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公开(公告)号：US20160304460A1
公开(公告)日：2016-10-20
申请号：US15029638
申请日：2014-10-21
发明人： Joon Seok Park , Youn Jung Yoon , Chang Min Park , Yun Soo Na , Min Jae Cho , Ho Bin Lee , Mi Ryeong Han , Yeon Jung Park , Ji Duck Kim
IPC分类号： C07D213/82 , C07D471/04 , C07D498/08 , C07D417/06 , C07D401/06 , C07D401/12 , C07D401/04
CPC分类号： C07D213/82 , C07D213/63 , C07D401/04 , C07D401/06 , C07D401/12 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/08
摘要： The present invention relates to novel oxodihydropyridinecarbohydrazide derivatives with excellent antifungal activities, an antifungal composition containing the same, and its use for the prevention and treatment of fungal infectious diseases. The oxodihydropyridinecarbohydrazide derivatives of the present invention have excellent antifungal and fungicidal activities, and thus will be useful for the prevention and treatment of various fungal infections by Candida spp., Aspergillus spp., Cryptococcus neoformans and Trichophyton spp., etc. Additionally, the oxodihydropyridinecarbohydrazide derivatives of the present invention, unlike other fungicidal preparations, can be orally administered.
摘要翻译： 本发明涉及具有优异抗真菌活性的新型氧代二氢吡啶碳酰肼衍生物，含有它们的抗真菌组合物及其用于预防和治疗真菌感染性疾病的用途。 本发明的氧代二氢吡啶碳酰肼衍生物具有优异的抗真菌和杀真菌活性，因此可用于预防和治疗念珠菌属，曲霉属（Aspergillus spp。），新隐隐球菌（Cryptococcus neoformans）和毛癣菌属（Trichophyton spp。）等各种真菌感染。另外，氧代二氢吡啶碳酰肼 本发明的衍生物与其它杀真菌剂不同，可以口服给药。
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公开(公告)号：US20220064155A1
公开(公告)日：2022-03-03
申请号：US17269325
申请日：2019-08-27
发明人： Wol Young Kim , Yeon Im Lee , Youn Jung Yoon , Joon Seok Park , Deok Ki Eom , Keuk-Chan Bang , Jaehyun Jung
IPC分类号： C07D417/14 , C07D471/04 , C07D413/04
摘要： The present disclosure relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same, and the compound according to the present disclosure can be usefully used for the prevention or treatment of autoimmune diseases or cancers. wherein, in Chemical Formula 1, R1, R2, X1, X2, L, Y, A and B are the same as defined in the specification.
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公开(公告)号：US20180044322A1
公开(公告)日：2018-02-15
申请号：US15556352
申请日：2016-06-07
发明人： Joon Seok Park , Youn Jung Yoon , Min Jae Cho , Ho Bin Lee , Ja Kyung Yoo , Bong Yong Lee
IPC分类号： C07D401/06 , C07D417/14 , C07D401/14 , C07D471/04
CPC分类号： C07D401/06 , C07D401/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to a heterocyclic compound having a novel structure that can be used in the prevention or treatment of diseases caused by abnormality in a PRS (prolyl-tRNA synthetase) activity, a method for preparing the same, and a pharmaceutical composition comprising the same.
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公开(公告)号：US10011586B2
公开(公告)日：2018-07-03
申请号：US15556352
申请日：2016-06-07
发明人： Joon Seok Park , Youn Jung Yoon , Min Jae Cho , Ho Bin Lee , Ja Kyung Yoo , Bong Yong Lee
IPC分类号： C07D401/06 , C07D417/14 , C07D401/14 , C07D471/04
CPC分类号： C07D401/06 , A61P35/00 , C07D401/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to a heterocyclic compound having a novel structure that can be used in the prevention or treatment of diseases caused by abnormality in a PRS (prolyl-tRNA synthetase) activity, a method for preparing the same, and a pharmaceutical composition comprising the same.
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公开(公告)号：US09617216B2
公开(公告)日：2017-04-11
申请号：US15029638
申请日：2014-10-21
发明人： Joon Seok Park , Youn Jung Yoon , Chang Min Park , Yun Soo Na , Min Jae Cho , Ho Bin Lee , Mi Ryeong Han , Yeon Jung Park , Ji Duck Kim
IPC分类号： C07D213/63 , C07D401/04 , C07D401/06 , C07D401/12 , A61K31/4412 , A61P31/04 , C07D213/82 , C07D417/06 , C07D487/04 , C07D498/08 , C07D471/04
CPC分类号： C07D213/82 , C07D213/63 , C07D401/04 , C07D401/06 , C07D401/12 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/08
摘要： The present invention relates to novel oxodihydropyridinecarbohydrazide derivatives with excellent antifungal activities, an antifungal composition containing the same, and its use for the prevention and treatment of fungal infectious diseases. The oxodihydropyridinecarbohydrazide derivatives of the present invention have excellent antifungal and fungicidal activities, and thus will be useful for the prevention and treatment of various fungal infections by Candida spp., Aspergillus spp., Cryptococcus neoformans and Trichophyton spp., etc. Additionally, the oxodihydropyridinecarbohydrazide derivatives of the present invention, unlike other fungicidal preparations, can be orally administered.
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公开(公告)号：US10081634B2
公开(公告)日：2018-09-25
申请号：US15312192
申请日：2015-06-23
发明人： Joon Seok Park , Youn Jung Yoon , Min Jae Cho , Ho Bin Lee , Ja Kyung Yoo , Yong Lee Bong
IPC分类号： C07D473/40 , A61K31/4427 , C07D235/04 , C07D401/12 , C07D401/06 , C07D471/04
CPC分类号： C07D473/40 , A61K31/4427 , C07D235/04 , C07D401/06 , C07D401/12 , C07D471/04
摘要： The present invention relates to a compound represented by chemical formula 1, which can be used for the prevention and treatment of diseases caused by abnormality in a prolyl-tRNA synthetase (PRS) activity, or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition comprising the same.
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公开(公告)号：US20170088551A1
公开(公告)日：2017-03-30
申请号：US15312192
申请日：2015-06-23
发明人： Joon Seok Park , Youn Jung Yoon , Min Jae Cho , Ho Bin Lee , Ja Kyung Yoo , Yong Lee Bong
IPC分类号： C07D473/40 , C07D471/04 , C07D401/06
CPC分类号： C07D473/40 , A61K31/4427 , C07D235/04 , C07D401/06 , C07D401/12 , C07D471/04
摘要： The present invention relates to a compound represented by chemical formula 1, which can be used for the prevention and treatment of diseases caused by abnormality in a prolyl-tRNA synthetase (PRS) activity, or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition comprising the same.
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