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公开(公告)号：US11370839B2
公开(公告)日：2022-06-28
申请号：US16342582
申请日：2017-11-10
申请人： Daniel Cua , Holly Cherwinski , Adele Wang , Yi Chen , Barbara Joyce-Shaikh , Merck Sharp & Dohme Corp.
发明人： Daniel Cua , Holly Cherwinski , Adele Wang , Yi Chen , Barbara Joyce-Shaikh
IPC分类号： C07K16/28 , A61P35/00 , G01N33/542 , A61K39/00
摘要： The present invention provides antibodies and antigen-binding fragments thereof that bind ILT3, ILT3 ligand (i.e., PI16) or a complex between ILT3 and the ILT3 ligand. Methods for determining whether ILT3 and the ILT3 ligand bind together or whether a substance agonizes or antagonizes such binding are also provided.
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公开(公告)号：US20190241655A1
公开(公告)日：2019-08-08
申请号：US16342582
申请日：2017-11-06
申请人： Daniel CUA , Holly CHERWINSKI , Adele WANG , Yi CHEN , Barbara JOYCE-SHAIKH , Merck Sharp & Dohme Corp.
发明人： Daniel Cua , Holly Cherwinski , Adele Wang , Yi Chen , Barbara Joyce-Shaikh
IPC分类号： C07K16/28 , G01N33/542 , A61P35/00
CPC分类号： C07K16/2803 , A61K2039/505 , A61P35/00 , C07K2317/32 , C07K2317/76 , G01N33/542
摘要： The present invention provides antibodies and antigen-binding fragments thereof that bind ILT3, ILT3 ligand (i.e., PI16) or a complex between ILT3 and the ILT3 ligand. Methods for determining whether ILT3 and the ILT3 ligand bind together or whether a substance agonizes or antagonizes such binding are also provided.
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公开(公告)号：US11053315B2
公开(公告)日：2021-07-06
申请号：US15945779
申请日：2018-04-05
发明人： Barbara Joyce-Shaikh , Luis A. Zuniga , Milan Blanusa , Andrea Claudia Schuster , Kornelia Schultze
摘要： The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof, e.g., with an anti-PD1 antibody. Also provided are methods of use thereof, for example, for treating or preventing cancer in a subject; and methods of making such antibodies and fragments.
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公开(公告)号：US20140227719A1
公开(公告)日：2014-08-14
申请号：US14346202
申请日：2012-09-17
发明人： Barbara Joyce-Shaikh , Douglas C. Wilson , Daniel J. Cua , Drake M. LaFace , Marbel Beaumont , Holly Cherwinski , Mark Hsieh , Sabrina Benchaar , Joseph H. Philips
IPC分类号： G01N33/50
CPC分类号： C07K16/2851 , A61K2039/505 , C07K14/7056 , C07K2317/76 , C07K2319/00 , G01N33/5008 , G01N33/5041 , G01N33/505 , G01N33/56972 , G01N2333/4724 , G01N2440/14 , G01N2500/02 , G01N2500/10
摘要： The invention provides methods for modulation interactions between MDL-1 and its binding partner, Gal9. Also provided are methods to screen for modulators of MDL-1/Gal9 interaction.
摘要翻译： 本发明提供了MDL-1与其结合配偶体Gal9之间调节相互作用的方法。 还提供了筛选MDL-1 / Gal9相互作用的调节剂的方法。
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公开(公告)号：US09284377B2
公开(公告)日：2016-03-15
申请号：US14744706
申请日：2015-06-19
发明人： Barbara Joyce-Shaikh , Douglas C. Wilson , Daniel J. Cua , Drake M. LaFace , Joseph H. Phillips
IPC分类号： C07K16/28 , G01N33/50 , C07K14/705 , A61K39/00
CPC分类号： C07K16/2851 , A61K2039/505 , C07K14/7056 , C07K2317/76 , C07K2319/00 , G01N33/5008 , G01N33/5041 , G01N33/505 , G01N33/56972 , G01N2333/4724 , G01N2440/14 , G01N2500/02 , G01N2500/10
摘要： The invention provides methods for modulation interactions between MDL-1 and its binding partner, Gal9. Also provided are methods to screen for modulators of MDL-1/Gal9 interaction.
