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1.发明申请PROCESS FOR THE PREPARATON OF NOVEL PORPHYRIN DERIVATIVES AND THEIR USE AS PDT AGENTS AND FLUORESCENCE PROBES 有权新型吡啶衍生物的制备方法及其作为PDT剂和荧光探针的用途公开(公告)号：US20120308485A1
公开(公告)日：2012-12-06
申请号：US13574512
申请日：2011-01-21
申请人： Danaboyina Ramaiah , Suneesh C. Karunakaran , Jisha S. Vadakkancheril , Chandrashekar K. Tavarekere , Srinivasan Alagar , Madhavan Radhakrishna Pillai , Sivakumari Asha Nair , Saneesh Babu P. Saras , Mohan Chintalagiri Rao , Kunchala Sridhar Rao
发明人： Danaboyina Ramaiah , Suneesh C. Karunakaran , Jisha S. Vadakkancheril , Chandrashekar K. Tavarekere , Srinivasan Alagar , Madhavan Radhakrishna Pillai , Sivakumari Asha Nair , Saneesh Babu P. Saras , Mohan Chintalagiri Rao , Kunchala Sridhar Rao
IPC分类号： A61K49/00 , G01N21/76 , C07D487/22
CPC分类号： C07D487/22
摘要： The present invention provides novel porphyrin derivatives represented by the general formula 1 and/or pharmaceutically acceptable derivatives thereof as NIR sensitizers for photodynamic therapeutic and diagnostic, biological and industrial applications. These porphyrin derivatives posses absorption (400-700 nm) and emission (600-750 nm) in the regions where biological chromophores do not absorb and hence are ideal candidates for application as NIR PDT agents and fluorescence sensors for medicinal applications in biology. The substituents like hydroxyl and glycolic units on these dyes render them amphiphilicity thereby improving their solubility in the aqueous media and cellular uptake and localization. These dyes show no toxicity in the dark and are highly selective towards tumor cells and stain nucleus very rapidly. Accordingly, these porphyrin derivatives are extremely useful as NIR PDT fluorescence sensors in photodynamic therapeutic and diagnostic, biological and industrial applications.
摘要翻译： 本发明提供由通式1表示的新型卟啉衍生物和/或其药学上可接受的衍生物作为光动力学治疗和诊断，生物和工业应用的NIR敏化剂。 这些卟啉衍生物在生物发色团不吸收的区域中具有吸收（400-700nm）和发射（600-750nm），因此是用作生物学药物应用的NIR PDT试剂和荧光传感器的理想候选物。 这些染料上的取代基如羟基和乙醇酸单元使它们成为两亲性，从而提高它们在水性介质中的溶解度和细胞吸收和定位。 这些染料在黑暗中显示无毒性，对肿瘤细胞具有高度的选择性，并且非常迅速地染色细胞核。 因此，这些卟啉衍生物在光动力学治疗和诊断，生物和工业应用中作为NIR PDT荧光传感器非常有用。
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2.发明授权Process for the preparaton of novel porphyrin derivatives and their use as PDT agents and fluorescence probes 有权制备新型卟啉衍生物的方法及其作为PDT剂和荧光探针的用途公开(公告)号：US09040687B2
公开(公告)日：2015-05-26
申请号：US13574512
申请日：2011-01-21
申请人： Danaboyina Ramaiah , Suneesh C. Karunakaran , Jisha S. Vadakkancheril , Chandrashekar K. Tavarekere , Srinivasan Alagar , Madhavan Radhakrishna Pillai , Sivakumari Asha Nair , Saneesh Babu P. Saras , Mohan Chintalagiri Rao , Kunchala Sridhar Rao
发明人： Danaboyina Ramaiah , Suneesh C. Karunakaran , Jisha S. Vadakkancheril , Chandrashekar K. Tavarekere , Srinivasan Alagar , Madhavan Radhakrishna Pillai , Sivakumari Asha Nair , Saneesh Babu P. Saras , Mohan Chintalagiri Rao , Kunchala Sridhar Rao
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： The present invention provides novel porphyrin derivatives represented by the general formula 1 and/or pharmaceutically acceptable derivatives thereof as NIR sensitizers for photodynamic therapeutic and diagnostic, biological and industrial applications. These porphyrin derivatives possess absorption (400-700 nm) and emission (600-750 nm) in the regions where biological chromophores do not absorb and hence are ideal candidates for application as NIR PDT agents and fluorescence sensors for medicinal applications in biology. The substituents like hydroxyl and glycolic units on these dyes render them amphiphilicity thereby improving their solubility in the aqueous media and cellular uptake and localization. These dyes show no toxicity in the dark and are highly selective towards tumor cells and stain nucleus very rapidly. Accordingly, these porphyrin derivatives are extremely useful as NIR PDT fluorescence sensors in photodynamic therapeutic and diagnostic, biological and industrial applications.
