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公开(公告)号：US20130018051A1
公开(公告)日：2013-01-17
申请号：US13620010
申请日：2012-09-14
申请人： Rajinder Singh , Sacha Holland , Joane Litvak , Dane Goff , Jing Zhang , Thilo J. Heckrodt
发明人： Rajinder Singh , Sacha Holland , Joane Litvak , Dane Goff , Jing Zhang , Thilo J. Heckrodt
IPC分类号： C07D471/18 , A61K31/439 , C07D401/14 , A61K31/4545 , A61K31/4748 , A61K31/502 , C07D405/14 , C07D403/14 , A61K31/517 , A61K31/519 , C12P13/00 , C12P17/10 , A61P29/00 , A61P19/02 , A61P9/00 , A61P17/06 , A61P27/02 , A61P9/10 , A61P13/12 , A61P19/10 , A61P27/12 , A61P35/00 , A61P35/02 , A61P35/04 , A61K31/4709
CPC分类号： C07D403/04 , A61K31/502 , C07D221/22 , C07D237/26 , C07D237/34 , C07D401/14 , C07D403/14 , C07D471/18
摘要： Bridged bicyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
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公开(公告)号：US20110092502A1
公开(公告)日：2011-04-21
申请号：US12978260
申请日：2010-12-23
申请人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland
发明人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland
IPC分类号： A61K31/5377 , A61K31/517 , A61K31/4439 , A61K31/498 , A61K31/4725 , A61K31/428 , A61K31/519 , A61P15/00 , A61P35/00 , A61P29/00 , A61P19/00 , A61P27/02 , A61P17/06 , A61P13/12 , A61P9/00
CPC分类号： C07D417/04 , C07D495/04
摘要： Diaminothiazoles and pharmaceutical compositions containing them are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the diaminothiazoles in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译： 公开了含有它们的二氨基噻唑和药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。 还公开了使用二氨基噻唑治疗与Axl活性相关的疾病或病症的方法。
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3.发明授权公开(公告)号：US08658669B2
公开(公告)日：2014-02-25
申请号：US13620010
申请日：2012-09-14
申请人： Rajinder Singh , Sacha Holland , Joane Litvak , Dane Goff , Jing Zhang , Thilo J. Heckrodt
发明人： Rajinder Singh , Sacha Holland , Joane Litvak , Dane Goff , Jing Zhang , Thilo J. Heckrodt
CPC分类号： C07D403/04 , A61K31/502 , C07D221/22 , C07D237/26 , C07D237/34 , C07D401/14 , C07D403/14 , C07D471/18
摘要： Bridged bicyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译： 公开了桥连双环杂芳基取代的三唑和含有这些化合物的药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。 还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。
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4.发明授权公开(公告)号：US08168636B2
公开(公告)日：2012-05-01
申请号：US12986951
申请日：2011-01-07
申请人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak
发明人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak
IPC分类号： A61K31/502 , C07D237/26
CPC分类号： C07D401/14 , A61K31/502 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/20 , C07D495/04 , C07D519/00
摘要： Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译： 公开了多环杂芳基取代的三唑和含有这些化合物的药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。 还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。
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5.发明申请BRIDGED BICYCLIC ARYL AND BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权桥双环芳基和桥双环杂芳基取代三唑有用AS AXL抑制剂公开(公告)号：US20110281846A1
公开(公告)日：2011-11-17
申请号：US13191252
申请日：2011-07-26
申请人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Pingyu Ding , Joane Litvak
发明人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Pingyu Ding , Joane Litvak
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/502 , A61K31/497 , A61K31/496 , A61K31/519 , A61K31/439 , A61P35/02 , A61P19/02 , A61P17/06 , A61P27/02 , A61P3/10 , A61P13/12 , A61P19/10 , A61P9/00 , A61P27/12 , A61P35/00 , A61K31/5513
CPC分类号： C07D495/04 , C07D249/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D409/14 , C07D453/06 , C07D471/18
摘要： Bridged bicyclic aryl or heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译： 公开了桥连双环芳基或杂芳基取代的三唑和含有这些化合物的药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。 还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。
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公开(公告)号：US20110098274A1
公开(公告)日：2011-04-28
申请号：US12986951
申请日：2011-01-07
申请人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak
发明人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak
IPC分类号： A61K31/55 , C07D249/14 , C07D237/26 , C07D223/18 , C07D285/36 , A61K31/4196 , A61K31/502 , A61P35/00
CPC分类号： C07D401/14 , A61K31/502 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/20 , C07D495/04 , C07D519/00
摘要： Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
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7.发明申请BICYCLIC ARYL AND BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权双相ARYL和双相异构体取代三唑类有用的AXL抑制剂公开(公告)号：US20110071133A1
公开(公告)日：2011-03-24
申请号：US12957822
申请日：2010-12-01
申请人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Pingyu Ding , Thilo J. Heckrodt , Joane Litvak
发明人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Pingyu Ding , Thilo J. Heckrodt , Joane Litvak
IPC分类号： A61K31/551 , A61K31/502 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/55 , A61P29/00 , A61P9/00 , A61P17/06 , A61P19/10 , A61P35/00 , A61P13/12
CPC分类号： A61K31/519 , A61K31/395 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/14 , C07D495/04
摘要： Bicyclic aryl substituted triazoles or heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译： 公开了双环芳基取代的三唑或杂芳基取代的三唑和含有这些化合物的药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。 还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。
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公开(公告)号：US20080227789A1
公开(公告)日：2008-09-18
申请号：US11963157
申请日：2007-12-21
申请人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland
发明人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland
IPC分类号： A61K31/426 , C07D403/04 , C07D277/00 , A61K31/517 , A61K31/498 , A61P19/02 , A61P9/00 , A61P27/02 , A61P13/12 , A61P19/10 , A61P27/12 , A61P35/00 , A61P35/02 , A61P27/06 , A61P3/10
CPC分类号： C07D417/04 , C07D495/04
摘要： Diaminothiazoles and pharmaceutical compositions containing them are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the diaminothiazoles in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译： 公开了含有它们的二氨基噻唑和药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。 还公开了使用二氨基噻唑治疗与Axl活性相关的疾病或病症的方法。
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公开(公告)号：US20080188455A1
公开(公告)日：2008-08-07
申请号：US11967172
申请日：2007-12-29
申请人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak
发明人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak
IPC分类号： A61K31/4355 , C07D249/14 , C07D491/113 , A61K31/554 , A61P19/02 , A61P35/02 , A61P35/00 , A61P17/06 , C07D285/36 , A61K31/4196
CPC分类号： C07D401/14 , A61K31/502 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/20 , C07D495/04 , C07D519/00
摘要： Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译： 公开了多环杂芳基取代的三唑和含有这些化合物的药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。 还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。
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10.发明申请BICYCLIC ARYL AND BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权双相ARYL和双相异构体取代三唑类有用的AXL抑制剂公开(公告)号：US20080188454A1
公开(公告)日：2008-08-07
申请号：US11966585
申请日：2007-12-28
申请人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Pingyu Ding , Thilo J. Heckrodt , Joane Litvak
发明人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Pingyu Ding , Thilo J. Heckrodt , Joane Litvak
IPC分类号： A61K31/496 , C07D239/70 , A61K31/55 , A61P35/00 , A61P35/02 , A61K31/397 , C07D403/14
CPC分类号： A61K31/519 , A61K31/395 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/14 , C07D495/04
摘要： Bicyclic aryl substituted triazoles or heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译： 公开了双环芳基取代的三唑或杂芳基取代的三唑和含有这些化合物的药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。 还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。
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