公开(公告)号：US20240033332A1

公开(公告)日：2024-02-01

申请号：US18257143

申请日：2021-12-16

申请人： KYOTO UNIVERSITY

发明人： Jun TAKAHASHI ,  Bumpei SAMATA

IPC分类号： A61K38/47 ,  A61K38/16 ,  A61K38/17 ,  A61P25/00 ,  A61K38/48

CPC分类号： A61K38/47 ,  A61K38/16 ,  C12Y302/01017 ,  A61K38/17 ,  C12Y304/23005 ,  A61P25/00 ,  C12Y304/23 ,  A61K38/488

摘要： Developing an agent for activating a neuron which activates a brain neuron. The agent is suitable for promoting cell transplantation for a neural disease, survival of a transplanted cell, differentiation of the transplanted cell into a neuronal cell, and/or maturation of the neuron. The agent for activating the neuron contains a protein selected from the group consisting of Lysozyme (LYZ), Secreted phosphoprotein 1 (SPP1), Progranulin (PGrn), Cathepsin D (Ctsd), Cathepsin S (Ctss), Apolipoprotein D (Apod), Sparc, CD52, Macrophage expressed gene 1 (MPEG1), C-C motif chemokine ligand 2 (CCL2), Cystatin F (CST7), Ras family small GTPase 2 (RAC2), Serpin family A member 3 (SERPINA3), Anosmin 1 (ANOS1), Kallikrein-related peptidase 6 (KLK6), Alpha-2-macroglobulin (A2M), GM14295, Galectin 3-binding protein (LGALS3BP), Apolipoprotein C1 (APOC1), and orthologs thereof, or an active fragment thereof, or a nucleic acid encoding the protein or active fragment thereof, and an agent for assisting cell transplantation containing the agent.

公开(公告)号：US11701411B2

公开(公告)日：2023-07-18

申请号：US17102290

申请日：2020-11-23

申请人： Codexis, Inc.

发明人： David C. Schriemer ,  Martial Rey

IPC分类号： A61K38/48 ,  C12N9/50 ,  A61P1/14 ,  A61K9/00 ,  A61K45/06

CPC分类号： A61K38/488 ,  A61K9/0053 ,  A61K38/48 ,  A61K45/06 ,  A61P1/14 ,  C12N9/63 ,  C12Y304/23012

摘要： The invention described herein relates to methods and compositions for treatment of one or more symptoms of gluten intolerance and related conditions (e.g., celiac disease and gluten sensitivity) by administration of a pharmaceutical composition comprising one or more Nepenthes enzymes.

公开(公告)号：US09986751B2

公开(公告)日：2018-06-05

申请号：US15102037

申请日：2014-12-11

申请人： DSM IP ASSETS B.V. ,  NOVOZYMES A/S

发明人： Maaike Johanna Bruins ,  Luppo Edens ,  Helena Maria Nan

IPC分类号： A23K20/189 ,  A23K20/174 ,  A23K10/14 ,  A23K20/20 ,  A23K50/75 ,  A23K50/30 ,  A61K38/48

CPC分类号： A23K20/189 ,  A23K10/14 ,  A23K20/174 ,  A23K20/30 ,  A23K50/30 ,  A23K50/75 ,  A61K38/488 ,  C12Y304/23019

摘要： This invention relates to the use of the Aspergillus niger aspergilloglutamic peptidase in a feed composition containing cereals, pulses, oilseeds, and/or tubers to improve animal performance, reduce nitrogen excretion and/or reduce intestinal inflammation. Furthermore, the present invention relates to a feed composition or a feed additive comprising the Aspergillus niger aspergilloglutamic peptidase. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of efficiently hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat, barley and related cereal species, as well as hydrolyzing trypsin inhibitors that are present in pulses, oilseeds, and tubers. Furthermore, the present invention relates to a method of improving animal performance comprising improving feed conversion ratio, and/or improving daily weight gain, and/or reducing intestinal inflammation, and/or reducing nitrogen excretion in an animal fed a feed stuff containing alpha-amylase and/or trypsin inhibitors, comprising orally administering a sufficient amount of the Aspergillus niger aspergilloglutamic peptidase. It also relates to the pretreatment of feedstuff with the Aspergillus niger aspergilloglutamic peptidase.

