公开(公告)号：US07873414B2

公开(公告)日：2011-01-18

申请号：US11736286

申请日：2007-04-17

申请人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

发明人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

IPC分类号： A61N1/362

CPC分类号： A61N1/3621

摘要： A system including at least one implantable sensor circuit adapted to produce an electrical sensor signal related to one or more physiologic cardiovascular events of a subject, a therapy circuit configured to provide anti-tachycardia pacing (ATP) therapy, and a controller. The controller includes a tachyarrhythmia detection circuit and an efficacy circuit. The tachyarrhythmia detection circuit is configured to detect a tachyarrhythmia episode in the subject using the electrical sensor signal, and to determine whether the tachyarrhythmia episode is of a type that is treatable with ATP. The efficacy circuit is configured to estimate an efficacy of a currently configured ATP therapy for the subject, and the controller is configured to alter a delivery regimen of the currently configured ATP therapy when the estimated ATP therapy efficacy is deemed insufficient. Other systems and methods are described.

摘要翻译： 一种系统，包括适于产生与受试者的一个或多个生理性心血管事件相关的电传感器信号的至少一个可植入传感器电路，被配置为提供抗心动过速起搏（ATP）治疗的治疗电路和控制器。 控制器包括快速性心律失常检测电路和功效电路。 快速心律失常检测电路被配置为使用电传感器信号检测受试者的快速性心律失常发作，并且确定快速性心律失常发作是否是可用ATP治疗的类型。 功效电路被配置为估计当前配置的ATP治疗对受试者的功效，并且当估计的ATP治疗功效被认为不足时，控制器被配置为改变当前配置的ATP治疗的递送方案。 描述其他系统和方法。

公开(公告)号：US20080262558A1

公开(公告)日：2008-10-23

申请号：US11736286

申请日：2007-04-17

申请人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

发明人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

IPC分类号： A61N1/365

CPC分类号： A61N1/3621

摘要： A system including at least one implantable sensor circuit adapted to produce an electrical sensor signal related to one or more physiologic cardiovascular events of a subject, a therapy circuit configured to provide anti-tachycardia pacing (ATP) therapy, and a controller. The controller includes a tachyarrhythmia detection circuit and an efficacy circuit. The tachyarrhythmia detection circuit is configured to detect a tachyarrhythmia episode in the subject using the electrical sensor signal, and to determine whether the tachyarrhythmia episode is of a type that is treatable with ATP. The efficacy circuit is configured to estimate an efficacy of a currently configured ATP therapy for the subject, and the controller is configured to alter a delivery regimen of the currently configured ATP therapy when the estimated ATP therapy efficacy is deemed insufficient. Other systems and methods are described.

摘要翻译： 一种系统，包括适于产生与受试者的一个或多个生理性心血管事件相关的电传感器信号的至少一个可植入传感器电路，被配置为提供抗心动过速起搏（ATP）治疗的治疗电路和控制器。 控制器包括快速性心律失常检测电路和功效电路。 快速心律失常检测电路被配置为使用电传感器信号检测受试者的快速性心律失常发作，并且确定快速性心律失常发作是否是可用ATP治疗的类型。 功效电路被配置为估计当前配置的ATP治疗对受试者的功效，并且当估计的ATP治疗功效被认为不足时，控制器被配置为改变当前配置的ATP治疗的递送方案。 描述了其他系统和方法。

公开(公告)号：US20100305642A1

公开(公告)日：2010-12-02

申请号：US12781459

申请日：2010-05-17

申请人： Yanting Dong ,  David L. Perschbacher ,  Jeffrey E. Stahmann ,  Dan Li ,  Deepa Mahajan

发明人： Yanting Dong ,  David L. Perschbacher ,  Jeffrey E. Stahmann ,  Dan Li ,  Deepa Mahajan

IPC分类号： A61N1/00

CPC分类号： A61N1/37252 ,  A61B5/02 ,  A61B5/04 ,  A61B5/0452 ,  A61B5/6846 ,  A61N1/025 ,  A61N1/3621 ,  A61N1/3702 ,  A61N1/372 ,  A61N1/3925

摘要： Monitoring physiological parameter using an implantable physiological monitor in order to detect a condition predictive of a possible future pathological episode and collecting additional physiological data associated with the condition predictive of a possible future pathological episode. Monitoring another physiological parameter in order to detect a condition indicative of the beginning of a present pathological episode and collecting additional pathological data in response to the condition. Determining that the condition predictive of a future episode and the condition indicative of a present episode are associated and, in response thereto, storing all the collected physiological data.

