公开(公告)号：US20070148089A1

公开(公告)日：2007-06-28

申请号：US11542758

申请日：2006-10-03

申请人： Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Daniel Afar ,  Steven Mitchell ,  Mary Faris ,  Aya Jakobovits

发明人： Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Daniel Afar ,  Steven Mitchell ,  Mary Faris ,  Aya Jakobovits

IPC分类号： A61K51/00 ,  G01N33/574 ,  A01K67/027 ,  C12P21/06 ,  A61K39/395 ,  C07K14/82 ,  C07K16/30 ,  C07K16/46

CPC分类号： C07K16/3069 ,  A61K38/00 ,  A61K39/00 ,  A61K51/1072 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2333/705

摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两个蛋白质完全或主要地在前列腺中表达，也包括在前列腺癌中，因此该家族成员被称为“STEAP”（前列腺的六跨膜上皮抗原）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

公开(公告)号：US20050004349A1

公开(公告)日：2005-01-06

申请号：US10753195

申请日：2004-01-06

申请人： Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Daniel Afar ,  Steven Mitchell ,  Mary Faris ,  Aya Jakobovits

发明人： Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Daniel Afar ,  Steven Mitchell ,  Mary Faris ,  Aya Jakobovits

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/705 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/395 ,  C07H21/04

CPC分类号： C07K16/3069 ,  A61K38/00 ,  A61K39/00 ,  A61K51/1072 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2333/705

摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两个蛋白质完全或主要地在前列腺中表达，也包括在前列腺癌中，因此该家族成员被称为“STEAP”（前列腺的六跨膜上皮抗原）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

公开(公告)号：US20060020113A9

公开(公告)日：2006-01-26

申请号：US10753195

申请日：2004-01-06

申请人： Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Daniel Afar ,  Steven Mitchell ,  Mary Faris ,  Aya Jakobovits

发明人： Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Daniel Afar ,  Steven Mitchell ,  Mary Faris ,  Aya Jakobovits

IPC分类号： A61K39/395 ,  C07K14/705 ,  C07H21/04

CPC分类号： C07K16/3069 ,  A61K38/00 ,  A61K39/00 ,  A61K51/1072 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2333/705

摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

公开(公告)号：US20050214211A1

公开(公告)日：2005-09-29

申请号：US11073349

申请日：2005-03-03

申请人： Pia Challita-Eid ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Steven Mitchell ,  Daniel Afar ,  Douglas Saffran ,  Karen Morrison ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

发明人： Pia Challita-Eid ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Steven Mitchell ,  Daniel Afar ,  Douglas Saffran ,  Karen Morrison ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

IPC分类号： A01K67/027 ,  A61K39/395 ,  A61K51/00 ,  C07K14/47 ,  C07K16/40 ,  C12N5/06

CPC分类号： C07K14/47

摘要： A novel gene (designated 121P2A3) and its encoded protein, and variants thereof, are described wherein 121P2A3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P2A3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121P2A3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 121P2A3 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因（命名为121P2A3）及其编码的蛋白质及其变体，其中121P2A3在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，121P2A3提供诊断，预后， 癌症的预防和/或治疗靶标。 121P2A3基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与121P2A3反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20120076724A9

公开(公告)日：2012-03-29

申请号：US11542758

申请日：2006-10-03

申请人： Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Daniel Afar ,  Steven Mitchell ,  Mary Faris ,  Aya Jakobovits

发明人： Rene Hubert ,  Arthur Raitano ,  Douglas Saffran ,  Daniel Afar ,  Steven Mitchell ,  Mary Faris ,  Aya Jakobovits

IPC分类号： A61K51/00 ,  A01K67/027 ,  C07K16/46 ,  A61K39/395 ,  C07K14/82 ,  C07K16/30 ,  G01N33/574 ,  C12P21/06

CPC分类号： C07K16/3069 ,  A61K38/00 ,  A61K39/00 ,  A61K51/1072 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2333/705

摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 该家族中的两个蛋白质完全或主要地在前列腺中表达，也包括在前列腺癌中，因此该家族成员被称为“STEAP”（前列腺的六跨膜上皮抗原）。 本文描述和表征了四种特定的人STEAP。 人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STEAP-1在某些其他人类癌症中高度过度表达。

公开(公告)号：US20050074807A1

公开(公告)日：2005-04-07

申请号：US10959697

申请日：2004-10-05

申请人： Daniel Afar ,  Arthur Raitano ,  Rene Hubert ,  Steven Mitchell ,  Aya Jakobovits

发明人： Daniel Afar ,  Arthur Raitano ,  Rene Hubert ,  Steven Mitchell ,  Aya Jakobovits

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C07K14/705

CPC分类号： C07K14/47 ,  A61K38/00 ,  C12N2799/026 ,  Y02A50/465 ,  Y02A50/473

摘要： The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogeneous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 bp 20P2H8 cDNA (SEQ ID NO: 1, encoding a 517 amino acid open reading frame (SEQ ID NO: 2), is provided herein.

