公开(公告)号：US08532762B2

公开(公告)日：2013-09-10

申请号：US11312279

申请日：2005-12-20

申请人： Shelley Cazares ,  Carlos Ricci ,  Dan Li ,  Yayun Lin ,  Yi Zhang ,  Jaeho Kim ,  Joseph Bocek

发明人： Shelley Cazares ,  Carlos Ricci ,  Dan Li ,  Yayun Lin ,  Yi Zhang ,  Jaeho Kim ,  Joseph Bocek

IPC分类号： A61N1/365

CPC分类号： A61N1/3622 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/7264 ,  A61N1/3702 ,  A61N1/3962

摘要： Cardiac arrhythmias are classified based on the morphology of the arrhythmia episode beats. Templates are formed using morphological features of the cardiac beats of the episode. The arrhythmia episode is classified as a monomorphic tachyarrhythmia or polymorphic tachyarrhythmia based on the one or more templates. The arrhythmia episode may be classified based on a number templates formed from the arrhythmia episode. The templates are formed by determining a measure of similarity between morphological features of a cardiac beat to a template. The similarities can be determined based on a pairing rule that determines which beat morphologies are compared. Selection of therapy for treating the arrhythmia episode may depend on the historical success of a therapy at mitigating previous arrhythmias of the same type as the arrhythmia episode.

摘要翻译： 心律失常根据心律失常发作的形态进行分类。 使用情节心脏搏动的形态学特征形成模板。 基于一个或多个模板，心律失常发作被分类为单形性快速性心律失常或多态性快速性心律失常。 心律失常发作可以基于由心律失常发作形成的数字模板进行分类。 模板通过确定心跳的形态特征与模板之间的相似性的度量来形成。 可以基于确定哪些拍子形态进行比较的配对规则来确定相似度。 选择治疗心律失常发作的治疗可能取决于治疗在缓解与心律失常事件相同类型的以前心律失常方面的历史成功。

公开(公告)号：US20130138004A1

公开(公告)日：2013-05-30

申请号：US13483387

申请日：2012-05-30

申请人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

发明人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

IPC分类号： A61B5/04 ,  A61N1/39

CPC分类号： A61B5/04012 ,  A61B5/0245 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/7217 ,  A61N1/3704 ,  A61N1/3937

摘要： A system and method for performing independent, off-line evaluation of event sensing for collected electrograms, comprising: sensing an electrogram using an implantable medical device (IMD); determining locations of heart beats on at least one channel of the electrogram using a multi-pass process, resulting in a group of multi-pass beat locations; storing the electrogram and device-identified beat locations in a memory location; and retrieving the electrogram and device-identified beat locations from the memory location. The multi-pass process determines locations of heart beats on at least a first channel of the electrogram. The device-identified group of beat locations are then compared to the multi-pass group of beat locations identified using the multi-pass method. Based on the comparing step, oversensing of beats, undersensing of beats, or noise from the device can be detected.

摘要翻译： 一种用于对收集的电描记图执行事件感测的独立离线评估的系统和方法，包括：使用可植入医疗装置（IMD）感测电描记图; 使用多遍处理确定心电图的至少一个通道上的心跳位置，从而产生一组多通拍位置; 将电描记图和设备识别的节拍位置存储在存储器位置中; 以及从存储器位置检索电描记图和设备标识的拍摄位置。 多遍处理确定心电图的至少第一个通道的位置。 然后将设备识别的拍摄位置组与使用多遍方法识别的拍摄位置的多通道组进行比较。 基于比较步骤，可以检测节拍过度，节拍不足或来自装置的噪音。

公开(公告)号：US20110166613A1

公开(公告)日：2011-07-07

申请号：US13048582

申请日：2011-03-15

申请人： Dan Li ,  Yayun Lin

发明人： Dan Li ,  Yayun Lin

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/3622 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/36585 ,  A61N1/3962

摘要： Methods and systems for selecting tachyarrhythmia therapy based on the morphological organization level of the arrhythmia are described. Morphological organization levels of arrhythmias are associated with cardiac therapies. The morphological organization levels are related to cardiac signal morphologies of the arrhythmias. An arrhythmia episode is detected and the morphological organization level of the arrhythmia episode is determined. A cardiac therapy associated with the morphological organization level of the arrhythmia episode is delivered to treat the arrhythmia. For example, the morphological organization levels may be associated with the cardiac therapies based on one or more of retrospective database analysis, patient therapy tolerance, and physician input. The associations may be static or may be dynamically adjusted based on therapy efficacy.