摘要翻译： 使用植入式生理监测器监测生理参数，以便检测预测可能的未来病理发作的状况并收集与预测可能的未来病理发作相关的条件相关的附加生理数据。 监测另一个生理参数，以便检测指示本病理发作开始的病症，并根据病情收集额外的病理资料。 确定预测未来事件的状况和指示当前情节的状况是相关联的，并且响应于此，存储所有收集的生理数据。

公开(公告)号：US09510764B2

公开(公告)日：2016-12-06

申请号：US12754932

申请日：2010-04-06

申请人： Dan Li ,  David L. Perschbacher ,  Yanting Dong ,  Julie Stephenson

发明人： Dan Li ,  David L. Perschbacher ,  Yanting Dong ,  Julie Stephenson

IPC分类号： A61B5/0464 ,  A61B5/00 ,  A61B5/04 ,  A61N1/362 ,  A61N1/365

CPC分类号： A61B5/0464 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/686 ,  A61N1/3624 ,  A61N1/36592

摘要： An apparatus comprises an implantable cardiac signal sensing circuit configured to provide a sensed depolarization signal from a ventricle and a processor. The processor includes a signal analyzer module and a tachyarrhythmia discrimination module. The signal analyzer module is configured to determine a measure of stability of ventricular (V-V) depolarization intervals using the depolarization signal, and determine a rate of change of the measure of stability. The tachyarrhythmia discrimination module is configured to detect an episode of tachyarrhythmia using the depolarization signal, determine whether the detected tachyarrhythmia is indicative of atrial tachyarrhythmia using the determined rate of change, and provide the determination to a user or process.

摘要翻译： 一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室和处理器的感测去极化信号。 处理器包括信号分析器模块和快速心律失常辨别模块。 信号分析器模块被配置为使用去极化信号来确定心室（V-V）去极化间隔的稳定性的量度，并且确定稳定性测量的变化率。 快速心律失常辨别模块被配置为使用去极化信号来检测快速性心律失常发作，使用确定的变化率确定检测到的快速性心律失常是指示心房快速性心律失常，并且向用户或过程提供确定。

公开(公告)号：US08483808B2

公开(公告)日：2013-07-09

申请号：US12879147

申请日：2010-09-10

申请人： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

发明人： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

IPC分类号： A61N5/0472 ,  A61B5/0452

CPC分类号： A61B5/04525 ,  G06K9/00536

摘要： A system and method for automatically analyzing a cardiac signal, including the step of providing an episode database on a computer storage medium including a plurality of episode data records of one or more patients. Each episode data record includes a cardiac signal from at least one data-generating device. The method also includes the step of selecting one or more of the N beats to be one or more beat templates, for at least a first cardiac signal having N beats. Another step is determining a value K for the cardiac signal using a computer system where K beat templates can represent all the N beats in the cardiac signal.

摘要翻译： 一种用于自动分析心脏信号的系统和方法，包括在包括一个或多个患者的多个发作数据记录的计算机存储介质上提供情节数据库的步骤。 每个剧集数据记录包括来自至少一个数据生成装置的心脏信号。 该方法还包括为至少具有N次拍子的第一个心脏信号选择N个节拍中的一个或多个作为一个或多个节拍模板的步骤。 另一步是使用计算机系统确定心脏信号的值K，其中K搏动模板可以表示心脏信号中的所有N个搏动。

公开(公告)号：US20110130666A1

公开(公告)日：2011-06-02

申请号：US12916843

申请日：2010-11-01

申请人： Yanting Dong ,  David L. Perschbacher ,  Dan Li ,  Deepa Mahajan ,  F. Roosevelt Gilliam

