公开(公告)号：US20220202846A1

公开(公告)日：2022-06-30

申请号：US17310002

申请日：2020-01-09

申请人： OSAKA UNIVERSITY ,  DAICEL CORPORATION

发明人： Tomoyuki NISHIKAWA ,  Yasufumi KANEDA ,  Kunihiko YAMASHITA ,  Ayano SUZUKI ,  Kazuhiro TERAI

IPC分类号： A61K31/713 ,  C12N15/117 ,  A61P35/00

摘要： An object of the present disclosure is at least to provide a technique for stimulating immunity in mammals, and the object is fulfilled by double-stranded RNA composed of: RNA composed of a base sequence represented by a sequence A below; and RNA composed of a base sequence represented by a sequence B below, each base of an (N)13-25 portion in the base sequence represented by the sequence A and the base sequence represented by the sequence B being or not being complementary bases, and all of the bases of (N)5-10 portions in the base sequence represented by the sequence A and the base sequence represented by the sequence B being complementary bases, and a Tm value of the (N)5-10 portion being 20° C. or higher: Sequence A: 5′-UUGUCAUAUGGACAAGUCCAAGACU(N)13-25(N)5-10-3′ (SEQ ID No: 1), and Sequence B: 5′-(N)5-10(N)13-25AGUCUUGGACUUGUCCAUAUGACAA-3′ (SEQ ID No: 2).

公开(公告)号：US20240325659A1

公开(公告)日：2024-10-03

申请号：US18575953

申请日：2022-07-06

申请人： Daicel Corporation

发明人： Naoki SAKAGUCHI ,  Kunihiko YAMASHITA ,  Kazuhiro TERAI

IPC分类号： A61M5/48 ,  A61K9/00 ,  A61K48/00 ,  A61M5/20 ,  A61M5/30 ,  C12N15/87

CPC分类号： A61M5/482 ,  A61K9/0019 ,  A61K48/0016 ,  A61M5/2046 ,  A61M5/30 ,  C12N15/87

摘要： Provided herein is a method of administering a naked nucleic acid molecule to a subject. The method may include injecting the naked nucleic acid molecule to the subject, wherein the injecting exhibits a bi-phasic injection profile comprising a first phase and a second phase, the second phase being after the first phase, and the bi-phasic injection profile has (i) at least two peaks within 15 msec from the injecting, (ii) the first peak of at least 2 MPa, or (iii) the highest peak of the second phase of the bi-phasic injection within 30 msec from the injecting.

公开(公告)号：US20240226460A9

公开(公告)日：2024-07-11

申请号：US18279785

申请日：2022-02-28

申请人： DAICEL CORPORATION

发明人： Kunihiko YAMASHITA ,  Katsuya MIKI

IPC分类号： A61M5/42 ,  A61M5/30

CPC分类号： A61M5/425 ,  A61M5/30 ,  A61M2209/04

摘要： An aid of a jet injector includes a first pinching piece and a second pinching piece that face each other, and pinches a skin in a state of holding the skin with pinching surfaces facing each other and thus forms a fold shape part where the skin is raised in a fold shape; and a reception portion that is provided in the first pinching piece, exposes a fold top part vicinity region, which is a region in a vicinity of a fold top part, in the fold shape part, and can receive the nozzle portion of the jet injector.

公开(公告)号：US20240307515A1

公开(公告)日：2024-09-19

申请号：US18575949

申请日：2022-07-06

申请人： Daicel Corporation

发明人： Naoki SAKAGUCHI ,  Kunihiko YAMASHITA ,  Kazuhiro TERAI

IPC分类号： A61K39/00 ,  A61K9/00 ,  A61M5/30

CPC分类号： A61K39/0011 ,  A61K9/0019 ,  A61M5/30 ,  A61K2039/53 ,  A61K2039/54

摘要： Provided herein is a method of manufacturing a packaged vaccine personalized to a subject. Also provided is a method of administering a personalized vaccine to a subject. Further provided is an injector having an igniter and a removable cartridge.

公开(公告)号：US20240131278A1

公开(公告)日：2024-04-25

申请号：US18279785

申请日：2022-02-28

申请人： DAICEL CORPORATION

发明人： Kunihiko YAMASHITA ,  Katsuya MIKI

IPC分类号： A61M5/42 ,  A61M5/30

CPC分类号： A61M5/425 ,  A61M5/30 ,  A61M2209/04

摘要： An aid of a jet injector includes a first pinching piece and a second pinching piece that face each other, and pinches a skin in a state of holding the skin with pinching surfaces facing each other and thus forms a fold shape part where the skin is raised in a fold shape; and a reception portion that is provided in the first pinching piece, exposes a fold top part vicinity region, which is a region in a vicinity of a fold top part, in the fold shape part, and can receive the nozzle portion of the jet injector.