摘要翻译： 描述了基于心律失常形态组织水平选择快速性心律失常治疗的方法和系统。 心律失常的形态学组织水平与心脏治疗有关。 形态组织水平与心律失常的心脏信号形态有关。 检测到心律失常发作，确定心律失常发作的形态组织水平。 与心律失常发作的形态组织水平相关的心脏治疗被递送以治疗心律失常。 例如，形态组织水平可以基于回顾性数据库分析，患者治疗耐受性和医师输入中的一种或多种与心脏疗法相关联。 协会可以是静态的，或者可以基于治疗功效来动态调整。

公开(公告)号：US09008760B2

公开(公告)日：2015-04-14

申请号：US13483394

申请日：2012-05-30

申请人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

发明人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

IPC分类号： A61B5/04 ,  A61B5/0452 ,  A61B5/00 ,  A61B5/0245 ,  A61B5/042 ,  A61N1/37

CPC分类号： A61B5/0452 ,  A61B5/0245 ,  A61B5/042 ,  A61B5/7217 ,  A61N1/3704

摘要： A system and method for performing off-line analysis of cardiac electrogram data, comprising: retrieving an electrogram from a memory location; identifying a first-channel group of candidate beats from at least a first channel of the electrogram; and identifying a second-channel group of candidate beats from at least a second channel of an electrogram. For each first-channel beat candidate near a second-channel beat candidate, the amplitude of the first-channel beat candidate is compared with the amplitude of a previous beat and the amplitude of a next beat on the first electrogram channel, and first-channel beat candidates that are outside of a first pre-determined range from either the previous or next beat are removed. Then first-channel beat candidates that are outside of a second pre-determined range from either the previous or next beat candidate are removed.

摘要翻译： 一种用于执行心电图数据的离线分析的系统和方法，包括：从存储器位置检索电描记图; 从所述电描记图的至少第一通道识别候选节拍的第一通道组; 以及从电描记图的至少第二通道识别候选节拍的第二通道组。 对于靠近第二声道拍子候选的每个第一声道拍子候选，将第一声道拍子候选的幅度与先前拍子的幅度和第一电摄影通道上的下一拍子的幅度进行比较，并且将第一声道 从前一个或下一个节拍中跳出超出第一个预定范围之外的候选人被删除。 然后，除去来自前一个或下一个节拍候选的第二预定范围之外的第一声道拍子候选。

公开(公告)号：US20130138005A1

公开(公告)日：2013-05-30

申请号：US13483394

申请日：2012-05-30

申请人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

发明人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61B5/0245 ,  A61B5/042 ,  A61B5/7217 ,  A61N1/3704

摘要： A system and method for performing off-line analysis of cardiac electrogram data, comprising: retrieving an electrogram from a memory location; identifying a first-channel group of candidate beats from at least a first channel of the electrogram; and identifying a second-channel group of candidate beats from at least a second channel of an electrogram. For each first-channel beat candidate near a second-channel beat candidate, the amplitude of the first-channel beat candidate is compared with the amplitude of a previous beat and the amplitude of a next beat on the first electrogram channel, and first-channel beat candidates that are outside of a first pre-determined range from either the previous or next beat are removed. Then first-channel beat candidates that are outside of a second pre-determined range from either the previous or next beat candidate are removed.

