公开(公告)号：US20160304460A1

公开(公告)日：2016-10-20

申请号：US15029638

申请日：2014-10-21

Applicant: DAEWOONG PHARMACEUTICAL CO., LTD.

Inventor： Joon Seok Park ,  Youn Jung Yoon ,  Chang Min Park ,  Yun Soo Na ,  Min Jae Cho ,  Ho Bin Lee ,  Mi Ryeong Han ,  Yeon Jung Park ,  Ji Duck Kim

IPC: C07D213/82 ,  C07D471/04 ,  C07D498/08 ,  C07D417/06 ,  C07D401/06 ,  C07D401/12 ,  C07D401/04

CPC classification number: C07D213/82 ,  C07D213/63 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D417/06 ,  C07D471/04 ,  C07D487/04 ,  C07D498/08

Abstract: The present invention relates to novel oxodihydropyridinecarbohydrazide derivatives with excellent antifungal activities, an antifungal composition containing the same, and its use for the prevention and treatment of fungal infectious diseases. The oxodihydropyridinecarbohydrazide derivatives of the present invention have excellent antifungal and fungicidal activities, and thus will be useful for the prevention and treatment of various fungal infections by Candida spp., Aspergillus spp., Cryptococcus neoformans and Trichophyton spp., etc. Additionally, the oxodihydropyridinecarbohydrazide derivatives of the present invention, unlike other fungicidal preparations, can be orally administered.

Abstract translation: 本发明涉及具有优异抗真菌活性的新型氧代二氢吡啶碳酰肼衍生物，含有它们的抗真菌组合物及其用于预防和治疗真菌感染性疾病的用途。 本发明的氧代二氢吡啶碳酰肼衍生物具有优异的抗真菌和杀真菌活性，因此可用于预防和治疗念珠菌属，曲霉属（Aspergillus spp。），新隐隐球菌（Cryptococcus neoformans）和毛癣菌属（Trichophyton spp。）等各种真菌感染。另外，氧代二氢吡啶碳酰肼 本发明的衍生物与其它杀真菌剂不同，可以口服给药。

公开(公告)号：US20180044322A1

公开(公告)日：2018-02-15

申请号：US15556352

申请日：2016-06-07

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Joon Seok Park ,  Youn Jung Yoon ,  Min Jae Cho ,  Ho Bin Lee ,  Ja Kyung Yoo ,  Bong Yong Lee

IPC: C07D401/06 ,  C07D417/14 ,  C07D401/14 ,  C07D471/04

CPC classification number: C07D401/06 ,  C07D401/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention relates to a heterocyclic compound having a novel structure that can be used in the prevention or treatment of diseases caused by abnormality in a PRS (prolyl-tRNA synthetase) activity, a method for preparing the same, and a pharmaceutical composition comprising the same.

公开(公告)号：US20250051302A1

公开(公告)日：2025-02-13

申请号：US18719677

申请日：2022-12-16

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Joon-Hwan Lee ,  Min Jae Cho ,  Joon Seok Park

IPC: C07D401/06 ,  C12P17/12

Abstract: The present invention relates to a method for preparing (2R, 3S)-2-(benzo[d]imidazolylpropyl)piperidin-3-ol derivatives, and the preparation method according to the present invention has the advantage that the compound can be prepared in high yield even with a shortened process.

公开(公告)号：US10011586B2

公开(公告)日：2018-07-03

申请号：US15556352

申请日：2016-06-07

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Joon Seok Park ,  Youn Jung Yoon ,  Min Jae Cho ,  Ho Bin Lee ,  Ja Kyung Yoo ,  Bong Yong Lee

IPC: C07D401/06 ,  C07D417/14 ,  C07D401/14 ,  C07D471/04

CPC classification number: C07D401/06 ,  A61P35/00 ,  C07D401/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention relates to a heterocyclic compound having a novel structure that can be used in the prevention or treatment of diseases caused by abnormality in a PRS (prolyl-tRNA synthetase) activity, a method for preparing the same, and a pharmaceutical composition comprising the same.

公开(公告)号：US09617216B2

公开(公告)日：2017-04-11

申请号：US15029638

申请日：2014-10-21

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Joon Seok Park ,  Youn Jung Yoon ,  Chang Min Park ,  Yun Soo Na ,  Min Jae Cho ,  Ho Bin Lee ,  Mi Ryeong Han ,  Yeon Jung Park ,  Ji Duck Kim

IPC: C07D213/63 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  A61K31/4412 ,  A61P31/04 ,  C07D213/82 ,  C07D417/06 ,  C07D487/04 ,  C07D498/08 ,  C07D471/04

CPC classification number: C07D213/82 ,  C07D213/63 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D417/06 ,  C07D471/04 ,  C07D487/04 ,  C07D498/08

Abstract: The present invention relates to novel oxodihydropyridinecarbohydrazide derivatives with excellent antifungal activities, an antifungal composition containing the same, and its use for the prevention and treatment of fungal infectious diseases. The oxodihydropyridinecarbohydrazide derivatives of the present invention have excellent antifungal and fungicidal activities, and thus will be useful for the prevention and treatment of various fungal infections by Candida spp., Aspergillus spp., Cryptococcus neoformans and Trichophyton spp., etc. Additionally, the oxodihydropyridinecarbohydrazide derivatives of the present invention, unlike other fungicidal preparations, can be orally administered.

