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公开(公告)号：US5939431A
公开(公告)日：1999-08-17
申请号：US878860
申请日：1997-06-19
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： Compounds of formula ##STR1## or pharmaceutically acceptable salts thereof, wherein E, Q, T, U, V, L, Z, X, W, M, Y and Y' are as set forth herein, are described. These compounds are useful as agents in the treatment of allergy, inflammation, autoimmune diseases, B-cell lymphomas, tumors, and the after effects of bone marrow transplantation.
摘要翻译： 其中E，Q，T，U，V，L，Z，X，W，M，Y和Y'的式或其药学上可接受的盐的化合物如本文所述。 这些化合物可用作治疗过敏，炎症，自身免疫性疾病，B细胞淋巴瘤，肿瘤和骨髓移植的后期作用的药剂。
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公开(公告)号：US07960433B2
公开(公告)日：2011-06-14
申请号：US11705929
申请日：2007-02-14
申请人： Arthur G. Taveras , Motasim Billah , Daniel Lundell , William Kreutner , James Jakway , Jay S. Fine , Loretta A. Bober , Jianhua Chao , Purakkattle J. Biju , Younong Yu
发明人： Arthur G. Taveras , Motasim Billah , Daniel Lundell , William Kreutner , James Jakway , Jay S. Fine , Loretta A. Bober , Jianhua Chao , Purakkattle J. Biju , Younong Yu
IPC分类号： A01N43/08 , A01N43/02 , A61K31/34 , A61K31/335
CPC分类号： A61K45/06
摘要： Methods of treating chemokine-mediated diseases are disclosed. The methods comprise the administration of CXC-Chemokine receptor antagonists of the formula or pharmaceutically acceptable salts or solvates thereof, in combination with other classes of pharmaceutical compounds. The chemokine-mediated diseases include acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, asthma and cancer. Also disclosed are novel compounds of formula (I).
摘要翻译： 公开了治疗趋化因子介导的疾病的方法。 所述方法包括与其它类别的药物化合物组合施用下式的CXC趋化因子受体拮抗剂或其药学上可接受的盐或溶剂合物。 趋化因子介导的疾病包括急性和慢性炎性疾病，牛皮癣，囊性纤维化，哮喘和癌症。 还公开了式（I）的新化合物。
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3.发明授权Method for enhancing the antibody response to specific antigens with Interleukin-10 失效用白介素-10增强对特异性抗原的抗体应答的方法
公开(公告)号：US5866134A
公开(公告)日：1999-02-02
申请号：US410199
申请日：1995-03-24
申请人： Jay S. Fine , Michael J. Grace
发明人： Jay S. Fine , Michael J. Grace
CPC分类号： A61K39/39 , A61K39/092 , A61K2039/55527
摘要： A method for enhancing the immune response of a mammal to a vaccine comprising administering to such a mammal an effective amount of IL-10 in conjunction with the vaccine. A pharmaceutical composition comprised of an effective amount of IL-10, a natural, synthetic or recombinant antigen and a pharmaceutcally acceptable carrier.
摘要翻译： 一种用于增强哺乳动物对疫苗的免疫应答的方法，包括向所述哺乳动物施用有效量的IL-10与疫苗结合。 由有效量的IL-10，天然的，合成的或重组抗原和药物可接受的载体组成的药物组合物。
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公开(公告)号：US07560449B2
公开(公告)日：2009-07-14
申请号：US10701244
申请日：2003-11-04
申请人： Jay S. Fine , Eric McFee Parker
发明人： Jay S. Fine , Eric McFee Parker
IPC分类号： A61K31/33
CPC分类号： A61K45/06 , A61K31/366 , A61K31/397 , A61K31/40 , A61K2300/00
摘要： The present invention provides methods for treating demyelination and associated conditions by administering at least one sterol absorption inhibitor and compositions, therapeutic combinations and methods including: (a) at least one sterol absorption inhibitor; and (b) at least one demyelination treatment which can be useful for preventing or treating demyelination and associated conditions, such as multiple sclerosis.
摘要翻译： 本发明提供了通过施用至少一种甾醇吸收抑制剂和组合物，治疗组合和方法来治疗脱髓鞘和相关病症的方法，包括：（a）至少一种甾醇吸收抑制剂; 和（b）可用于预防或治疗脱髓鞘和相关病症如多发性硬化的至少一种脱髓鞘治疗。
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5.发明申请3,4-Di-Substituted Cyclobutene-1,2-Diones as CXC-Chemokine Receptor Ligands 审中-公开3,4-二取代的环丁烯-1,2-二酮作为CXC趋化因子受体配体公开(公告)号：US20110213029A1
公开(公告)日：2011-09-01
申请号：US13102554
申请日：2011-05-06
申请人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号： A61K31/341 , A61P11/00
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译： 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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6.发明申请3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS 有权作为CXC-CHEMOKINE受体配体的3,4-二取代的环己基-1,2-二酮公开(公告)号：US20090306079A1
公开(公告)日：2009-12-10
申请号：US12352781
申请日：2009-01-13
申请人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号： A61K31/535 , C07D401/04 , C07D295/14 , A61P37/02 , A61P9/12 , A61K31/497
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译： 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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7.发明申请公开(公告)号：US20080166318A1
公开(公告)日：2008-07-10
申请号：US12042640
申请日：2008-03-05
申请人： Jay S. Fine , Eric McFee Parker
发明人： Jay S. Fine , Eric McFee Parker
IPC分类号： A61K31/397 , A61K38/21 , A61P25/00
CPC分类号： A61K45/06 , A61K31/366 , A61K31/397 , A61K31/40 , A61K2300/00
摘要： The present invention provides methods for treating demyelination and associated conditions by administering at least one sterol absorption inhibitor and compositions, therapeutic combinations and methods including: (a) at least one sterol absorption inhibitor; and (b) at least one demyelination treatment which can be useful for preventing or treating demyelination and associated conditions, such as multiple sclerosis.
摘要翻译： 本发明提供了通过施用至少一种甾醇吸收抑制剂和组合物，治疗组合和方法来治疗脱髓鞘和相关病症的方法，包括：（a）至少一种甾醇吸收抑制剂; 和（b）可用于预防或治疗脱髓鞘和相关病症如多发性硬化的至少一种脱髓鞘治疗。
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8.发明授权3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号：US07132445B2
公开(公告)日：2006-11-07
申请号：US10630258
申请日：2003-07-30
申请人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , James P. Jakway , Gaifa Lai , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , James P. Jakway , Gaifa Lai , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号： A61K31/341 , A61K31/343 , A61K31/381 , C07D333/10 , C07D33/72
CPC分类号： C07D207/335 , C07C225/20 , C07C237/30 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译： 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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