摘要:
Target cell specificity of delivery vectors is provided by incorporation of a target cell specific binding domain by the use of any binding domain, which binds specifically to a binding site on the target cell. The binding site may be endogenous to the target cell, provided by engineering the target cell, or a suitable binding site may be associated with the target cell. Target cells may also be associated with a CVR polypeptide to provide specificity for the delivery vector. The association of the CVR polypeptide confers target cell specificity for a second virus host cell range, which specificity differs from the viral host cell range of the endogenous target cell or animal host cell viral receptors. The CVR polypeptide may thus comprise a chimeric virus binding site which binds a second virus env binding domain specific for a second virus host cell range, selected from at least one of the group consisting of amphotropic, polytropic, xenotropic, ecotropic and tissue specific.
摘要:
Target cell specificity of delivery vectors is provided by incorporation of a target cell specific binding domain by the use of any binding domain, which binds specifically to a binding site on the target cell. The binding site may be endogenous to the target cell, provided by engineering the target cell, or a suitable binding site may be associated with the target cell. Target cell may also be associated with a CVR polypeptide to provide specificity for the delivery vector. The association of the CVR polypeptide confers target cell specificity for a second virus host cell range, which specificity differs from the viral host cell range of the endogeneous target cell or animal host cell viral receptors. The CVR polypeptide may thus comprise a chimeric virus binding site which binds a second virus env binding domain specific for a second virus host cell range, selected from at least one of the group consisting of amphotropic, polytropic, xenotropic, ecotropic and tissue specific.
摘要:
In a choke coil adapted to be surface-mounted on a board, a drum core including a core rod, and a circular first flange provided on a lower end of the core rod. A coil is wound around the core rod. Each of a pair of electrodes is electrically connected to an associated one end of the coil, and includes a first part provided on a lower face of the first flange adapted to oppose a connection land on the board and a second part provided on a side face of the first flange. The second part of each of the electrodes is adapted to hold a solder fillet together with the land. In a case where a hypothetic square circumscribing an outer periphery of the first flange is defined, the second part is located within the square and on a line connecting diagonal corners of the square.
摘要:
In a choke coil adapted to be surface-mounted on a board, a drum core including a core rod, and a circular first flange provided on a lower end of the core rod. A coil is wound around the core rod. Each of a pair of electrodes is electrically connected to an associated one end of the coil, and includes a first part provided on a lower face of the first flange adapted to oppose a connection land on the board and a second part provided on a side face of the first flange. The second part of each of the electrodes is adapted to hold a solder fillet together with the land. In a case where a hypothetic square circumscribing an outer periphery of the first flange is defined, the second part is located within the square and on a line connecting diagonal corners of the square.