发明人： Yanting Dong ,  David L. Perschbacher ,  Dan Li ,  Deepa Mahajan ,  F. Roosevelt Gilliam

IPC分类号： A61B5/0205 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/0464

CPC分类号： A61B5/04525 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/02438 ,  A61B5/0464 ,  A61B5/0816 ,  A61B5/14503 ,  A61B7/00 ,  A61N1/36521 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36578

摘要： An apparatus comprises a sensor circuit configured to produce a time-varying physiologic sensor signal of a subject and a pathology detection circuit communicatively coupled to the sensor. The pathology detection circuit is configured to detect a first pathological episode using the sensed physiologic sensor signal, deem that the first pathological episode has ended, detect at least one second pathological episode using the sensed physiologic sensor signal, and indicate the first and second pathological episodes as one pathological episode if the first and second episode are detected within a specified time interval.

摘要翻译： 一种装置包括被配置为产生受试者的时变生理传感器信号的传感器电路和通信地耦合到传感器的病理检测电路。 病理检测电路被配置为使用感测到的生理传感器信号来检测第一病理发作，认为第一病理发作已经结束，使用感测到的生理传感器信号检测至少一个第二病理发作，并且指示第一和第二病理发作 作为一个病理发作，如果在指定的时间间隔内检测到第一和第二集。

公开(公告)号：US09008760B2

公开(公告)日：2015-04-14

申请号：US13483394

申请日：2012-05-30

申请人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

发明人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

IPC分类号： A61B5/04 ,  A61B5/0452 ,  A61B5/00 ,  A61B5/0245 ,  A61B5/042 ,  A61N1/37

CPC分类号： A61B5/0452 ,  A61B5/0245 ,  A61B5/042 ,  A61B5/7217 ,  A61N1/3704

摘要： A system and method for performing off-line analysis of cardiac electrogram data, comprising: retrieving an electrogram from a memory location; identifying a first-channel group of candidate beats from at least a first channel of the electrogram; and identifying a second-channel group of candidate beats from at least a second channel of an electrogram. For each first-channel beat candidate near a second-channel beat candidate, the amplitude of the first-channel beat candidate is compared with the amplitude of a previous beat and the amplitude of a next beat on the first electrogram channel, and first-channel beat candidates that are outside of a first pre-determined range from either the previous or next beat are removed. Then first-channel beat candidates that are outside of a second pre-determined range from either the previous or next beat candidate are removed.

摘要翻译： 一种用于执行心电图数据的离线分析的系统和方法，包括：从存储器位置检索电描记图; 从所述电描记图的至少第一通道识别候选节拍的第一通道组; 以及从电描记图的至少第二通道识别候选节拍的第二通道组。 对于靠近第二声道拍子候选的每个第一声道拍子候选，将第一声道拍子候选的幅度与先前拍子的幅度和第一电摄影通道上的下一拍子的幅度进行比较，并且将第一声道 从前一个或下一个节拍中跳出超出第一个预定范围之外的候选人被删除。 然后，除去来自前一个或下一个节拍候选的第二预定范围之外的第一声道拍子候选。

公开(公告)号：US20130138005A1

公开(公告)日：2013-05-30

申请号：US13483394

申请日：2012-05-30

申请人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

发明人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61B5/0245 ,  A61B5/042 ,  A61B5/7217 ,  A61N1/3704

摘要： A system and method for performing off-line analysis of cardiac electrogram data, comprising: retrieving an electrogram from a memory location; identifying a first-channel group of candidate beats from at least a first channel of the electrogram; and identifying a second-channel group of candidate beats from at least a second channel of an electrogram. For each first-channel beat candidate near a second-channel beat candidate, the amplitude of the first-channel beat candidate is compared with the amplitude of a previous beat and the amplitude of a next beat on the first electrogram channel, and first-channel beat candidates that are outside of a first pre-determined range from either the previous or next beat are removed. Then first-channel beat candidates that are outside of a second pre-determined range from either the previous or next beat candidate are removed.

