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公开(公告)号:US20140044686A1
公开(公告)日:2014-02-13
申请号:US13967410
申请日:2013-08-15
发明人: Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
IPC分类号: C12N5/0783 , C07K7/06
CPC分类号: A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要: A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
摘要翻译: 用于检测作为感兴趣的受试者的细胞块中的癌干细胞的分子标记,其中可以在感兴趣的受试者所含的癌干细胞中检测分子标记,但在正常细胞和癌细胞中不能检测到 这与癌症干细胞不同; 通过使用分子标记作为测量来确定感兴趣对象中癌干细胞的存在或不存在的方法; 用于确定癌干细胞的存在或不存在的试剂盒,其包含至少一种用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别来自分子标记物的基因的表达产物的表位的抗体; 能够抑制分子标记物的表达的核酸; 和包含衍生自分子标记的基因的核酸疫苗。
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公开(公告)号:US09399760B2
公开(公告)日:2016-07-26
申请号:US13967410
申请日:2013-08-15
发明人: Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
IPC分类号: A61K38/43 , C12N5/0783 , C12N15/113 , C12Q1/68 , G01N33/50 , G01N33/574 , C07K7/06
CPC分类号: A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要: A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
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公开(公告)号:US20160367628A1
公开(公告)日:2016-12-22
申请号:US15162833
申请日:2016-05-24
发明人: Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
IPC分类号: A61K38/17 , C12Q1/68 , G01N33/574
CPC分类号: A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要: A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
摘要翻译: 用于检测作为感兴趣的受试者的细胞块中的癌干细胞的分子标记,其中可以在感兴趣的受试者所含的癌干细胞中检测分子标记,但在正常细胞和癌细胞中不能检测到 这与癌症干细胞不同; 通过使用分子标记作为测量来确定感兴趣对象中癌干细胞的存在或不存在的方法; 用于确定癌干细胞的存在或不存在的试剂盒,其包含至少一种用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别来自分子标记物的基因的表达产物的表位的抗体; 能够抑制分子标记物的表达的核酸; 和包含衍生自分子标记的基因的核酸疫苗。
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公开(公告)号:US11382952B2
公开(公告)日:2022-07-12
申请号:US16110001
申请日:2018-08-23
发明人: Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
IPC分类号: A61K39/00 , A61K38/17 , C12N15/113 , C12Q1/6886 , G01N33/50 , G01N33/574 , C07K7/06 , C12N5/0783
摘要: A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
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公开(公告)号:US20190054141A1
公开(公告)日:2019-02-21
申请号:US16110001
申请日:2018-08-23
发明人: Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
IPC分类号: A61K38/17 , C12N15/113 , C12N5/0783 , C07K7/06 , G01N33/574 , G01N33/50 , C12Q1/6886
摘要: A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
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公开(公告)号:US10080776B2
公开(公告)日:2018-09-25
申请号:US15162833
申请日:2016-05-24
发明人: Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
IPC分类号: A61K38/17 , C12N15/113 , C12Q1/6886 , G01N33/50 , G01N33/574 , C07K7/06 , C12N5/0783
CPC分类号: A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要: A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
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