摘要翻译： 本发明涉及一种与几种异质核核糖核蛋白（hnRNPs）具有同源性的命名为20P2H8的新型蛋白质。 本文提供了全长约3600bp的20P2H8 cDNA（SEQ ID NO：1，编码517个氨基酸的开放阅读框（SEQ ID NO：2））。

公开(公告)号：US08389881B2

公开(公告)日：2013-03-05

申请号：US13470230

申请日：2012-05-11

申请人： Owen Gregory ,  Edward O'Sullivan ,  Sherif Kamel ,  Steven Mitchell

发明人： Owen Gregory ,  Edward O'Sullivan ,  Sherif Kamel ,  Steven Mitchell

IPC分类号： H01R25/14

CPC分类号： H01H31/02 ,  H01H11/00 ,  H01H31/00 ,  H01H31/28 ,  H01R4/489 ,  H01R4/50 ,  H01R25/14 ,  H01R43/00

摘要： A conductor termination system for use with an electrical power transmission conductor includes a termination assembly and a connector. The termination assembly includes an end member and an integral retainer mechanism. The end member includes a receiver portion configured to receive a segment of the conductor. The retainer mechanism includes a moveable keeper member on the end member. The retainer mechanism is operable to selectively clamp a segment of the conductor in the receiver portion to the end member and to apply a retention load to the conductor segment. The connector is adapted to be applied to the end member and the conductor to securely clamp the conductor segment to the end member.

摘要翻译： 用于电力传输导体的导体终端系统包括终端组件和连接器。 终端组件包括端部构件和整体保持器机构。 端部构件包括被配置为接收导体的段的接收器部分。 保持器机构包括端部构件上的可移动保持构件。 保持器机构可操作地选择性地将接收器部分中的导体的一段夹持到端部构件并且向导体段施加保持负载。 连接器适于施加到端部构件和导体，以将导体段牢固地夹持到端部构件。

公开(公告)号：US08198558B2

公开(公告)日：2012-06-12

申请号：US12482921

申请日：2009-06-11

申请人： Owen Gregory ,  Edward O'Sullivan ,  Sherif Kamel ,  Steven Mitchell

发明人： Owen Gregory ,  Edward O'Sullivan ,  Sherif Kamel ,  Steven Mitchell

IPC分类号： H01R25/14

CPC分类号： H01H31/02 ,  H01H11/00 ,  H01H31/00 ,  H01H31/28 ,  H01R4/489 ,  H01R4/50 ,  H01R25/14 ,  H01R43/00

摘要： A conductor termination system for use with an electrical power transmission conductor includes a termination assembly and a connector. The termination assembly includes an end member and an integral retainer mechanism. The end member includes a receiver portion configured to receive a segment of the conductor. The retainer mechanism includes a moveable keeper member on the end member. The retainer mechanism is operable to selectively clamp a segment of the conductor in the receiver portion to the end member and to apply a retention load to the conductor segment. The connector is adapted to be applied to the end member and the conductor to securely clamp the conductor segment to the end member.

摘要翻译： 用于电力传输导体的导体终端系统包括终端组件和连接器。 终端组件包括端部构件和整体保持器机构。 端部构件包括被配置为接收导体的段的接收器部分。 保持器机构包括端部构件上的可移动保持构件。 保持器机构可操作地选择性地将接收器部分中的导体的一段夹持到端部构件并且向导体段施加保持负载。 连接器适于施加到端部构件和导体，以将导体段牢固地夹持到端部构件。

公开(公告)号：US20080086212A1

公开(公告)日：2008-04-10

申请号：US11788763

申请日：2007-04-19

申请人： James Zucherman ,  Ken Hsu ,  Charles Winslow ,  Henry Klyce ,  Scott Yerby ,  John Flynn ,  Steven Mitchell ,  John Markwart

