公开(公告)号：US08401628B2

公开(公告)日：2013-03-19

申请号：US12478476

申请日：2009-06-04

申请人： Dan Li ,  Allan C. Shuros ,  Quan Ni ,  Aaron R. McCabe ,  Yunlong Zhang ,  Jaeho Kim

发明人： Dan Li ,  Allan C. Shuros ,  Quan Ni ,  Aaron R. McCabe ,  Yunlong Zhang ,  Jaeho Kim

IPC分类号： A61B5/024

CPC分类号： A61B5/0464 ,  A61B5/0215 ,  A61B5/0422 ,  A61B5/046 ,  A61N1/3622 ,  A61N1/3702

摘要： An apparatus comprises an implantable cardiac signal sensing circuit, configured to provide a sensed near-field depolarization signal from a ventricle and to provide a sensed a far-field intrinsic atrial signal using a far-field atrial sensing channel, and a controller circuit communicatively coupled to the cardiac signal sensing circuit. The controller circuit includes a P-wave detection module configured to detect an atrial depolarization in the sensed far-field intrinsic atrial signal and a tachyarrhythmia detection module configured to detect an episode of tachyarrhythmia using the sensed near-field depolarization signal and to determine whether the tachyarrhythmia episode is indicative of supraventricular tachycardia (SVT) using the detected atrial depolarization and the sensed near-field depolarization signal.

摘要翻译： 一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室的感测的近场去极化信号，并且使用远场心房感测通道提供感测到的远场固有心房信号，以及控制器电路，其通信耦合 到心脏信号感测电路。 所述控制器电路包括P波检测模块，所述P波检测模块被配置为检测所感测的远场固有心房信号中的心房去极化，以及快速性心律失常检测模块，其被配置为使用所感测的近场去极化信号来检测快速性心律失常发作，并且确定 快速性心律失常发作指示使用检测到的心房去极化和感测的近场去极化信号的室上性心动过速（SVT）。

公开(公告)号：US20080262558A1

公开(公告)日：2008-10-23

申请号：US11736286

申请日：2007-04-17

申请人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

发明人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

IPC分类号： A61N1/365

CPC分类号： A61N1/3621

摘要： A system including at least one implantable sensor circuit adapted to produce an electrical sensor signal related to one or more physiologic cardiovascular events of a subject, a therapy circuit configured to provide anti-tachycardia pacing (ATP) therapy, and a controller. The controller includes a tachyarrhythmia detection circuit and an efficacy circuit. The tachyarrhythmia detection circuit is configured to detect a tachyarrhythmia episode in the subject using the electrical sensor signal, and to determine whether the tachyarrhythmia episode is of a type that is treatable with ATP. The efficacy circuit is configured to estimate an efficacy of a currently configured ATP therapy for the subject, and the controller is configured to alter a delivery regimen of the currently configured ATP therapy when the estimated ATP therapy efficacy is deemed insufficient. Other systems and methods are described.

摘要翻译： 一种系统，包括适于产生与受试者的一个或多个生理性心血管事件相关的电传感器信号的至少一个可植入传感器电路，被配置为提供抗心动过速起搏（ATP）治疗的治疗电路和控制器。 控制器包括快速性心律失常检测电路和功效电路。 快速心律失常检测电路被配置为使用电传感器信号检测受试者的快速性心律失常发作，并且确定快速性心律失常发作是否是可用ATP治疗的类型。 功效电路被配置为估计当前配置的ATP治疗对受试者的功效，并且当估计的ATP治疗功效被认为不足时，控制器被配置为改变当前配置的ATP治疗的递送方案。 描述了其他系统和方法。

公开(公告)号：US20080021337A1

公开(公告)日：2008-01-24

申请号：US11459588

申请日：2006-07-24

申请人： Dan Li ,  Quan Ni

发明人： Dan Li ,  Quan Ni

IPC分类号： A61B5/04

CPC分类号： A61N1/37211 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0816 ,  A61B5/11 ,  A61N1/3702

摘要： A system comprising a medical device including a processor and a Z-score transformation (ZST) module. The system also includes a display in communication with the processor. The processor is adapted to receive sensor data obtained from at least first and second sensors adapted to produce a time-varying physiologic electrical sensor signal. At least one of the first and second sensors is implantable. The ZST module calculates a ZST for the sensor data received from the first sensor and a ZST for the sensor data received from the second sensor. The display is adapted to display the ZSTs in visual correspondence with each other over time.

