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    MOLECULAR MARKER FOR CANCER STEM CELL
    2.
    发明申请
    MOLECULAR MARKER FOR CANCER STEM CELL 有权
    癌症干细胞分子标记

    公开(公告)号：US20140044686A1

    公开(公告)日：2014-02-13

    申请号：US13967410

    申请日：2013-08-15

    申请人： Dainippon Sumitomo Pharma Co. Ltd. ,  Sapporo Medical University

    发明人： Toshihiko Torigoe ,  Yoshihiko Hirohashi ,  Noriyuki Satoh ,  Kenjiro Kamiguchi ,  Rena Morita ,  Satoshi Nishizawa ,  Akari Takahashi

    IPC分类号： C12N5/0783 ,  C07K7/06

    CPC分类号： A61K38/177 ,  C07K7/06 ,  C12N5/0638 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5017 ,  G01N33/574 ,  G01N33/57492 ,  G01N2333/705

    摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.

    摘要翻译： 用于检测作为感兴趣的受试者的细胞块中的癌干细胞的分子标记，其中可以在感兴趣的受试者所含的癌干细胞中检测分子标记，但在正常细胞和癌细胞中不能检测到 这与癌症干细胞不同; 通过使用分子标记作为测量来确定感兴趣对象中癌干细胞的存在或不存在的方法; 用于确定癌干细胞的存在或不存在的试剂盒，其包含至少一种用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别来自分子标记物的基因的表达产物的表位的抗体; 能够抑制分子标记物的表达的核酸; 和包含衍生自分子标记的基因的核酸疫苗。

    TUMOR ANTIGEN PEPTIDE
    4.
    发明申请
    TUMOR ANTIGEN PEPTIDE 审中-公开

    公开(公告)号：US20190117751A1

    公开(公告)日：2019-04-25

    申请号：US16065488

    申请日：2016-12-27

    申请人： Sapporo Medical University

    发明人： Toshihiko Torigoe ,  Takayuki Kanaseki ,  Vitaly Kochin ,  Yasuhiro Kikuchi

    IPC分类号： A61K39/00 ,  A61K35/17 ,  C07K16/30 ,  A61P35/00 ,  A61K31/713 ,  C07K14/705 ,  C12N15/113 ,  C12N5/12 ,  G01N33/574 ,  A61K39/39

    摘要： The object of the present invention is to provide a detecting agent for specifically detecting a tumor cell, a tumor antigen peptide-specifically presented on a tumor cell, a pharmaceutical composition useful for the prevention and/or treatment of cancer, the pharmaceutical composition containing the tumor antigen peptide as an active ingredient, etc. The above object has been achieved by a tumor antigen peptide or its motif-substituted product, the tumor antigen peptide comprising 8 to 14 consecutive amino acids in an amino acid sequence of a protein encoded by a gene selected from the group consisting of PVT1, SUV39H2, ZNF724P, SNRNP40, and DYRK4, the tumor antigen peptide having an HLA binding ability.

    MOLECULAR MARKER FOR CANCER STEM CELL
    6.
    发明申请
    MOLECULAR MARKER FOR CANCER STEM CELL 审中-公开
    癌症干细胞分子标记

    公开(公告)号：US20160367628A1

    公开(公告)日：2016-12-22

    申请号：US15162833

    申请日：2016-05-24

    申请人： Sapporo Medical University ,  Sumitomo Dainippon Pharma Co., Ltd.

    发明人： Toshihiko Torigoe ,  Yoshihiko Hirohashi ,  Noriyuki Satoh ,  Kenjiro Kamiguchi ,  Rena Morita ,  Satoshi Nishizawa ,  Akari Takahashi

    IPC分类号： A61K38/17 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： A61K38/177 ,  C07K7/06 ,  C12N5/0638 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5017 ,  G01N33/574 ,  G01N33/57492 ,  G01N2333/705

    摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.

    摘要翻译： 用于检测作为感兴趣的受试者的细胞块中的癌干细胞的分子标记，其中可以在感兴趣的受试者所含的癌干细胞中检测分子标记，但在正常细胞和癌细胞中不能检测到 这与癌症干细胞不同; 通过使用分子标记作为测量来确定感兴趣对象中癌干细胞的存在或不存在的方法; 用于确定癌干细胞的存在或不存在的试剂盒，其包含至少一种用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别来自分子标记物的基因的表达产物的表位的抗体; 能够抑制分子标记物的表达的核酸; 和包含衍生自分子标记的基因的核酸疫苗。

    TUMOR ANTIGEN PEPTIDE
    7.
    发明申请
    TUMOR ANTIGEN PEPTIDE 审中-公开

    公开(公告)号：US20170360911A1

    公开(公告)日：2017-12-21

    申请号：US15534315

    申请日：2015-12-08

    申请人： Sapporo Medical University ,  Sumitomo Dainippon Pharma Co., Ltd.

    发明人： Noriyuki Sato ,  Toshihiko Torigoe ,  Yoshihiko Hirohashi ,  Takayuki Kanaseki ,  Sho Miyamoto ,  Vitaly Kochin ,  Masashi Goto

    IPC分类号： A61K39/00 ,  C07K7/06 ,  G01N33/574 ,  C07K16/30 ,  C12N5/0783 ,  G01N33/50 ,  C12Q1/68 ,  C07K16/28

    摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by YO-XO-ZO; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.