公开(公告)号：US20140315760A1

公开(公告)日：2014-10-23

申请号：US14234134

申请日：2012-07-20

申请人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/543 ,  G01N33/80

CPC分类号： G01N33/54373 ,  G01N21/75 ,  G01N33/80

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

摘要翻译： 提供了用于检测生物溶液（例如全血）中的分析物的光子器件，系统和方法。 代表性的光子器件是具有纳米尺度特征和微米尺寸直径的光学环形谐振器。 由于这些器件的紧凑尺寸，许多谐振器可以被布置在单个衬底上并且当样品通过器件时同时测试。 典型的分析物包括血细胞，抗体和病原体，以及指示存在血细胞或病原体的化合物（例如血清学）。 在某些实施方案中，血液类型可以通过使用血细胞直接检测和血清学的组合的光子感测来确定。 通过组合多个装置的检测信号，可以确定血液的类型。

公开(公告)号：US09599613B2

公开(公告)日：2017-03-21

申请号：US14234134

申请日：2012-07-20

申请人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/80 ,  G01N33/543 ,  G01N21/75

CPC分类号： G01N33/54373 ,  G01N21/75 ,  G01N33/80

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.