公开(公告)号：US09932591B2

公开(公告)日：2018-04-03

申请号：US15105925

申请日：2014-12-18

申请人： Kelvin Lee ,  Abraham Lenhoff ,  Kristin Valente ,  Nick Levy ,  Yatin Gokarn

发明人： Kelvin Lee ,  Abraham Lenhoff ,  Kristin Valente ,  Nick Levy ,  Yatin Gokarn

IPC分类号： C12N15/11 ,  C12N15/113 ,  C07K16/00 ,  C12P21/02 ,  C12N9/20 ,  A61K38/17 ,  A61K38/39 ,  A61K38/42 ,  A61K38/44 ,  A61K38/45 ,  A61K38/48 ,  A61K38/52 ,  A61K47/26 ,  C12P21/00

CPC分类号： C12N15/1137 ,  A61K38/1709 ,  A61K38/1741 ,  A61K38/1761 ,  A61K38/1774 ,  A61K38/39 ,  A61K38/42 ,  A61K38/44 ,  A61K38/443 ,  A61K38/45 ,  A61K38/4813 ,  A61K38/482 ,  A61K38/488 ,  A61K38/52 ,  A61K47/26 ,  C07K16/00 ,  C12N9/20 ,  C12N2310/10 ,  C12N2310/14 ,  C12N2310/20 ,  C12P21/005 ,  C12P21/02 ,  C12Y104/03013 ,  C12Y111/01015 ,  C12Y205/01018 ,  C12Y207/04006 ,  C12Y207/11001 ,  C12Y301/01034 ,  C12Y304/16005 ,  C12Y304/21 ,  C12Y304/23005 ,  C12Y502/01008 ,  C12Y503/04001

摘要： The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.

公开(公告)号：US20170348236A1

公开(公告)日：2017-12-07

申请号：US15622816

申请日：2017-06-14

申请人： NRL PHARMA, INC.

发明人： Hidefumi KUWATA

IPC分类号： A61K9/16 ,  A23P10/30 ,  A61K9/20 ,  A61K38/48 ,  A23K40/30 ,  A61K38/28 ,  A61K38/40 ,  B01J2/04

CPC分类号： A61K9/1652 ,  A23K40/30 ,  A23P10/30 ,  A61K9/1617 ,  A61K9/1694 ,  A61K9/2077 ,  A61K38/28 ,  A61K38/40 ,  A61K38/482 ,  A61K38/488 ,  B01J2/04 ,  C12Y304/21 ,  C12Y304/23001

摘要： The present invention has an object providing microparticles having an average particle size of 100 μm or less.The present invention provides microparticles having an average particle size of 100 μm or less and a method for producing thereof. In addition, the present invention provides medicine, food and feedstuff comprising the microparticles having an average particle size of 100 μm or less.

公开(公告)号：US20160346364A1

公开(公告)日：2016-12-01

申请号：US15101630

申请日：2014-12-11

申请人： DSM IP ASSETS B.V.

发明人： Maaike Johanna BRUINS ,  Luppo EDENS ,  Lenneke NAN

IPC分类号： A61K38/48 ,  A23L5/20 ,  A23L29/00 ,  A21D8/04 ,  A61K9/00 ,  C12N9/62

CPC分类号： A61K38/488 ,  A21D8/042 ,  A23L5/25 ,  A23L29/06 ,  A23V2002/00 ,  A61K9/0053 ,  A61K38/482 ,  C12C5/004 ,  C12N9/62 ,  C12Y304/21026 ,  C12Y304/23018 ,  C12Y304/23019 ,  A61K2300/00

摘要： This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and/or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed. It also relates to an enzyme composition comprising the Aspergillus niger aspergilloglutamic peptidase and an additional enzyme, and to foodstuff comprising the Aspergillus niger aspergilloglutamic peptidase.

摘要翻译： 本发明涉及一种药物或膳食补充剂，其包含能够水解植物食物过敏原的黑曲霉曲霉菌肽酶，更具体地，涉及α-淀粉酶/胰蛋白酶抑制剂，从而治疗由于人的先天免疫应答引起的疾病，和/ 或允许延迟所述疾病的发作。 本发明涉及黑曲霉曲霉菌肽酶能够水解存在于小麦和相关谷物中的α-淀粉酶/胰蛋白酶抑制剂的发现，所述抑制剂是先天免疫应答的强诱导剂。 此外，本发明涉及水解α-淀粉酶/胰蛋白酶抑制剂的方法，包括将包含α-淀粉酶/胰蛋白酶抑制剂的食物组合物与黑曲霉曲霉菌肽酶一起孵育，其中所述抑制剂被水解。 它还涉及包含黑曲霉曲霉菌肽酶和另外的酶的酶组合物，以及包含黑曲霉曲霉菌肽酶的食品。

公开(公告)号：US09101623B2

公开(公告)日：2015-08-11

申请号：US13782160

申请日：2013-03-01

申请人： The Brigham and Women's Hospital, Inc.

