公开(公告)号：US20190100733A1

公开(公告)日：2019-04-04

申请号：US16107108

申请日：2018-08-21

Applicant: DSM IP Assets B.V.

Inventor： James G. METZ ,  Jerry M. KUNER ,  David Glen MCCASKILL ,  Mendy Louise FOSTER

IPC: C12N9/10 ,  C12P7/64

Abstract: Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.

公开(公告)号：US20220170037A1

公开(公告)日：2022-06-02

申请号：US17669945

申请日：2022-02-11

Applicant: DSM IP Assets B.V. ,  DOW AgroSciences LLC

Inventor： Terence A. WALSH ,  Daniel GACHOTTE ,  Ann Owens MERLO ,  Paul G. ROESSLER ,  James George METZ ,  Scott BEVAN ,  Jerry M. KUNER

IPC: C12N15/82 ,  C12P7/6427

Abstract: The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).

公开(公告)号：US20160348083A1

公开(公告)日：2016-12-01

申请号：US15112885

申请日：2015-01-28

Applicant: DSM IP ASSETS B.V.

Inventor： James George METZ ,  Jerry M. KUNER ,  David Glen MCCASKILL ,  Mendy Louise FOSTER

IPC: C12N9/20 ,  A23L33/115 ,  C12P7/64 ,  C12N15/79 ,  C07K14/00 ,  A61K31/202

CPC classification number: C12N9/20 ,  A23L33/115 ,  A23V2002/00 ,  A61K31/202 ,  C07K14/00 ,  C07K14/405 ,  C12N9/16 ,  C12N15/79 ,  C12P7/6427 ,  C12Y301/01

Abstract: Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.

Abstract translation: 来自PUFA合成酶的多不饱和脂肪酸（PUFA）的生产和积累的因素摘要公开了PUFA合酶系统的新型增强因子蛋白，编码它们的核酸分子，重组核酸分子和包含这种核酸分子的重组宿主细胞 ，包含其的转基因微生物及其制备和使用方法。 还公开了已被遗传修饰以表达用于生产PUFA的PUFA合酶系统的遗传修饰微生物，其中微生物已被修饰以表达PUFA合酶系统的新增强因子蛋白。