligands and a cyclopentadienyl metal complex and are useful for forming isomers of hydrocarbon species. The hydrocarbon can be an alkenol having the alkene and alcohol groups far apart and the catalyst will move the double bond across numerous carbon atoms. The hydrocarbon can also be an achiral alkenol and the catalyst will form a chiral alcohol therefrom. Moreover, deuterated water may be added to the isomerization reaction mixture for forming deuterated hydrocarbon species.

摘要翻译： 本发明提供新的双功能催化剂。 双功能催化剂由膦配体和环戊二烯基金属络合物制备，可用于形成烃类异构体。 烃可以是具有较远的烯烃和醇基的烯醇，并且催化剂将跨越多个碳原子移动双键。 烃也可以是非手性链烯醇，催化剂由此形成手性醇。 此外，可以将氘代水加入用于形成氘化烃物质的异构化反应混合物中。