公开(公告)号：US20150336944A1

公开(公告)日：2015-11-26

申请号：US14435473

申请日：2013-10-15

Applicant: DAEWOONG PHARMACEUTICAL CO., LTD.

Inventor： Ha Young Kim ,  In Woo Kim ,  Sun Ah Jun ,  Yun Soo Na ,  Hyung Geun Lee ,  Min Jae Cho ,  Jun Hee Lee ,  Hyo Shin Kim ,  Yun Soo Yoon ,  Kyung Ha Chung ,  Ji Duck Kim

IPC: C07D417/12 ,  C07D417/14

CPC classification number: C07D417/12 ,  C07D417/14

Abstract: The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).

Abstract translation: 本发明涉及对钠离子通道具有阻塞作用的化合物，特别涉及Nav1.7，其制备方法及其应用。 根据本发明的由式1表示的化合物或其药学上可接受的盐，水合物，溶剂合物或异构体可以有效地用于预防或治疗疼痛，例如急性疼痛，慢性疼痛，神经性疼痛，手术后 疼痛，偏头痛，关节痛，神经病变，神经损伤，糖尿病性神经病变，神经病变，癫痫，心律失常，肌强直，共济失调，多发性硬化症，肠易激综合征，尿失禁，内脏痛，抑郁症，红斑性疼痛或阵发性极度疼痛障碍（PEPD） 。

公开(公告)号：US20250066319A1

公开(公告)日：2025-02-27

申请号：US18718904

申请日：2022-12-16

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Joon-Hwan Lee ,  Min Jae Cho ,  Ji Sung Yoon

IPC: C07D401/06 ,  A61K31/454

Abstract: The present disclosure provides novel (2R,3S)-2-(3-(4,5-dichloro-1H-benzo[d]imidazol-1 -yl)propyl)piperidin-3-ol monohydrochloride, (2R,3S)-2-(3-(4,5-dichloro-1H-benzo[d]imidazol-1 -yl)propyl)piperidin-3-ol oxalate, (2R,3S)-2-(3-(4,5-dichloro-1H-benzo[d]imidazol-1 -yl)propyl)piperidin-3-ol maleate, (2R,3S)-2-(3-(4,5-dichloro-1H-benzo[d]imidazol-1 -yl)propyl)piperidin-3-ol palmitate, and crystalline form of (2R,3S)-2-(3-(4,5-dichloro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-3-ol monohydrochloride. These novel acid addition salts and crystalline forms have low hygroscopicity and excellent severe stability under high temperature and high humidity conditions, and thus can be used pharmaceutically.

公开(公告)号：US20240238278A1

公开(公告)日：2024-07-18

申请号：US18288275

申请日：2022-05-02

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Da Jeong Bae ,  Caroline Hee Lee ,  Min Jae Cho ,  Min Young Park ,  Ji Hyeon Kim ,  Joon Seok Park

IPC: A61K31/496 ,  A61K9/20 ,  A61K9/28 ,  A61K31/4418 ,  A61K31/454 ,  A61P11/00

CPC classification number: A61K31/496 ,  A61K9/20 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2866 ,  A61K31/4418 ,  A61K31/454 ,  A61P11/00

Abstract: The present disclosure relates to a pharmaceutical composition that can be usefully used for the prevention or treatment of fibrosis. According to the present invention, there is a feature that the preventive or therapeutic effect of fibrosis can be further enhanced by using the first component and the second component in combination.

公开(公告)号：US10081634B2

公开(公告)日：2018-09-25

申请号：US15312192

申请日：2015-06-23

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Joon Seok Park ,  Youn Jung Yoon ,  Min Jae Cho ,  Ho Bin Lee ,  Ja Kyung Yoo ,  Yong Lee Bong

IPC: C07D473/40 ,  A61K31/4427 ,  C07D235/04 ,  C07D401/12 ,  C07D401/06 ,  C07D471/04

CPC classification number: C07D473/40 ,  A61K31/4427 ,  C07D235/04 ,  C07D401/06 ,  C07D401/12 ,  C07D471/04

Abstract: The present invention relates to a compound represented by chemical formula 1, which can be used for the prevention and treatment of diseases caused by abnormality in a prolyl-tRNA synthetase (PRS) activity, or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition comprising the same.

公开(公告)号：US20170088551A1

公开(公告)日：2017-03-30

申请号：US15312192

申请日：2015-06-23

Applicant: DAEWOONG PHARMACEUTICAL CO., LTD.

Inventor： Joon Seok Park ,  Youn Jung Yoon ,  Min Jae Cho ,  Ho Bin Lee ,  Ja Kyung Yoo ,  Yong Lee Bong

IPC: C07D473/40 ,  C07D471/04 ,  C07D401/06

CPC classification number: C07D473/40 ,  A61K31/4427 ,  C07D235/04 ,  C07D401/06 ,  C07D401/12 ,  C07D471/04

Abstract: The present invention relates to a compound represented by chemical formula 1, which can be used for the prevention and treatment of diseases caused by abnormality in a prolyl-tRNA synthetase (PRS) activity, or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition comprising the same.