发明人： James Zucherman ,  Ken Hsu ,  Charles Winslow ,  Henry Klyce ,  Scott Yerby ,  John Flynn ,  Steven Mitchell ,  John Markwart

IPC分类号： A61F2/44 ,  A61B17/58

CPC分类号： A61B17/7068 ,  A61B17/66 ,  A61B17/7065 ,  A61B17/7071 ,  A61B2017/00557 ,  A61K31/37

摘要： A spine distraction implant alleviates pain associated with spinal stenosis and facet arthropathy by expanding the volume in the spine canal and/or neural foramen. The implant provides a spinal extension stop while allowing freedom of spinal flexion. An interspinous process implant with a selectably expandable spacer can be placed between adjacent spinous processes. a device implanted between the spinous processes of adjacent vertebrae of the spine can be used for relieving pain associated with the vertebrae and surrounding tissues and structures by maintaining and/or adding distraction between adjacent vertebrae. A tissue expander can be adapted to move from a first insertion position, for ease of implantation between spinous processes, to a second retention position that prevents displacement of the implant. An embodiment of a system can include an implant having a spacer with a thickness and a wing, wherein a first configuration of the wing has a first height substantially similar to the thickness and wherein the wing is adapted to be selectably arranged in a second configuration such that the wing has a second height greater than the first height. A periphery of the implant has a shape generally conformal with a shape of an inner surface of a cannula and a cross-sectional diameter smaller than an inner diameter of the cannula. The cannula is inserted such that a proximal end of the cannula is arranged between the adjacent spinous processes. The implant is then urged into position between the adjacent spinous processes by way of the cannula, and subsequently arranged in a second configuration to fix the implant in position.

摘要翻译： 脊柱分心植入物通过扩大脊柱管和/或神经孔的体积来减轻与脊柱狭窄和小关节病相关的疼痛。 植入物提供脊椎伸展停止，同时允许脊柱屈曲的自由。 具有可选择地可扩展间隔物的椎间植入植入物可以放置在相邻的棘突之间。 植入脊椎相邻椎骨的棘突之间的装置可用于通过维持和/或增加相邻椎骨之间的牵引来减轻与椎骨和周围组织和结构相关的疼痛。 组织扩张器可以适于从第一插入位置移动，以便于在棘突之间植入到防止植入物移位的第二保持位置。 系统的实施例可以包括具有厚度和翼的间隔件的植入物，其中所述翼的第一构造具有与所述厚度基本相似的第一高度，并且其中所述翼适于可选地布置成第二构型 机翼的第二高度大于第一高度。 植入物的周边具有与插管的内表面的形状大致一致的形状，并且截面直径小于插管的内径。 套管被插入使得插管的近端布置在相邻的棘突之间。 然后通过插管将植入物推动到相邻棘突之间的位置，并且随后被布置成第二构造以将植入物固定就位。

公开(公告)号：US20070276500A1

公开(公告)日：2007-11-29

申请号：US11668217

申请日：2007-01-29

申请人： James Zucherman ,  Ken Hsu ,  Henry Klyce ,  Charles Winslow ,  John Flynn ,  Steven Mitchell ,  Scott Yerby ,  John Markwart

发明人： James Zucherman ,  Ken Hsu ,  Henry Klyce ,  Charles Winslow ,  John Flynn ,  Steven Mitchell ,  Scott Yerby ,  John Markwart

IPC分类号： A61F2/44

CPC分类号： A61B17/7068 ,  A61B17/7053 ,  A61B2017/00867

摘要： Systems in accordance with embodiments of the present invention can include an implant comprising a spacer for defining a minimum space between adjacent spinous processes, a distraction guide for piercing and distracting an interspinous ligament during implantation, and a binder for limiting or preventing flexion motion of the targeted motion segment. The binder can be secured to a brace associated with the implant during implantation by a capture device. A binder aligner aligns the binder with the implant stabilizing the implant, binder and the adjacent vertebrae.

摘要翻译： 根据本发明的实施例的系统可以包括植入物，其包括用于限定相邻棘突之间的最小空间的间隔件，用于在植入期间刺穿和分散椎间韧带的牵引引导件，以及用于限制或防止植入物中的屈曲运动的粘合剂 目标运动部分。 在通过捕获装置植入期间，粘合剂可以固定到与植入物相关联的支架上。 粘合剂对准器将粘合剂与固定植入物，粘合剂和相邻椎骨的植入物对准。