摘要翻译： 一种包括医疗装置的系统，包括处理器和Z分数变换（ZST）模块。 该系统还包括与处理器通信的显示器。 处理器适于接收从至少第一和第二传感器获得的传感器数据，该传感器适于产生时变生理电传感器信号。 第一和第二传感器中的至少一个是可植入的。 ZST模块计算从第一个传感器接收的传感器数据的ZST和从第二个传感器接收的传感器数据的ZST。 该显示器适于随时间显示可视对应的ZST。

公开(公告)号：US08241212B2

公开(公告)日：2012-08-14

申请号：US12510927

申请日：2009-07-28

申请人： Dan Li ,  Quan Ni

发明人： Dan Li ,  Quan Ni

IPC分类号： A61B5/00 ,  A61B5/04

CPC分类号： A61N1/37211 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0816 ,  A61B5/11 ,  A61N1/3702

摘要： A system comprising a medical device including a processor and a Z-score transformation (ZST) module. The system also includes a display in communication with the processor. The processor is adapted to receive sensor data obtained from at least first and second sensors adapted to produce a time-varying physiologic electrical sensor signal. At least one of the first and second sensors is implantable. The ZST module calculates a ZST for the sensor data received from the first sensor and a ZST for the sensor data received from the second sensor. The display is adapted to display the ZSTs in visual correspondence with each other over time.

摘要翻译： 一种包括医疗装置的系统，包括处理器和Z分数变换（ZST）模块。 该系统还包括与处理器通信的显示器。 处理器适于接收从至少第一和第二传感器获得的传感器数据，该传感器适于产生时变生理电传感器信号。 第一和第二传感器中的至少一个是可植入的。 ZST模块计算从第一个传感器接收的传感器数据的ZST和从第二个传感器接收的传感器数据的ZST。 该显示器适于随时间显示可视对应的ZST。

公开(公告)号：US20090287068A1

公开(公告)日：2009-11-19

申请号：US12510927

申请日：2009-07-28

申请人： Dan Li ,  Quan Ni

发明人： Dan Li ,  Quan Ni

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61N1/37211 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0816 ,  A61B5/11 ,  A61N1/3702

摘要： A system comprising a medical device including a processor and a Z-score transformation (ZST) module. The system also includes a display in communication with the processor. The processor is adapted to receive sensor data obtained from at least first and second sensors adapted to produce a time-varying physiologic electrical sensor signal. At least one of the first and second sensors is implantable. The ZST module calculates a ZST for the sensor data received from the first sensor and a ZST for the sensor data received from the second sensor. The display is adapted to display the ZSTs in visual correspondence with each other over time.

摘要翻译： 一种包括医疗装置的系统，包括处理器和Z分数变换（ZST）模块。 该系统还包括与处理器通信的显示器。 处理器适于接收从至少第一和第二传感器获得的传感器数据，该传感器适于产生时变生理电传感器信号。 第一和第二传感器中的至少一个是可植入的。 ZST模块计算从第一个传感器接收的传感器数据的ZST和从第二个传感器接收的传感器数据的ZST。 该显示器适于随时间显示可视对应的ZST。

公开(公告)号：US07572232B2

公开(公告)日：2009-08-11

申请号：US11459588

申请日：2006-07-24

申请人： Dan Li ,  Quan Ni

发明人： Dan Li ,  Quan Ni

IPC分类号： A61B5/04

CPC分类号： A61N1/37211 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0816 ,  A61B5/11 ,  A61N1/3702

摘要： A system comprising a medical device including a processor and a Z-score transformation (ZST) module. The system also includes a display in communication with the processor. The processor is adapted to receive sensor data obtained from at least first and second sensors adapted to produce a time-varying physiologic electrical sensor signal. At least one of the first and second sensors is implantable. The ZST module calculates a ZST for the sensor data received from the first sensor and a ZST for the sensor data received from the second sensor. The display is adapted to display the ZSTs in visual correspondence with each other over time.

摘要翻译： 一种包括医疗装置的系统，包括处理器和Z分数变换（ZST）模块。 该系统还包括与处理器通信的显示器。 处理器适于接收从至少第一和第二传感器获得的传感器数据，该传感器适于产生时变生理电传感器信号。 第一和第二传感器中的至少一个是可植入的。 ZST模块计算从第一个传感器接收的传感器数据的ZST和从第二个传感器接收的传感器数据的ZST。 该显示器适于随时间显示可视对应的ZST。

公开(公告)号：US08725260B2

公开(公告)日：2014-05-13

申请号：US12366334

申请日：2009-02-05

申请人： Allan C. Shuros ,  Dan Li ,  Quan Ni

发明人： Allan C. Shuros ,  Dan Li ,  Quan Ni

IPC分类号： A61N1/00

CPC分类号： A61N1/36585 ,  A61N1/36578

摘要： Systems and methods of performing rhythm discrimination within a patient's body using sensed hemodynamic signals are disclosed. The method can include the steps of receiving an electrical activity signal from an electrode located within or near the heart, detecting an event of the heart based on the received electrical activity signal, sensing one or more mechanical measurements using a sensor located within the body, analyzing a mechanical activity signal received from the sensor, and confirming the type of event based on the mechanical and electrical activity signals. The sensor can comprise a single pressure sensor configured to sense both atrial and ventricular activity within the heart.

