公开(公告)号：US10561702B2

公开(公告)日：2020-02-18

申请号：US16060096

申请日：2016-12-09

Applicant: DSM IP ASSETS B.V.

Inventor： Remo Campiche ,  Dominik Imfeld ,  Eileen Jackson ,  Eliane Ursula Wandeler

IPC: A61K38/05 ,  A61K8/64 ,  A61Q19/00 ,  A61P17/10 ,  A61P17/08 ,  A61K8/06 ,  A61K8/55 ,  A61K9/107 ,  A61K47/24

Abstract: The present invention relates to a novel use of proline containing dipeptides for the prevention and/or treatment of skin conditions associated with altered, damaged or malfunctioning sebaceous glands.

公开(公告)号：US10179797B2

公开(公告)日：2019-01-15

申请号：US15774649

申请日：2016-11-23

Applicant: DSM IP ASSETS B.V.

Inventor： Stéphanie Boudon ,  Eileen Jackson ,  Rolf Schuetz ,  Jürgen Herbert Vollhardt ,  Peter Wikstroem ,  Eliane Ursula Wandeler

IPC: A61Q19/08 ,  A61Q19/00 ,  A61K31/675 ,  A61K31/662 ,  A61K31/67 ,  C07C53/18 ,  A61K8/55 ,  C07F9/6553 ,  C07F9/30 ,  C07F9/572

Abstract: This invention relates to compounds that are selective inhibitors of Matrix Metalloprotease-12 (MMP-12), to cosmetic and pharmaceutical compositions containing them, and to their use in the prevention and/or treatment of ailments associated with MMP-12. Formula (I).