摘要翻译： 一种用于执行心电图数据的离线分析的系统和方法，包括：从存储器位置检索电描记图; 从所述电描记图的至少第一通道识别候选节拍的第一通道组; 以及从电描记图的至少第二通道识别候选节拍的第二通道组。 对于靠近第二声道拍子候选的每个第一声道拍子候选，将第一声道拍子候选的幅度与先前拍子的幅度和第一电摄影频道上的下一拍子的幅度进行比较，并且将第一声道 从前一个或下一个节拍中跳出超出第一个预定范围之外的候选人被删除。 然后，除去来自前一个或下一个节拍候选的第二预定范围之外的第一声道拍子候选。

公开(公告)号：US08649860B2

公开(公告)日：2014-02-11

申请号：US12781459

申请日：2010-05-17

申请人： Yanting Dong ,  David L. Perschbacher ,  Jeffrey E. Stahmann ,  Dan Li ,  Deepa Mahajan

发明人： Yanting Dong ,  David L. Perschbacher ,  Jeffrey E. Stahmann ,  Dan Li ,  Deepa Mahajan

IPC分类号： A61N1/39

CPC分类号： A61N1/37252 ,  A61B5/02 ,  A61B5/04 ,  A61B5/0452 ,  A61B5/6846 ,  A61N1/025 ,  A61N1/3621 ,  A61N1/3702 ,  A61N1/372 ,  A61N1/3925

摘要： Monitoring physiological parameter using an implantable physiological monitor in order to detect a condition predictive of a possible future pathological episode and collecting additional physiological data associated with the condition predictive of a possible future pathological episode. Monitoring another physiological parameter in order to detect a condition indicative of the beginning of a present pathological episode and collecting additional pathological data in response to the condition. Determining that the condition predictive of a future episode and the condition indicative of a present episode are associated and, in response thereto, storing all the collected physiological data.

摘要翻译： 使用植入式生理监测器监测生理参数，以便检测预测可能的未来病理发作的状况并收集与预测可能的未来病理发作相关的条件相关的附加生理数据。 监测另一个生理参数，以便检测指示本病理发作开始的病症，并根据病情收集额外的病理资料。 确定预测未来事件的状况和指示当前情节的状况是相关联的，并且响应于此，存储所有收集的生理数据。

公开(公告)号：US20130138004A1

公开(公告)日：2013-05-30

申请号：US13483387

申请日：2012-05-30

申请人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

发明人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

IPC分类号： A61B5/04 ,  A61N1/39

CPC分类号： A61B5/04012 ,  A61B5/0245 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/7217 ,  A61N1/3704 ,  A61N1/3937

摘要： A system and method for performing independent, off-line evaluation of event sensing for collected electrograms, comprising: sensing an electrogram using an implantable medical device (IMD); determining locations of heart beats on at least one channel of the electrogram using a multi-pass process, resulting in a group of multi-pass beat locations; storing the electrogram and device-identified beat locations in a memory location; and retrieving the electrogram and device-identified beat locations from the memory location. The multi-pass process determines locations of heart beats on at least a first channel of the electrogram. The device-identified group of beat locations are then compared to the multi-pass group of beat locations identified using the multi-pass method. Based on the comparing step, oversensing of beats, undersensing of beats, or noise from the device can be detected.

摘要翻译： 一种用于对收集的电描记图执行事件感测的独立离线评估的系统和方法，包括：使用可植入医疗装置（IMD）感测电描记图; 使用多遍处理确定心电图的至少一个通道上的心跳位置，从而产生一组多通拍位置; 将电描记图和设备识别的节拍位置存储在存储器位置中; 以及从存储器位置检索电描记图和设备标识的拍摄位置。 多遍处理确定心电图的至少第一个通道的位置。 然后将设备识别的拍摄位置组与使用多遍方法识别的拍摄位置的多通道组进行比较。 基于比较步骤，可以检测节拍过度，节拍不足或来自装置的噪音。