PHOTONIC BLOOD TYPING
    1.
    发明申请

    公开(公告)号:US20140315760A1

    公开(公告)日:2014-10-23

    申请号:US14234134

    申请日:2012-07-20

    IPC分类号: G01N33/543 G01N33/80

    摘要: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

    摘要翻译: 提供了用于检测生物溶液(例如全血)中的分析物的光子器件,系统和方法。 代表性的光子器件是具有纳米尺度特征和微米尺寸直径的光学环形谐振器。 由于这些器件的紧凑尺寸,许多谐振器可以被布置在单个衬底上并且当样品通过器件时同时测试。 典型的分析物包括血细胞,抗体和病原体,以及指示存在血细胞或病原体的化合物(例如血清学)。 在某些实施方案中,血液类型可以通过使用血细胞直接检测和血清学的组合的光子感测来确定。 通过组合多个装置的检测信号,可以确定血液的类型。

    DUAL-FUNCTIONAL NONFOULING SURFACES AND MATERIALS
    7.
    发明申请
    DUAL-FUNCTIONAL NONFOULING SURFACES AND MATERIALS 有权
    双功能非金属表面和材料

    公开(公告)号:US20100099160A1

    公开(公告)日:2010-04-22

    申请号:US12493649

    申请日:2009-06-29

    摘要: Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery.

    摘要翻译: 双功能非结垢表面和材料,用于制造双功能非结垢表面和材料的方法,以及包括双功能非结垢表面和材料的装置。 双功能表面是抵抗非特异性蛋白质吸附和细胞粘附的非结垢表面。 双功能表面和材料包括向其赋予特定生物活性的共价偶联的生物分子(例如靶结合配偶体)。 表面和材料可用于医学诊断,生物材料和生物处理,组织工程和药物递送。