公开(公告)号：US10059738B2

公开(公告)日：2018-08-28

申请号：US15321792

申请日：2015-06-01

Applicant: DSM IP Assets B.V.

Inventor： Jonathan Alan Medlock ,  Peter Wikstroem

IPC: C07C231/14 ,  C07K5/062 ,  C07K1/02 ,  C07K1/06 ,  C07K1/107 ,  C07K1/10

CPC classification number: C07K5/06069 ,  C07C311/13 ,  C07K1/02 ,  C07K1/061 ,  C07K1/10 ,  C07K1/1075

Abstract: The present invention is related to a novel and improved process for the manufacture of compounds of formula (I) or salts thereof herein designated as benzylsulfonyl-Ser-X-4-amidinobenzylamide, wherein R is a C1 to C6 linear or branched aliphatic hydrocarbon chain optionally substituted with a C6 to C10 aromatic group.

公开(公告)号：US20150208649A1

公开(公告)日：2015-07-30

申请号：US14420778

申请日：2013-08-12

Applicant: DSM IP ASSETS B.V.

Inventor： Christine Mendrok-Edinger ,  Rainer Voegeli ,  Peter Wikstroem

IPC: A01N33/10 ,  A01N43/80 ,  A01N31/14 ,  A01N37/10

CPC classification number: A01N33/10 ,  A01N31/14 ,  A01N33/04 ,  A01N37/10 ,  A01N43/80 ,  A61K8/415 ,  A61K2800/10 ,  A61K2800/524 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/10 ,  A01N37/40

Abstract: The present invention relates to compositions comprising p-hydroxybenzylamine or a salt thereof and at least one preservative as well as to the use of p-hydroxybenzylamine or a salt thereof to boost the antimicrobial activity of at least one preservative.

Abstract translation: 本发明涉及包含对羟基苄基胺或其盐和至少一种防腐剂的组合物，以及使用对羟基苄基胺或其盐来增强至少一种防腐剂的抗微生物活性。

公开(公告)号：US09980889B2

公开(公告)日：2018-05-29

申请号：US15331711

申请日：2016-10-21

Applicant: DSM IP ASSETS B.V.

Inventor： Christine Mendrok-Edinger ,  Rainer Voegeli ,  Peter Wikstroem

IPC: A01N33/04 ,  A01N33/24 ,  A61K8/41 ,  A61K8/89 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q17/00 ,  A61K8/04 ,  A61K8/06 ,  A61Q1/02 ,  A61Q5/00 ,  A61Q19/10

CPC classification number: A61K8/41 ,  A01N33/04 ,  A01N33/24 ,  A61K8/042 ,  A61K8/062 ,  A61K8/064 ,  A61K8/89 ,  A61K2800/52 ,  A61K2800/74 ,  A61Q1/02 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/005 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/10

Abstract: The present invention relates to the use of p-hydroxybenzylamine or a salt thereof as antimicrobial agent as well as to composition comprising said agent.

公开(公告)号：US10179797B2

公开(公告)日：2019-01-15

申请号：US15774649

申请日：2016-11-23

Applicant: DSM IP ASSETS B.V.

Inventor： Stéphanie Boudon ,  Eileen Jackson ,  Rolf Schuetz ,  Jürgen Herbert Vollhardt ,  Peter Wikstroem ,  Eliane Ursula Wandeler

IPC: A61Q19/08 ,  A61Q19/00 ,  A61K31/675 ,  A61K31/662 ,  A61K31/67 ,  C07C53/18 ,  A61K8/55 ,  C07F9/6553 ,  C07F9/30 ,  C07F9/572

Abstract: This invention relates to compounds that are selective inhibitors of Matrix Metalloprotease-12 (MMP-12), to cosmetic and pharmaceutical compositions containing them, and to their use in the prevention and/or treatment of ailments associated with MMP-12. Formula (I).

公开(公告)号：US20150174021A1

公开(公告)日：2015-06-25

申请号：US14414004

申请日：2013-07-08

Applicant: DSM IP ASSETS B.V.

Inventor： Remo Campiche ,  Rainer Voegeli ,  Peter Wikstroem

IPC: A61K8/34 ,  A61Q19/00 ,  A61K8/64 ,  A61Q5/00

CPC classification number: A61K8/345 ,  A61K8/64 ,  A61K2800/5922 ,  A61K2800/782 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/007

Abstract: The present invention relates to the field of active compositions for use in cosmetic products for humans. More particularly, the present invention relates to a cosmetic composition comprising benzylsulfonyl-D-Ser-homoPhe-(4-amidino-benzylamide), or a salt thereof, and a polyalcohol. Moreover, it relates to the use of said composition for maintaining, restoring, and/or improving the skin hydration, and/or the transepidermal water loss level in human skin. The present invention further relates to the use of benzylsulfonyl-D-Ser-homoPhe-(4-amidino-benzylamide), or a salt thereof, in combination with a polyalcohol for the co-inhibition of both plasmin and urokinase activity in the skin and/or the scalp.

Abstract translation: 本发明涉及用于人类化妆品的活性组合物领域。 更具体地，本发明涉及包含苄基磺酰基-D-Ser-高 - （4-脒基 - 苄基酰胺）或其盐和多元醇的化妆品组合物。 此外，它涉及所述组合物在人皮肤中维持，恢复和/或改善皮肤水合和/或经表皮水分损失水平的用途。 本发明还涉及苄基磺酰基-D-Ser-高 - （4-脒基 - 苄基酰胺）或其盐与多元醇的组合在皮肤中共同抑制纤溶酶和尿激酶活性的用途，以及 /或头皮。