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    Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists
    6.
    发明授权
    Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists 失效
    二取代的吗啉，氧氮杂或硫氮衍生物，其制备及其作为多巴胺d4受体拮抗剂的用途

    公开(公告)号：US06479491B1

    公开(公告)日：2002-11-12

    申请号：US09709297

    申请日：2000-11-13

    申请人： Oskar Axelsson ,  Dan Peters ,  Jorgen Scheel-Kruger ,  Elsebet Ostergaard Nielsen

    发明人： Oskar Axelsson ,  Dan Peters ,  Jorgen Scheel-Kruger ,  Elsebet Ostergaard Nielsen

    IPC分类号： A61K31535

    CPC分类号： C07D265/30 ,  C07D267/10 ,  C07D413/06

    摘要： The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R1, R2, R3, R4, R11, R12, R13, R14 and R15 each independently are hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, nitro, cyano, amino, acyl, alkylamino, dialkylamino, aminocarbonyl, or acylamino; R5 is hydrogen, alkyl, alkoxyalkyl, or phenylalkyl; X is —CH2—Z—, Z—CH2—, NH—CO—, —CO—NH—, or —CH═CH—; wherein Z is O, S, CH2, or NH; Y is O, —CH2—W—, —W—CH2—; wherein W is O, or S; and n is 0, 1 or 2. The compounds are useful in the treatment of psychotic disorders.

    摘要翻译： 本发明涉及式（I）化合物，其任何对映异构体或其任何混合物或其药学上可接受的酸加成盐，其中R 1，R 2，R 3，R 4，R 11，R 12，R 13，R 14和R 15各自 氰基，氨基，酰基，烷基氨基，二烷基氨基，氨基羰基或酰氨基; R5是氢，烷基，烷氧基烷基或苯基烷基; X是-CH 2 -Z-，Z-CH 2 - ，NH-CO - ， - CO-NH-或-CH = CH-; 其中Z是O，S，CH 2或NH; Y是O，-CH 2 -W-，-W-CH 2 - ; 其中W是O或S; 并且n为0,1或2.该化合物可用于治疗精神病。