公开(公告)号：US20160346364A1

公开(公告)日：2016-12-01

申请号：US15101630

申请日：2014-12-11

Applicant: DSM IP ASSETS B.V.

Inventor： Maaike Johanna BRUINS ,  Luppo EDENS ,  Lenneke NAN

IPC: A61K38/48 ,  A23L5/20 ,  A23L29/00 ,  A21D8/04 ,  A61K9/00 ,  C12N9/62

CPC classification number: A61K38/488 ,  A21D8/042 ,  A23L5/25 ,  A23L29/06 ,  A23V2002/00 ,  A61K9/0053 ,  A61K38/482 ,  C12C5/004 ,  C12N9/62 ,  C12Y304/21026 ,  C12Y304/23018 ,  C12Y304/23019 ,  A61K2300/00

Abstract: This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and/or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed. It also relates to an enzyme composition comprising the Aspergillus niger aspergilloglutamic peptidase and an additional enzyme, and to foodstuff comprising the Aspergillus niger aspergilloglutamic peptidase.

Abstract translation: 本发明涉及一种药物或膳食补充剂，其包含能够水解植物食物过敏原的黑曲霉曲霉菌肽酶，更具体地，涉及α-淀粉酶/胰蛋白酶抑制剂，从而治疗由于人的先天免疫应答引起的疾病，和/ 或允许延迟所述疾病的发作。 本发明涉及黑曲霉曲霉菌肽酶能够水解存在于小麦和相关谷物中的α-淀粉酶/胰蛋白酶抑制剂的发现，所述抑制剂是先天免疫应答的强诱导剂。 此外，本发明涉及水解α-淀粉酶/胰蛋白酶抑制剂的方法，包括将包含α-淀粉酶/胰蛋白酶抑制剂的食物组合物与黑曲霉曲霉菌肽酶一起孵育，其中所述抑制剂被水解。 它还涉及包含黑曲霉曲霉菌肽酶和另外的酶的酶组合物，以及包含黑曲霉曲霉菌肽酶的食品。