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公开(公告)号:US11370839B2
公开(公告)日:2022-06-28
申请号:US16342582
申请日:2017-11-10
申请人: Daniel Cua , Holly Cherwinski , Adele Wang , Yi Chen , Barbara Joyce-Shaikh , Merck Sharp & Dohme Corp.
发明人: Daniel Cua , Holly Cherwinski , Adele Wang , Yi Chen , Barbara Joyce-Shaikh
IPC分类号: C07K16/28 , A61P35/00 , G01N33/542 , A61K39/00
摘要: The present invention provides antibodies and antigen-binding fragments thereof that bind ILT3, ILT3 ligand (i.e., PI16) or a complex between ILT3 and the ILT3 ligand. Methods for determining whether ILT3 and the ILT3 ligand bind together or whether a substance agonizes or antagonizes such binding are also provided.
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公开(公告)号:US20190241655A1
公开(公告)日:2019-08-08
申请号:US16342582
申请日:2017-11-06
申请人: Daniel CUA , Holly CHERWINSKI , Adele WANG , Yi CHEN , Barbara JOYCE-SHAIKH , Merck Sharp & Dohme Corp.
发明人: Daniel Cua , Holly Cherwinski , Adele Wang , Yi Chen , Barbara Joyce-Shaikh
IPC分类号: C07K16/28 , G01N33/542 , A61P35/00
CPC分类号: C07K16/2803 , A61K2039/505 , A61P35/00 , C07K2317/32 , C07K2317/76 , G01N33/542
摘要: The present invention provides antibodies and antigen-binding fragments thereof that bind ILT3, ILT3 ligand (i.e., PI16) or a complex between ILT3 and the ILT3 ligand. Methods for determining whether ILT3 and the ILT3 ligand bind together or whether a substance agonizes or antagonizes such binding are also provided.
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公开(公告)号:US20060140950A1
公开(公告)日:2006-06-29
申请号:US11359269
申请日:2006-02-21
申请人: Daniel Cua , Yi Chen , Robert Kastelein , Claire Langrish , Donna Rennick , Jonathon Sedgwick
发明人: Daniel Cua , Yi Chen , Robert Kastelein , Claire Langrish , Donna Rennick , Jonathon Sedgwick
IPC分类号: A61K48/00 , A61K38/17 , A61K39/395
摘要: Provided are methods of treatment for inflammatory and autoimmune disorders of the central nervous system and gastrointestinal tract. Also provided are methods of diagnosis.
摘要翻译: 提供了治疗中枢神经系统和胃肠道的炎性和自身免疫性疾病的方法。 还提供诊断方法。
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公开(公告)号:US20140286946A1
公开(公告)日:2014-09-25
申请号:US14354931
申请日:2012-10-26
发明人: Terrance A. Stadheim , Daniel Cua , Dongxing Zha
CPC分类号: C07K16/2878 , C07K16/00 , C07K16/241 , C07K2317/41 , C07K2317/52 , C07K2317/72
摘要: The present invention is directed to methods and compositions for the production of Fc-containing polypeptides having improved properties.
摘要翻译: 本发明涉及用于生产具有改进性质的含Fc多肽的方法和组合物。
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公开(公告)号:US20060134112A1
公开(公告)日:2006-06-22
申请号:US11305748
申请日:2005-12-16
申请人: Daniel Cua , Robert Kastelein
发明人: Daniel Cua , Robert Kastelein
IPC分类号: A61K48/00 , A61K39/395 , A61K38/17
CPC分类号: C07K16/244 , A61K31/52 , A61K31/573 , A61K38/13 , A61K38/1793 , A61K45/06 , A61K2039/505 , C07K14/54 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/14 , Y10S514/866 , A61K2300/00
摘要: Provided are methods of treatment for inflammatory and autoimmune disorders of the metabolic system. Also provided are methods of diagnosis.
摘要翻译: 提供了代谢系统的炎性和自身免疫性疾病的治疗方法。 还提供诊断方法。
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公开(公告)号:US20050208052A1
公开(公告)日:2005-09-22
申请号:US11059114
申请日:2005-02-15
申请人: Peter Katsikis , Ioannis Dimitriou , Daniel Cua
发明人: Peter Katsikis , Ioannis Dimitriou , Daniel Cua
IPC分类号: A61K31/7088 , A61K38/17 , A61K38/20 , A61K39/395 , A61K48/00 , C07K14/54 , G01N33/569 , G01N33/68
CPC分类号: C07K14/54 , A01K67/0276 , A01K2207/20 , A01K2217/056 , A01K2227/105 , A01K2267/0337 , A61K31/7088 , A61K38/1793 , A61K38/20 , A61K38/208 , A61K39/3955 , G01N33/56983 , G01N33/6869 , G01N2333/11 , G01N2500/00 , G01N2800/26 , A61K2300/00
摘要: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating viral infections. Also provided are reagents for use in screening for agonists or antagonists of IL-23.
摘要翻译: 提供了调节细胞因子活性的方法,例如用于治疗病毒感染的目的。 还提供了用于筛选IL-23的激动剂或拮抗剂的试剂。
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