摘要翻译： 一种用于执行心电图数据的离线分析的系统和方法，包括：从存储器位置检索电描记图; 从所述电描记图的至少第一通道识别候选节拍的第一通道组; 以及从电描记图的至少第二通道识别候选节拍的第二通道组。 对于靠近第二声道拍子候选的每个第一声道拍子候选，将第一声道拍子候选的幅度与先前拍子的幅度和第一电摄影频道上的下一拍子的幅度进行比较，并且将第一声道 从前一个或下一个节拍中跳出超出第一个预定范围之外的候选人被删除。 然后，除去来自前一个或下一个节拍候选的第二预定范围之外的第一声道拍子候选。

公开(公告)号：US08583228B2

公开(公告)日：2013-11-12

申请号：US13048582

申请日：2011-03-15

申请人： Dan Li ,  Yayun Lin

发明人： Dan Li ,  Yayun Lin

IPC分类号： A61N1/00

CPC分类号： A61N1/3622 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/36585 ,  A61N1/3962

摘要： Methods and systems for selecting tachyarrhythmia therapy based on the morphological organization level of the arrhythmia are described. Morphological organization levels of arrhythmias are associated with cardiac therapies. The morphological organization levels are related to cardiac signal morphologies of the arrhythmias. An arrhythmia episode is detected and the morphological organization level of the arrhythmia episode is determined. A cardiac therapy associated with the morphological organization level of the arrhythmia episode is delivered to treat the arrhythmia. For example, the morphological organization levels may be associated with the cardiac therapies based on one or more of retrospective database analysis, patient therapy tolerance, and physician input. The associations may be static or may be dynamically adjusted based on therapy efficacy.

摘要翻译： 描述了基于心律失常形态组织水平选择快速性心律失常治疗的方法和系统。 心律失常的形态学组织水平与心脏治疗有关。 形态组织水平与心律失常的心脏信号形态有关。 检测到心律失常发作，确定心律失常发作的形态组织水平。 与心律失常发作的形态组织水平相关的心脏治疗被递送以治疗心律失常。 例如，形态组织水平可以基于回顾性数据库分析，患者治疗耐受性和医师输入中的一种或多种与心脏疗法相关联。 协会可以是静态的，或者可以基于治疗功效来动态调整。

公开(公告)号：US08483808B2

公开(公告)日：2013-07-09

申请号：US12879147

申请日：2010-09-10

申请人： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

发明人： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

IPC分类号： A61N5/0472 ,  A61B5/0452

CPC分类号： A61B5/04525 ,  G06K9/00536

摘要： A system and method for automatically analyzing a cardiac signal, including the step of providing an episode database on a computer storage medium including a plurality of episode data records of one or more patients. Each episode data record includes a cardiac signal from at least one data-generating device. The method also includes the step of selecting one or more of the N beats to be one or more beat templates, for at least a first cardiac signal having N beats. Another step is determining a value K for the cardiac signal using a computer system where K beat templates can represent all the N beats in the cardiac signal.

摘要翻译： 一种用于自动分析心脏信号的系统和方法，包括在包括一个或多个患者的多个发作数据记录的计算机存储介质上提供情节数据库的步骤。 每个剧集数据记录包括来自至少一个数据生成装置的心脏信号。 该方法还包括为至少具有N次拍子的第一个心脏信号选择N个节拍中的一个或多个作为一个或多个节拍模板的步骤。 另一步是使用计算机系统确定心脏信号的值K，其中K搏动模板可以表示心脏信号中的所有N个搏动。

公开(公告)号：US20070049974A1

公开(公告)日：2007-03-01

申请号：US11209976

申请日：2005-08-23

申请人： Dan Li ,  Yayun Lin

发明人： Dan Li ,  Yayun Lin

IPC分类号： A61N1/00

CPC分类号： A61N1/3622 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/36585 ,  A61N1/3962

摘要： Methods and systems for selecting tachyarrhythmia therapy based on the morphological organization level of the arrhythmia are described. Morphological organization levels of arrhythmias are associated with cardiac therapies. The morphological organization levels are related to cardiac signal morphologies of the arrhythmias. An arrhythmia episode is detected and the morphological organization level of the arrhythmia episode is determined. A cardiac therapy associated with the morphological organization level of the arrhythmia episode is delivered to treat the arrhythmia. For example, the morphological organization levels may be associated with the cardiac therapies based on one or more of retrospective database analysis patient therapy tolerance, and physician input. The associations may be static or may be dynamically adjusted based on therapy efficacy.