摘要翻译： 本发明提供由通式1表示的新型卟啉衍生物和/或其药学上可接受的衍生物作为光动力学治疗和诊断，生物和工业应用的NIR敏化剂。 这些卟啉衍生物在生物发色团不吸收的区域中具有吸收（400-700nm）和发射（600-750nm），因此是用作NIR PDT试剂和用于生物学药物应用的荧光传感器的理想候选物。 这些染料上的取代基如羟基和乙醇酸单元使它们成为两亲性，从而提高它们在水性介质中的溶解度和细胞吸收和定位。 这些染料在黑暗中显示无毒性，对肿瘤细胞具有高度的选择性，并且非常迅速地染色细胞核。 因此，这些卟啉衍生物在光动力学治疗和诊断，生物和工业应用中作为NIR PDT荧光传感器非常有用。
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3.发明申请公开(公告)号：US20180299449A1
公开(公告)日：2018-10-18
申请号：US15481213
申请日：2017-04-06
申请人： Madhavan Radhakrishna Pillai , Mani Shankar Babu , Praveen Kunjan Sobhan , Anand Krishnan , Mahendra Seervi , Rakesh Sathish Nair
发明人： Madhavan Radhakrishna Pillai , Mani Shankar Babu , Praveen Kunjan Sobhan , Anand Krishnan , Mahendra Seervi , Rakesh Sathish Nair
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , C07D401/12 , C07D405/14 , G01N33/558 , G01N2333/82 , G01N2800/52
摘要： This document provides methods and materials for identifying individuals with protein tyrosine kinase associated disorders for responsiveness to a kinase inhibitor (e.g., imatinib or nilotinib). For example, methods and materials for using a chemi-immunochromatographic lateral flow strip for detection of BCR-ABL and drug resistance are provided.
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4.发明申请Mouthwash Composition for Managing Oral Mucositis, Process and Methods Thereof 审中-公开用于治疗口腔粘膜炎的漱口水组合物，其过程和方法公开(公告)号：US20130243702A1
公开(公告)日：2013-09-19
申请号：US13883551
申请日：2011-11-03
CPC分类号： A61K8/97 , A61K36/185 , A61K36/47 , A61K36/484 , A61K36/58 , A61Q11/00 , A61K2300/00
摘要： The present disclosure is in relation to a herbal cleansing composition comprising extracts from five plants namely Emblica officinalis, Terminalia chebula, Terminalia bellerica, Glycyrrhiza glabra and Azadiracta indica. Further, the present disclosure also relates to a process of obtaining said composition and applications thereof, wherein the composition is preferably used as an oral wash for delaying the onset of oral mucositis in cancer patients undergoing radiation treatment.
摘要翻译： 本公开涉及包含五种植物的提取物的草药清洁组合物，即五叶植物，枸杞，Terminalia cheerula，甘草，甘草和Azadiracta indica。 此外，本公开还涉及获得所述组合物及其应用的方法，其中所述组合物优选用作口服洗涤剂，用于延迟经历放射治疗的癌症患者的口腔粘膜炎的发作。
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