摘要翻译： 本发明提供了MDL-1与其结合配偶体Gal9之间调节相互作用的方法。 还提供了筛选MDL-1 / Gal9相互作用的调节剂的方法。
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公开(公告)号：US20150368344A1
公开(公告)日：2015-12-24
申请号：US14744706
申请日：2015-06-19
发明人： Barbara Joyce-Shaikh , Douglas C. Wilson , Daniel J. Cua , Drake M. LaFace , Maribel Beaumont , Holly Cherwinski , Mark Hsieh , Sabrina Benchaar , Joseph H. Phillips
IPC分类号： C07K16/28 , C07K14/705 , G01N33/50
CPC分类号： C07K16/2851 , A61K2039/505 , C07K14/7056 , C07K2317/76 , C07K2319/00 , G01N33/5008 , G01N33/5041 , G01N33/505 , G01N33/56972 , G01N2333/4724 , G01N2440/14 , G01N2500/02 , G01N2500/10
摘要： The invention provides methods for modulation interactions between MDL-1 and its binding partner, Gal9. Also provided are methods to screen for modulators of MDL-1/Gal9 interaction.
摘要翻译： 本发明提供了MDL-1与其结合配偶体Gal9之间调节相互作用的方法。 还提供了筛选MDL-1 / Gal9相互作用的调节剂的方法。
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公开(公告)号：US20220002403A1
公开(公告)日：2022-01-06
申请号：US17338566
申请日：2021-06-03
发明人： Milan Blanusa , Barbara Joyce-Shaikh , Andrea Claudia Schuster , Kornelia Schultze , Luis A. Zuniga
摘要： The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof, e.g., with an anti-PD1 antibody. Also provided are methods of use thereof, for example, for treating or preventing cancer in a subject; and methods of making such antibodies and fragments.
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公开(公告)号：US20180298096A1
公开(公告)日：2018-10-18
申请号：US15945779
申请日：2018-04-05
发明人： Barbara Joyce-Shaikh , Luis A. Zuniga , Milan Blanusa , Andrea Claudia Schuster , Kornelia Schultze
摘要： The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof, e.g., with an anti-PD1 antibody. Also provided are methods of use thereof, for example, for treating or preventing cancer in a subject; and methods of making such antibodies and fragments.
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公开(公告)号：US20140234301A1
公开(公告)日：2014-08-21
申请号：US14181488
申请日：2014-02-14
CPC分类号： C07K16/28 , A61K31/713 , A61K38/177 , C07K16/2803 , C07K2317/33 , C07K2317/75 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C12N15/1138 , C12N2310/11 , C12N2310/14
摘要： The present invention provides methods of using PILRα agonists, or PILRβ antagonists, to treat immune disorders, such as autoimmune and inflammatory disorders, including CNS, joint and gut inflammation.
摘要翻译： 本发明提供使用PILRα激动剂或PILR＆bgr的方法。 拮抗剂，用于治疗免疫疾病，例如自身免疫和炎性疾病，包括CNS，关节和肠道炎症。
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公开(公告)号：US20130071380A1
公开(公告)日：2013-03-21
申请号：US13516635
申请日：2010-12-10
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/28 , A61K31/713 , A61K38/177 , C07K16/2803 , C07K2317/33 , C07K2317/75 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C12N15/1138 , C12N2310/11 , C12N2310/14
摘要： The present invention provides methods of using PILRα agonists, or PILRβ antagonists, to treat immune disorders, such as autoimmune and inflammatory disorders, including CNS, joint and gut inflammation.
摘要翻译： 本发明提供使用PILRα激动剂或PILR＆bgr的方法。 拮抗剂，用于治疗免疫疾病，例如自身免疫和炎性疾病，包括CNS，关节和肠道炎症。
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