摘要翻译： 描述了基于心律失常形态组织水平选择快速性心律失常治疗的方法和系统。 心律失常的形态学组织水平与心脏治疗有关。 形态组织水平与心律失常的心脏信号形态有关。 检测到心律失常发作，确定心律失常发作的形态组织水平。 与心律失常发作的形态组织水平相关的心脏治疗被递送以治疗心律失常。 例如，形态组织水平可以基于回顾性数据库分析患者治疗耐受性和医师输入中的一种或多种与心脏治疗相关联。 协会可以是静态的，或者可以基于治疗功效来动态调整。

公开(公告)号：US08942791B2

公开(公告)日：2015-01-27

申请号：US13483387

申请日：2012-05-30

申请人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

发明人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

IPC分类号： A61B5/04 ,  A61N1/39

CPC分类号： A61B5/04012 ,  A61B5/0245 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/7217 ,  A61N1/3704 ,  A61N1/3937

摘要： A system and method for performing independent, off-line evaluation of event sensing for collected electrograms, comprising: sensing an electrogram using an implantable medical device (IMD); determining locations of heart beats on at least one channel of the electrogram using a multi-pass process, resulting in a group of multi-pass beat locations; storing the electrogram and device-identified beat locations in a memory location; and retrieving the electrogram and device-identified beat locations from the memory location. The multi-pass process determines locations of heart beats on at least a first channel of the electrogram. The device-identified group of beat locations are then compared to the multi-pass group of beat locations identified using the multi-pass method. Based on the comparing step, oversensing of beats, undersensing of beats, or noise from the device can be detected.

摘要翻译： 一种用于对收集的电描记图执行事件感测的独立离线评估的系统和方法，包括：使用可植入医疗装置（IMD）感测电描记图; 使用多遍处理确定心电图的至少一个通道上的心跳位置，从而产生一组多通拍位置; 将电描记图和设备识别的节拍位置存储在存储器位置中; 以及从存储器位置检索电描记图和设备标识的拍摄位置。 多遍处理确定心电图的至少第一个通道的位置。 然后将设备识别的拍摄位置组与使用多遍方法识别的拍摄位置的多通道组进行比较。 基于比较步骤，可以检测节拍过度，节拍不足或来自装置的噪音。

公开(公告)号：US20110077541A1

公开(公告)日：2011-03-31

申请号：US12879147

申请日：2010-09-10

申请人： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

发明人： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

IPC分类号： A61B5/04

CPC分类号： A61B5/04525 ,  G06K9/00536

摘要： A system and method for automatically analyzing a cardiac signal, including the step of providing an episode database on a computer storage medium including a plurality of episode data records of one or more patients. Each episode data record includes a cardiac signal from at least one data-generating device. The method also includes the step of selecting one or more of the N beats to be one or more beat templates, for at least a first cardiac signal having N beats. Another step is determining a value K for the cardiac signal using a computer system where K beat templates can represent all the N beats in the cardiac signal.

摘要翻译： 一种用于自动分析心脏信号的系统和方法，包括在包括一个或多个患者的多个发作数据记录的计算机存储介质上提供情节数据库的步骤。 每个剧集数据记录包括来自至少一个数据生成装置的心脏信号。 该方法还包括为至少具有N次拍子的第一个心脏信号选择N个节拍中的一个或多个作为一个或多个节拍模板的步骤。 另一步是使用计算机系统确定心脏信号的值K，其中K搏动模板可以表示心脏信号中的所有N个搏动。