发明人： Michael Schlossmacher ,  Valerie Cullen ,  Lamya Shihabuddin ,  Seng H. Cheng

IPC分类号： A61K38/47 ,  A61K38/48 ,  A61K38/17 ,  A61K31/436 ,  A61K45/06 ,  A61K31/00 ,  A61K31/047 ,  A61K31/4353 ,  A61K38/13 ,  A61K48/00

CPC分类号： A61K38/4873 ,  A61K31/00 ,  A61K31/047 ,  A61K31/4353 ,  A61K31/436 ,  A61K31/7088 ,  A61K38/13 ,  A61K38/1709 ,  A61K38/47 ,  A61K38/488 ,  A61K45/06 ,  A61K48/005 ,  A61K2300/00 ,  C12Y302/01045 ,  C12Y304/22041 ,  C12Y304/23005

摘要： This invention relates generally to treating synucleinopathies in subjects that are not clinically diagnosed with a lysosomal storage disease, as well as associated methods of making medicaments and screening methods.

摘要翻译： 本发明一般涉及治疗未临床诊断患有溶酶体贮积病的受试者的突触核蛋白病，以及制备药物和筛选方法的相关方法。

公开(公告)号：US20140140980A1

公开(公告)日：2014-05-22

申请号：US13912077

申请日：2013-06-06

申请人： David Schriemer

发明人： David Schriemer

IPC分类号： A61K38/48 ,  A23L1/30

CPC分类号： C12N9/63 ,  A23L29/06 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/488 ,  C12Y304/23012 ,  A23V2200/304 ,  A23V2250/5486

摘要： Provided herein are compositions, foods comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof for modulating gluten intolerance and related conditions, such as celiac disease.

摘要翻译： 本文提供了组合物，包含楝素或其衍生物的食品和使用楝素或其衍生物调节麸质不耐症和相关病症如乳糜泻的方法。

公开(公告)号：US20130085461A1

公开(公告)日：2013-04-04

申请号：US13645150

申请日：2012-10-04

申请人： BIOMEDICAL CONCEPTS LLC ,  DERMAL THERAPY (BARBADOS) INC.

发明人： Donald H. LEAMAN ,  Alan Lorne PERLMUTTER

IPC分类号： B65D25/04 ,  A61K31/7004 ,  A61K38/46 ,  A61M37/00 ,  A61P17/00 ,  A61P31/04 ,  A61P29/00 ,  A61K31/17 ,  A61P17/02

CPC分类号： A61K31/17 ,  A61F7/034 ,  A61K31/167 ,  A61K31/192 ,  A61K31/194 ,  A61K31/7004 ,  A61K38/48 ,  A61K38/488 ,  A61K45/06 ,  A61M35/00 ,  A61K2300/00

摘要： A pre-debriding composition comprises a chaotropic agent, preferably urea, and, preferably, exfoliating and analgesic agents. The pre-debriding composition reduces the collagen denaturation temperature, Tm, at the site of a wound. Use of the composition along with a supply of heat increases the effectiveness of a subsequent enzymatic debriding treatment. A dressing and heating system is also provided for use with the pre-debriding composition. An “instant activated” debriding composition and package is provided comprising a gel composition and a powdered debriding zymogen composition, wherein mixing of the two compositions results in an activated enzymatic debriding composition. 22290368.1

摘要翻译： 预清除组合物包含离液剂，优选尿素，优选去角质和止痛剂。 预清除组合物降低伤口部位的胶原变性温度Tm。 使用组合物与热量供应增加随后的酶清除治疗的有效性。 还提供了与预清洁组合物一起使用的敷料和加热系统。 提供即时活化的清创组合物和包装，其包含凝胶组合物和粉末化的清创酶原组合物，其中两种组合物的混合产生活化的酶清除组合物。 22290368.1

公开(公告)号：US08333961B2

公开(公告)日：2012-12-18

申请号：US11773034

申请日：2007-07-03

申请人： James R. Privitera

发明人： James R. Privitera

IPC分类号： A61K38/54 ,  A61K38/43 ,  A61K38/00 ,  A61K31/00 ,  A61P35/00

CPC分类号： A61K35/413 ,  A61K31/07 ,  A61K31/205 ,  A61K33/30 ,  A61K36/48 ,  A61K38/465 ,  A61K38/47 ,  A61K38/4873 ,  A61K38/488 ,  A61K2300/00

摘要： A liniment composition for reversing or retarding the growth of cancerous skin tumors comprising primarily, pancreatin, pepsin, betaine HCL, emulsified vitamin A, and zinc, pancrelipase, fenugreek, papain, amylase and ox bile extract, with optional trace amounts of other ingredients.

摘要翻译： 用于逆转或延缓癌性皮肤肿瘤生长的搽剂组合物，其主要包括胰酶，胃蛋白酶，甜菜碱HCL，乳化维生素A和锌，胰脂酶，葫芦巴，木瓜蛋白酶，淀粉酶和牛胆汁提取物，以及任选的微量其它成分。