公开(公告)号：US09599613B2

公开(公告)日：2017-03-21

申请号：US14234134

申请日：2012-07-20

申请人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/80 ,  G01N33/543 ,  G01N21/75

CPC分类号： G01N33/54373 ,  G01N21/75 ,  G01N33/80

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

公开(公告)号：US08236993B2

公开(公告)日：2012-08-07

申请号：US12524603

申请日：2008-01-25

申请人： José A. López Más ,  Sergio A. Streitenberger ,  Marcos Peñalver Mellado ,  Pedro Martinez Ortiz

发明人： José A. López Más ,  Sergio A. Streitenberger ,  Marcos Peñalver Mellado ,  Pedro Martinez Ortiz

IPC分类号： C07C37/68 ,  A23L1/00

CPC分类号： B01J19/18 ,  B01J2219/00006 ,  B01J2219/00094 ,  C07C37/004 ,  C07C39/11

摘要： Hydroxytyrosol is extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by carrying out acid hydrolysis at a temperature within the range of 110° C. to 140° C. and at a pH within the range of 1.0 to 6.0, and by purifying the obtained solution on a column containing acid activated anion exchange resins, and a column containing an adsorbent non-ionic resin; both columns being eluted with water to recover the hydroxytyrosol.

摘要翻译： 提取橄榄油后，从橄榄和/或橄榄的固体残渣中提取羟基酪蛋白，通过在110℃至140℃的温度范围内进行酸水解，并在pH范围内 1.0至6.0，并将所得溶液纯化在含有酸活化阴离子交换树脂的柱和含有吸附剂非离子树脂的柱上; 两个柱用水洗脱以回收羟基酪醇。

公开(公告)号：US20140315760A1

公开(公告)日：2014-10-23

申请号：US14234134

申请日：2012-07-20

申请人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/543 ,  G01N33/80

CPC分类号： G01N33/54373 ,  G01N21/75 ,  G01N33/80

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

摘要翻译： 提供了用于检测生物溶液（例如全血）中的分析物的光子器件，系统和方法。 代表性的光子器件是具有纳米尺度特征和微米尺寸直径的光学环形谐振器。 由于这些器件的紧凑尺寸，许多谐振器可以被布置在单个衬底上并且当样品通过器件时同时测试。 典型的分析物包括血细胞，抗体和病原体，以及指示存在血细胞或病原体的化合物（例如血清学）。 在某些实施方案中，血液类型可以通过使用血细胞直接检测和血清学的组合的光子感测来确定。 通过组合多个装置的检测信号，可以确定血液的类型。

公开(公告)号：US20120269790A1

公开(公告)日：2012-10-25

申请号：US13428621

申请日：2012-03-23

申请人： Marcos PEÑALVER MELLADO ,  José A. LÓPEZ MAS ,  Sergio A. STREITENBERGER ,  Pedro MARTINEZ ORTIZ

发明人： Marcos PEÑALVER MELLADO ,  José A. LÓPEZ MAS ,  Sergio A. STREITENBERGER ,  Pedro MARTINEZ ORTIZ

IPC分类号： A61K36/185 ,  A61K35/74 ,  A61P1/00 ,  A61P9/10 ,  A61P35/00 ,  A61P3/10 ,  A61P3/04 ,  A61K36/87 ,  A61P9/00

CPC分类号： A23L2/52 ,  A23D7/0056 ,  A23L2/02 ,  A23L33/105 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/17 ,  A23Y2300/21 ,  A61K36/185 ,  A61K36/31 ,  A23V2200/308 ,  A23V2200/3202 ,  A23V2200/3204 ,  A23V2250/21 ,  A23V2250/2131 ,  A23V2200/32 ,  A23V2200/326 ,  A23V2200/324 ,  A23V2200/3262 ,  A23V2200/332 ,  A23V2200/328 ,  A61K2300/00

摘要： The present invention claims the use of pomegranate (Punica granaturn) plant extracts and various combinations of said extracts, some additionally including a probiotic, which allow a synergistic effect between the bioactive components thereof, for the purpose of preparing dietary supplements, functional foods/beverages, food additives and drugs for use in caring for human health.

摘要翻译： 本发明要求使用石榴（Punica granaturn）植物提取物和所述提取物的各种组合，一些另外包括益生菌，其允许其生物活性成分之间的协同作用，用于制备膳食补充剂，功能食品/饮料 ，用于照顾人类健康的食品添加剂和药物。

公开(公告)号：US20110225660A1

公开(公告)日：2011-09-15

申请号：US13123295

申请日：2008-10-10

申请人： Sergio A. Streitenberger ,  Marcos Peñalver Mellado ,  José A. López Más ,  Yolanda Pedreño López ,  Juan P. Sola González ,  Pedro Martínez Ortiz ,  Victoriano Mulero Mendez ,  Francisco Roca Soler ,  Jorge Galindo Villegas

发明人： Sergio A. Streitenberger ,  Marcos Peñalver Mellado ,  José A. López Más ,  Yolanda Pedreño López ,  Juan P. Sola González ,  Pedro Martínez Ortiz ,  Victoriano Mulero Mendez ,  Francisco Roca Soler ,  Jorge Galindo Villegas

IPC分类号： A01K67/00 ,  A61K9/50 ,  A61K39/00 ,  C12N11/08

CPC分类号： A61K9/5026 ,  A23K20/147 ,  A23K40/30 ,  A23K50/80 ,  A61K38/1706 ,  A61K38/191

摘要： An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor α (TNFα) over-expressed in a host microorganism.

摘要翻译： 口服给药的免疫刺激剂产品包含微胶囊化的细胞因子和保护细胞因子的肠溶保护聚合物，细胞因子是鱼，软体动物或甲壳动物细胞因子，优选重组细胞因子如宿主微生物中过表达的肿瘤坏死因子α（TNFα） 。

公开(公告)号：US09155708B2

公开(公告)日：2015-10-13

申请号：US13123295

申请日：2008-10-10

申请人： Sergio A. Streitenberger ,  Marcos Peñalver Mellado ,  José A. López Más ,  Yolanda Pedreño López ,  Juan P. Sola González ,  Pedro Martínez Ortiz ,  Victoriano Mulero Mendez ,  Francisco Roca Soler ,  Jorge Galindo Villegas

发明人： Sergio A. Streitenberger ,  Marcos Peñalver Mellado ,  José A. López Más ,  Yolanda Pedreño López ,  Juan P. Sola González ,  Pedro Martínez Ortiz ,  Victoriano Mulero Mendez ,  Francisco Roca Soler ,  Jorge Galindo Villegas

IPC分类号： A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  C12N1/19 ,  C12N15/12 ,  A61K9/50 ,  A23K1/00 ,  A23K1/16 ,  A23K1/18

CPC分类号： A61K9/5026 ,  A23K20/147 ,  A23K40/30 ,  A23K50/80 ,  A61K38/1706 ,  A61K38/191

摘要： An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor α (TNFα) over-expressed in a host microorganism.

摘要翻译： 口服给药的免疫刺激剂产品包含微胶囊化的细胞因子和保护细胞因子的肠溶保护聚合物，细胞因子是鱼，软体动物或甲壳动物细胞因子，优选重组细胞因子如宿主微生物中过表达的肿瘤坏死因子α（TNFα） 。