公开(公告)号：US10087430B2

公开(公告)日：2018-10-02

申请号：US15112885

申请日：2015-01-28

Applicant: DSM IP Assets B.V.

Inventor： James George Metz ,  Jerry M. Kuner ,  David Glen McCaskill ,  Mendy Louise Foster

IPC: C12N9/20 ,  C12N9/16 ,  A61K31/202 ,  C07K14/405 ,  C12P7/64 ,  A23L33/115 ,  C07K14/00 ,  C12N15/79

Abstract: Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.

公开(公告)号：US10968437B2

公开(公告)日：2021-04-06

申请号：US16107108

申请日：2018-08-21

Applicant: DSM IP Assets B.V.

Inventor： James George Metz ,  Jerry M. Kuner ,  David Glen McCaskill ,  Mendy Louise Foster

IPC: C07H21/04 ,  C12N9/20 ,  C12N15/82 ,  C12N15/79 ,  C12N9/10 ,  C12N9/16 ,  A61K31/202 ,  C07K14/405 ,  A23L33/115 ,  C12P7/64 ,  C07K14/00 ,  C07K14/195

Abstract: Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.