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公开(公告)号：US20160304460A1
公开(公告)日：2016-10-20
申请号：US15029638
申请日：2014-10-21
发明人： Joon Seok Park , Youn Jung Yoon , Chang Min Park , Yun Soo Na , Min Jae Cho , Ho Bin Lee , Mi Ryeong Han , Yeon Jung Park , Ji Duck Kim
IPC分类号： C07D213/82 , C07D471/04 , C07D498/08 , C07D417/06 , C07D401/06 , C07D401/12 , C07D401/04
CPC分类号： C07D213/82 , C07D213/63 , C07D401/04 , C07D401/06 , C07D401/12 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/08
摘要： The present invention relates to novel oxodihydropyridinecarbohydrazide derivatives with excellent antifungal activities, an antifungal composition containing the same, and its use for the prevention and treatment of fungal infectious diseases. The oxodihydropyridinecarbohydrazide derivatives of the present invention have excellent antifungal and fungicidal activities, and thus will be useful for the prevention and treatment of various fungal infections by Candida spp., Aspergillus spp., Cryptococcus neoformans and Trichophyton spp., etc. Additionally, the oxodihydropyridinecarbohydrazide derivatives of the present invention, unlike other fungicidal preparations, can be orally administered.
摘要翻译： 本发明涉及具有优异抗真菌活性的新型氧代二氢吡啶碳酰肼衍生物，含有它们的抗真菌组合物及其用于预防和治疗真菌感染性疾病的用途。 本发明的氧代二氢吡啶碳酰肼衍生物具有优异的抗真菌和杀真菌活性，因此可用于预防和治疗念珠菌属，曲霉属（Aspergillus spp。），新隐隐球菌（Cryptococcus neoformans）和毛癣菌属（Trichophyton spp。）等各种真菌感染。另外，氧代二氢吡啶碳酰肼 本发明的衍生物与其它杀真菌剂不同，可以口服给药。
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公开(公告)号：US09617216B2
公开(公告)日：2017-04-11
申请号：US15029638
申请日：2014-10-21
发明人： Joon Seok Park , Youn Jung Yoon , Chang Min Park , Yun Soo Na , Min Jae Cho , Ho Bin Lee , Mi Ryeong Han , Yeon Jung Park , Ji Duck Kim
IPC分类号： C07D213/63 , C07D401/04 , C07D401/06 , C07D401/12 , A61K31/4412 , A61P31/04 , C07D213/82 , C07D417/06 , C07D487/04 , C07D498/08 , C07D471/04
CPC分类号： C07D213/82 , C07D213/63 , C07D401/04 , C07D401/06 , C07D401/12 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/08
摘要： The present invention relates to novel oxodihydropyridinecarbohydrazide derivatives with excellent antifungal activities, an antifungal composition containing the same, and its use for the prevention and treatment of fungal infectious diseases. The oxodihydropyridinecarbohydrazide derivatives of the present invention have excellent antifungal and fungicidal activities, and thus will be useful for the prevention and treatment of various fungal infections by Candida spp., Aspergillus spp., Cryptococcus neoformans and Trichophyton spp., etc. Additionally, the oxodihydropyridinecarbohydrazide derivatives of the present invention, unlike other fungicidal preparations, can be orally administered.
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