公开(公告)号：US20240131278A1

公开(公告)日：2024-04-25

申请号：US18279785

申请日：2022-02-28

Applicant: DAICEL CORPORATION

Inventor： Kunihiko YAMASHITA ,  Katsuya MIKI

IPC: A61M5/42 ,  A61M5/30

CPC classification number: A61M5/425 ,  A61M5/30 ,  A61M2209/04

Abstract: An aid of a jet injector includes a first pinching piece and a second pinching piece that face each other, and pinches a skin in a state of holding the skin with pinching surfaces facing each other and thus forms a fold shape part where the skin is raised in a fold shape; and a reception portion that is provided in the first pinching piece, exposes a fold top part vicinity region, which is a region in a vicinity of a fold top part, in the fold shape part, and can receive the nozzle portion of the jet injector.

公开(公告)号：US20200276392A1

公开(公告)日：2020-09-03

申请号：US16626291

申请日：2018-06-27

Applicant: DAICEL CORPORATION

Inventor： Takamasa SUZUKI ,  Shingo ATOBE ,  Hiroshi MIYAZAKI ,  Hiromitsu IGA ,  Katsuya MIKI

IPC: A61M5/20 ,  A61M5/30

Abstract: A needleless injector pressurizes a substance to be injected having an ejection pressure defined as a pressure of the substance to be injected ejected through an ejection port. The ejection pressure is raised to a first peak pressure after pressurizing is started, is lowered to a pressure lower than the first peak pressure afterward, and then is raised to a second peak pressure again. An on-completion reached depth that is an on-completion reached depth of the substance when the pressurizing portion completes pressurizing is adjustable, the on-completion reached depth being increased along with increase of the first peak pressure and being increased along with reduction of a length between peaks from a first timing at which the ejection pressure reaches the first peak pressure to a second timing at which the ejection pressure reaches the second peak pressure.

公开(公告)号：US20210038818A1

公开(公告)日：2021-02-11

申请号：US16968134

申请日：2019-02-08

Applicant: DAICEL CORPORATION

Inventor： Katsuya MIKI ,  Shingo ATOBE ,  Hiroshi MIYAZAKI ,  Ayano SUZUKI ,  Yuko SAKAGUCHI

IPC: A61M5/30

Abstract: This application relates to an injector and a method that can directly inject a solution containing biomolecules into a cell nucleus of an injection target with high efficiency. In one aspect, the injector injects the solution containing biomolecules into the injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target. The injector may include an accommodation unit for accommodating the solution containing biomolecules and a nozzle unit including an injection port through which the solution containing biomolecules flows and is injected into the injection target, the solution being pressurized. There may be a time at which an injection speed of the solution containing biomolecules is 40 m/s or more between an injection start time of the solution containing biomolecules and a time of 0.20 ms.

公开(公告)号：US20210023314A1

公开(公告)日：2021-01-28

申请号：US16968078

申请日：2019-02-08

Applicant: DAICEL CORPORATION

Inventor： Katsuya MIKI ,  Shingo ATOBE ,  Hiroshi MIYAZAKI ,  Ayano SUZUKI ,  Yuko SAKAGUCHI

IPC: A61M11/02 ,  A61M11/00 ,  A61M11/06

Abstract: This application relates to an injector in which when a solution containing biomolecules is injected into an injection target, a proportion of biomolecules that function in the injection target with respect to the injected biomolecules is large. This application also relates to a method of injecting a solution containing biomolecules into an injection target using the injector. In one aspect, the injector injects the solution containing biomolecules into the injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target. The injector may include an accommodation unit and a nozzle unit, wherein the injector satisfies a given condition.

公开(公告)号：US20220387948A1

公开(公告)日：2022-12-08

申请号：US17755621

申请日：2020-11-04

Applicant: DAICEL CORPORATION

Inventor： Kazuhiro TERAI ,  Yuko SAKAGUCHI ,  Toru KITAGUCHI ,  Katsuya MIKI

IPC: B01F23/2373 ,  B01F23/237

Abstract: This application relates to an ultra fine bubble production apparatus for producing ultra fine bubbles. The apparatus may include a container portion including a liquid and a gas, and a drive portion for pressurization in the container portion. In the pressurization, the time required for the pressure to reach the maximum pressure from the start of the pressurization can be 2.0 milliseconds or less, and the maximum pressure can be 4.00 MPa or more.

公开(公告)号：US20220017847A1

公开(公告)日：2022-01-20

申请号：US17311259

申请日：2019-11-29

Applicant: DAICEL CORPORATION

Inventor： Kazuhiro TERAI ,  Hiroshi MIYAZAKI ,  Toru KITAGUCHI ,  Yuko SAKAGUCHI ,  Katsuya MIKI

IPC: C12M3/06 ,  C12M1/26

Abstract: An object of the present disclosure is at least to provide a device that can easily introduce a substance into cells in vitro with high efficiency and in a short time, and the object is fulfilled by a device for introducing a substance into cells in vitro, the device comprising: an accommodation unit for accommodating a solution containing cells and a substance; and a driving unit for pressurization of the solution, wherein regarding the pressurization of the solution, time from when the pressurization starts until pressure reaches a maximum pressure is 2.0 msec or shorter.

公开(公告)号：US20240390590A1

公开(公告)日：2024-11-28

申请号：US18796095

申请日：2024-08-06

Applicant: DAICEL CORPORATION

Inventor： Katsuya MIKI ,  Shingo ATOBE ,  Hiroshi MIYAZAKI ,  Ayano SUZUKI ,  Yuko SAKAGUCHI

IPC: A61M5/30 ,  A61M5/20 ,  A61M11/00 ,  A61M11/02 ,  A61M11/06

Abstract: Proposed is an injector in which when a solution containing biomolecules is injected into an injection target, a proportion of biomolecules that function in the injection target with respect to the injected biomolecules is large. This application also relates to a method of injecting a solution containing biomolecules into an injection target using the injector. In one aspect, the injector injects the solution containing biomolecules into the injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target. The injector may include an accommodation unit and a nozzle unit, wherein the injector satisfies a given condition.

公开(公告)号：US20240226460A9

公开(公告)日：2024-07-11

申请号：US18279785

申请日：2022-02-28

Applicant: DAICEL CORPORATION

Inventor： Kunihiko YAMASHITA ,  Katsuya MIKI

IPC: A61M5/42 ,  A61M5/30

CPC classification number: A61M5/425 ,  A61M5/30 ,  A61M2209/04

Abstract: An aid of a jet injector includes a first pinching piece and a second pinching piece that face each other, and pinches a skin in a state of holding the skin with pinching surfaces facing each other and thus forms a fold shape part where the skin is raised in a fold shape; and a reception portion that is provided in the first pinching piece, exposes a fold top part vicinity region, which is a region in a vicinity of a fold top part, in the fold shape part, and can receive the nozzle portion of the jet injector.

公开(公告)号：US20210023302A1

公开(公告)日：2021-01-28

申请号：US16968095

申请日：2019-02-08

Applicant: DAICEL CORPORATION

Inventor： Katsuya MIKI ,  Shingo ATOBE ,  Hiroshi MIYAZAKI ,  Ayano SUZUKI ,  Yuko SAKAGUCHI

IPC: A61M5/20

Abstract: This application relates to an injector that can directly inject a solution containing biomolecules into a cell nucleus of a wide range of injection targets with high efficiency. In one aspect, the injector injects a solution containing biomolecules into an injection target from an injector main body without performing injection through a given structure in a state where the given structure is inserted into the injection target. The injector may include an accommodation unit and a nozzle unit, wherein the injector satisfies given conditions.