摘要翻译： 公开了使用感测到的血液动力学信号在患者体内进行节律辨别的系统和方法。 该方法可以包括以下步骤：从位于心脏内部或附近的电极接收电活动信号，基于接收到的电活动信号检测心脏的事件，使用位于体内的传感器感测一个或多个机械测量， 分析从传感器接收的机械活动信号，以及基于机械和电活动信号来确认事件的类型。 传感器可以包括构造成感测心脏内的心房和心室活动的单个压力传感器。

公开(公告)号：US20090306486A1

公开(公告)日：2009-12-10

申请号：US12478476

申请日：2009-06-04

申请人： Dan Li ,  Allan C. Shuros ,  Quan Ni ,  Aaron R. McCabe ,  Yunlong Zhang ,  Jaeho Kim

发明人： Dan Li ,  Allan C. Shuros ,  Quan Ni ,  Aaron R. McCabe ,  Yunlong Zhang ,  Jaeho Kim

IPC分类号： A61B5/046 ,  A61B5/02 ,  A61B5/0464

CPC分类号： A61B5/0464 ,  A61B5/0215 ,  A61B5/0422 ,  A61B5/046 ,  A61N1/3622 ,  A61N1/3702

摘要： An apparatus comprises an implantable cardiac signal sensing circuit, configured to provide a sensed near-field depolarization signal from a ventricle and to provide a sensed a far-field intrinsic atrial signal using a far-field atrial sensing channel, and a controller circuit communicatively coupled to the cardiac signal sensing circuit. The controller circuit includes a P-wave detection module configured to detect an atrial depolarization in the sensed far-field intrinsic atrial signal and a tachyarrhythmia detection module configured to detect an episode of tachyarrhythmia using the sensed near-field depolarization signal and to determine whether the tachyarrhythmia episode is indicative of supraventricular tachycardia (SVT) using the detected atrial depolarization and the sensed near-field depolarization signal.

摘要翻译： 一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室的感测的近场去极化信号，并且使用远场心房感测通道提供感测到的远场固有心房信号，以及控制器电路， 到心脏信号感测电路。 所述控制器电路包括P波检测模块，所述P波检测模块被配置为检测所感测的远场固有心房信号中的心房去极化，以及快速性心律失常检测模块，其被配置为使用所感测的近场去极化信号来检测快速性心律失常发作，并且确定是否 快速性心律失常发作指示使用检测到的心房去极化和感测的近场去极化信号的室上性心动过速（SVT）。

公开(公告)号：US07873414B2

公开(公告)日：2011-01-18

申请号：US11736286

申请日：2007-04-17

申请人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

发明人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

IPC分类号： A61N1/362

CPC分类号： A61N1/3621

摘要： A system including at least one implantable sensor circuit adapted to produce an electrical sensor signal related to one or more physiologic cardiovascular events of a subject, a therapy circuit configured to provide anti-tachycardia pacing (ATP) therapy, and a controller. The controller includes a tachyarrhythmia detection circuit and an efficacy circuit. The tachyarrhythmia detection circuit is configured to detect a tachyarrhythmia episode in the subject using the electrical sensor signal, and to determine whether the tachyarrhythmia episode is of a type that is treatable with ATP. The efficacy circuit is configured to estimate an efficacy of a currently configured ATP therapy for the subject, and the controller is configured to alter a delivery regimen of the currently configured ATP therapy when the estimated ATP therapy efficacy is deemed insufficient. Other systems and methods are described.

摘要翻译： 一种系统，包括适于产生与受试者的一个或多个生理性心血管事件相关的电传感器信号的至少一个可植入传感器电路，被配置为提供抗心动过速起搏（ATP）治疗的治疗电路和控制器。 控制器包括快速性心律失常检测电路和功效电路。 快速心律失常检测电路被配置为使用电传感器信号检测受试者的快速性心律失常发作，并且确定快速性心律失常发作是否是可用ATP治疗的类型。 功效电路被配置为估计当前配置的ATP治疗对受试者的功效，并且当估计的ATP治疗功效被认为不足时，控制器被配置为改变当前配置的ATP治疗的递送方案。 描述其他系统和方法。

公开(公告)号：US20090204163A1

公开(公告)日：2009-08-13

申请号：US12366334

申请日：2009-02-05

申请人： Allan C. Shuros ,  Dan Li ,  Quan Ni

发明人： Allan C. Shuros ,  Dan Li ,  Quan Ni

IPC分类号： A61N1/365

CPC分类号： A61N1/36585 ,  A61N1/36578

摘要： Systems and methods of performing rhythm discrimination within a patient's body using sensed hemodynamic signals are disclosed. The method can include the steps of receiving an electrical activity signal from an electrode located within or near the heart, detecting an event of the heart based on the received electrical activity signal, sensing one or more mechanical measurements using a sensor located within the body, analyzing a mechanical activity signal received from the sensor, and confirming the type of event based on the mechanical and electrical activity signals. The sensor can comprise a single pressure sensor configured to sense both atrial and ventricular activity within the heart.

摘要翻译： 公开了使用感测到的血液动力学信号在患者体内进行节律辨别的系统和方法。 该方法可以包括以下步骤：从位于心脏内部或附近的电极接收电活动信号，基于接收到的电活动信号检测心脏的事件，使用位于体内的传感器感测一个或多个机械测量， 分析从传感器接收的机械活动信号，以及基于机械和电活动信号来确认事件的类型。 传感器可以包括构造成感测心脏内的心房和心室活动的单个压力传感器。