公开(公告)号：US11135165B2

公开(公告)日：2021-10-05

申请号：US16604167

申请日：2018-04-12

Applicant: Daewoong Pharmaceutical Co., Ltd. ,  Liaoning Daewoong Pharmaceutical Co., Ltd.

Inventor： Ye Chang ,  Qing Ri Li ,  Sang Ho Seol ,  Tie Li ,  Chao Tong

IPC: A61K9/10 ,  A61K33/08 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38

Abstract: The present invention provides a suspension comprising aluminum hydroxide and magnesium hydroxide and a method of preparing the same. The aqueous suspension composition according to the present invention ensures an excellent sedimentation rate by using a mixed suspending agent with a specific composition, so that insoluble aluminum hydroxide and magnesium hydroxide do not easily settle, do not form a cake, and are easily redispersed. Since the aqueous suspension composition having an excellent sedimentation rate has not only physical stability, but also forms a homogeneous dispersion system, the reproducibility or effectiveness of bioavailability may be ensured. In addition, the aqueous suspension composition according to the present invention provides an excellent texture, and thus patient compliance increases.

公开(公告)号：US20230094404A1

公开(公告)日：2023-03-30

申请号：US17799774

申请日：2021-02-26

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Wol Young Kim ,  Qing Ri Li ,  Deok Ki Eom ,  Hyae Jung Hyun ,  Joon Seok Park

IPC: C07D417/14

Abstract: The present disclosure relates to a method for preparing a heterocyclic amine derivative, and the preparation method according to the present disclosure has an advantage that a heterocyclic amine derivative having a reduced impurity content can be prepared in a high yield.

公开(公告)号：US11661406B2

公开(公告)日：2023-05-30

申请号：US17266844

申请日：2019-08-09

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Qing Ri Li ,  Hee Kyoon Yoon

IPC: C07D307/79

CPC classification number: C07D307/79

Abstract: A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.