公开(公告)号：US20250002873A1

公开(公告)日：2025-01-02

申请号：US18700931

申请日：2022-10-19

Applicant: DSM IP ASSETS B.V.

Inventor： Valmik Kanubhai VYAS ,  Peter Louis HOUSTON ,  Jenna McMAHON ,  René Marcel DE JONG

IPC: C12N9/04 ,  C12P7/22

Abstract: The present invention is related to bio-production of retinoids with improved purity profile, particularly bio-retinoids with a high percentage of retinyl acetate, wherein the flux towards retinol is increased and wherein the percentage of unwanted by-products such as dihydroretinoids or retinal is minimized to a range of below 10% by expressing retinol dehydrogenase (EC 1.1.1.105, RDH22) derived from Yarrowia lipolytica (Candida lipolytica) or Wickerhamomyces anomalus (Hanensula anomala).

公开(公告)号：US20220064607A1

公开(公告)日：2022-03-03

申请号：US17419079

申请日：2019-12-30

Applicant: DSM IP Assets B.V.

Inventor： Peter Louis HOUSTON ,  René Marcel DE JONG ,  Valmik Kanubhai VYAS ,  René VERWAAL ,  Jenna McMAHON ,  Anna SYMBOR-NAGRABSKA

IPC: C12N9/10 ,  C12P7/62 ,  C12N1/18

Abstract: The present invention is related to production of retinyl acetate generated via enzymatic conversion of retinol, said process including the use of modified enzymes with improved activity.